Polymeric DNA hydrogel: Design, synthesis and applications

Feng, Li; Tang, Jianpu; Geng, Jinhui; Luo, Dan; Yang, Dayong

doi:10.1016/j.progpolymsci.2019.101163

Cited by 228 publications

(136 citation statements)

References 135 publications

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“…The reaction extended the length of the DNA crosslinking chain in the hydrogel and increased the degree of swelling of the gel (a 100-fold volumetric hydrogel expansion was achieved by the successive extension of the crosslinks). We strongly recommend a recent review from Yang et al, [238] in which they highlighted the recent progress on DNA hydrogels from a polymeric perspective, including general design principles, synthesis strategies, and applications.…”

Section: Molecular Specific Bindingmentioning

confidence: 99%

Hydrogel: Diversity of Structures and Applications in Food Science

Jia

Luo

2021

Food Reviews International

115

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Hydrogels are a series of soft and wet materials with three dimensions of crosslinked networks. Hydrogels have attracted great attention due to their diverse functional properties, and their wide range of applications, such as in soft robots and actuators, stretched electronic devices, tissue engineering materials, controlled-release drug delivery vehicles, biomedicine materials, food science, and (bio)sensors. In general, there are four core concerns in hydrogel science, including the polymer source, structure fabrication, gel function, and gel applications. According to the logic that the "structure determines function", it is believed that rational design of structures can effectively regulate the functions and applications of hydrogels. Hence, in the current review, "structure" as the core topic will be highly regarded, and the crosslinking mechanisms and structural diversity of hydrogels are comprehensively summarized. Additionally, hydrogels also show their great application potential in food science. Hence, the current review also pays more attention to the application of hydrogels in food nutrition and health, food engineering and processing, and food safety. It is whished that this review not only serves as a reference for improving the comprehensive understanding of the structural design of hydrogels but also provides a forward-looking idea for hydrogel applications in food science.

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Section: Molecular Specific Bindingmentioning

confidence: 99%

Hydrogel: Diversity of Structures and Applications in Food Science

Jia

Luo

2021

Food Reviews International

115

View full text Add to dashboard Cite

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“…Polymeric hydrogels generally demonstrate robust mechanical strength because of their dense, entangled, and crosslinked networks with small mesh sizes. Unlike these conventional hydrogels, pure DNA hydrogels are more thixotropic and can display poor mechanical strength [46]. Although the mechanical properties of DNA hydrogels can be fine-tuned by adjusting the type and concentration of initial DNA tiles with different numbers of branches, even the toughest DNA hydrogel only exhibits a storage modulus of a few thousand Pa [46].…”

Section: Rheological Properties Of Dna Hydrogelsmentioning

confidence: 99%

“…Unlike these conventional hydrogels, pure DNA hydrogels are more thixotropic and can display poor mechanical strength [46]. Although the mechanical properties of DNA hydrogels can be fine-tuned by adjusting the type and concentration of initial DNA tiles with different numbers of branches, even the toughest DNA hydrogel only exhibits a storage modulus of a few thousand Pa [46]. Because of this property, the applications of DNA hydrogels are limited to only certain fields.…”

Section: Rheological Properties Of Dna Hydrogelsmentioning

confidence: 99%

Mechanical and Electrical Properties of DNA Hydrogel-Based Composites Containing Self-Assembled Three-Dimensional Nanocircuits

et al. 2021

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Molecular self-assembly of DNA has been developed as an effective construction strategy for building complex materials. Among them, DNA hydrogels are known for their simple fabrication process and their tunable properties. In this study, we have engineered, built, and characterized a variety of pure DNA hydrogels using DNA tile-based crosslinkers and different sizes of linear DNA spacers, as well as DNA hydrogel/nanomaterial composites using DNA/nanomaterial conjugates with carbon nanotubes and gold nanoparticles as crosslinkers. We demonstrate the ability of this system to self-assemble into three-dimensional percolating networks when carbon nanotubes and gold nanoparticles are incorporated into the DNA hydrogel. These hydrogel composites showed interesting non-linear electrical properties. We also demonstrate the tuning of rheological properties of hydrogel-based composites using different types of crosslinkers and spacers. The viscoelasticity of DNA hydrogels is shown to dramatically increase by the use of a combination of interlocking DNA tiles and DNA/carbon nanotube crosslinkers. Finally, we present measurements and discuss electrically conductive nanomaterials for applications in nanoelectronics.

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“…By attaching DNA to polymers as the side chain, DNAs function as non-covalent cross-linkers in the hydrogel network and support the self-assembling of the synthetic networks into second-order or higher-ordered structures in suitable environments, leading to form multifunctional materials based on DNAs and non-natural polymers [ 171 , 212 , 213 ]. DNA-hydrogel assemblies can be formed with high mechanical strength, biocompatibility and controllable morphologies while their functions, such as sequence designability, recognition ability, responsiveness, and programmability can be easily adjusted by the choice of DNA and hydrogel [ 214 ]. DNA-linked hydrogels are a great alternative, to classically cross-linked gels for cell scaffolding [ 31 , 215 ].…”

Section: Biomolecules For Tissue Regenerationmentioning

confidence: 99%

Design of Bio-Conjugated Hydrogels for Regenerative Medicine Applications: From Polymer Scaffold to Biomolecule Choice

et al. 2020

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Bio-conjugated hydrogels merge the functionality of a synthetic network with the activity of a biomolecule, becoming thus an interesting class of materials for a variety of biomedical applications. This combination allows the fine tuning of their functionality and activity, whilst retaining biocompatibility, responsivity and displaying tunable chemical and mechanical properties. A complex scenario of molecular factors and conditions have to be taken into account to ensure the correct functionality of the bio-hydrogel as a scaffold or a delivery system, including the polymer backbone and biomolecule choice, polymerization conditions, architecture and biocompatibility. In this review, we present these key factors and conditions that have to match together to ensure the correct functionality of the bio-conjugated hydrogel. We then present recent examples of bio-conjugated hydrogel systems paving the way for regenerative medicine applications.

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Polymeric DNA hydrogel: Design, synthesis and applications

Cited by 228 publications

References 135 publications

Hydrogel: Diversity of Structures and Applications in Food Science

Hydrogel: Diversity of Structures and Applications in Food Science

Mechanical and Electrical Properties of DNA Hydrogel-Based Composites Containing Self-Assembled Three-Dimensional Nanocircuits

Design of Bio-Conjugated Hydrogels for Regenerative Medicine Applications: From Polymer Scaffold to Biomolecule Choice

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