Polymeric hollow fiber membrane oxygenators as artificial lungs: A review

Teber, Oğuz Orhun; Altınay, Ayşegül Derya; Mehrabani, Seyed Ali Naziri; Taşdemir, Reyhan Şengür; Zeytuncu, Bihter; Ates‐Genceli, Esra; Dülekgürgen, Ebru; Pekkan, Kerem; Koyuncu, İsmail

doi:10.1016/j.bej.2022.108340

Cited by 40 publications

(17 citation statements)

References 97 publications

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Section: Biomedical Applications Of Membranesmentioning

confidence: 99%

“…Hollow fiber membranes have been used as an oxygenator and are usually obtained via a phase inversion process [ 191 , 192 ]. The commonly used polymers for hollow fiber membranes are hydrophobic polymers, such as polymethylpentene (PMP), polypropylene (PP), PDMS, polysulfone (PSf), polyethersulfone (PES), polyethylene (PE) and polyvinylidene fluoride (PVDF) [ 26 , 192 , 193 , 194 , 195 , 196 , 197 , 198 ]. Wang et al [ 194 ] reported the production of poly (4-methyl-1-pentene)/polypropylene (PMP/PP) thin film composite (TFC) with a PVA/PSS coating was anchored on the membrane surface via crosslinking and PDA binding for membrane oxygenator application.…”

Section: Biomedical Applications Of Membranesmentioning

confidence: 99%

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Polymeric Membranes for Biomedical Applications

2023

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Polymeric membranes are selective materials used in a wide range of applications that require separation processes, from water filtration and purification to industrial separations. Because of these materials’ remarkable properties, namely, selectivity, membranes are also used in a wide range of biomedical applications that require separations. Considering the fact that most organs (apart from the heart and brain) have separation processes associated with the physiological function (kidneys, lungs, intestines, stomach, etc.), technological solutions have been developed to replace the function of these organs with the help of polymer membranes. This review presents the main biomedical applications of polymer membranes, such as hemodialysis (for chronic kidney disease), membrane-based artificial oxygenators (for artificial lung), artificial liver, artificial pancreas, and membranes for osseointegration and drug delivery systems based on membranes.

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Section: Biomedical Applications Of Membranesmentioning

confidence: 99%

Section: Biomedical Applications Of Membranesmentioning

confidence: 99%

Polymeric Membranes for Biomedical Applications

2023

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“…In an ECMO system, the blood is drawn with a roller pump from the vena cavae, oxygenated, and returned to the aorta via venous and aortic cannulae. 2 The importance of ECMO is evident, as it can be used in cases of cardiac failure and severe respiratory dysfunction. 3 The emerging critical role of ECMO in supporting H1N1, MERS, and COVID-19 patients is evident.…”

Section: Introductionmentioning

confidence: 99%

“…3 The emerging critical role of ECMO in supporting H1N1, MERS, and COVID-19 patients is evident. 2,4,5 IVOX is the other device configuration, particularly for patients with acute respiratory distress syndrome. IVOX is defined as compact devices that provide gas exchange and consist of a membrane package inserted in the vena cava again with the hollow fibers.…”

Section: Introductionmentioning

confidence: 99%

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Characterization and comparative evaluation of polysulfone and polypropylene hollow fiber membranes for blood oxygenators

Teber,

Altinay,

Naziri Mehrabani

et al. 2024

J of Applied Polymer Sci

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Blood oxygenators are used to saturate oxygen levels and remove carbon dioxide from the body during cardiopulmonary bypass. Although the natural lung is hydrophilic, commercially used oxygenator materials are hydrophobic. Surface hydrophobicity weakens blood compatibility, as long‐term contact with the blood environment may lead to different degrees of blood activity. Polysulfone may be considered an alternative hydrophilic material in the design of oxygenators. Therefore, it may be directed toward developing hydrophilic membranes. This study aims to investigate the feasibility of achieving blood gas transfer with a polysulfone‐based microporous hollow fiber membrane and compare it with the commercially available polypropylene membranes. Structural differences in the membrane morphology, surface hydrophilicity, tortuosity, mass transfer rate, and material properties under different operation conditions of temperature and flow rates are reported. The polysulfone membrane has a water contact angle of 81.3°, whereas a commercial polypropylene membrane is 94.5°. The mass transfer resistances (s/m) for the polysulfone and polypropylene membranes are calculated to be 4.8 × 104 and 1.5 × 104 at 25°C, respectively. The module made of polysulfone was placed in the cardiopulmonary bypass circuit in parallel with the commercial oxygenator, and pH, pO2, pCO2 levels, and metabolic activity were measured in blood samples.

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Asymmetric Triple‐Functional Janus Membrane for Blood Oxygenation

Zhao,

Gao,

Chang

et al. 2023

Adv Healthcare Materials

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The oxygenation membrane, a core material of extracorporeal membrane oxygenation (ECMO), is facing challenges in balancing anti‐plasma leakage, gas exchange efficiency, and hemocompatibility. Here, inspired by the asymmetric structural features of alveolus pulmonalis, a novel triple‐functional membrane for blood oxygenation with a Janus architecture is proposed, which is composed of a hydrophobic polydimethylsiloxane (PDMS) layer to prevent plasma leakage, an ultrathin polyamide layer to enhance gas exchange efficiency with a CO2:O2 permeance ratio of ≈10.7, and a hydrophilic polyzwitterionic layer to improve the hemocompatibility. During the simulated ECMO process, the Janus oxygenation membrane exhibits excellent performance in terms of thrombus formation and plasma leakage prevention, as well as adequate O2 transfer rate (17.8 mL min−1 m−2) and CO2 transfer rate (70.1 mL min−1 m−2), in comparison to the reported oxygenation membranes. This work presents novel concepts for the advancement of oxygenation membranes and demonstrates the application potential of the asymmetric triple‐functional Janus oxygenation membrane in ECMO.

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Polymeric hollow fiber membrane oxygenators as artificial lungs: A review

Cited by 40 publications

References 97 publications

Polymeric Membranes for Biomedical Applications

Polymeric Membranes for Biomedical Applications

Characterization and comparative evaluation of polysulfone and polypropylene hollow fiber membranes for blood oxygenators

Asymmetric Triple‐Functional Janus Membrane for Blood Oxygenation

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