Polymeric Materials: Current Status of Biocompatibility

Bruck, Stephen D.

doi:10.3109/10731197309118864

Cited by 52 publications

(16 citation statements)

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“…28 Polyester is more resilient and handles more readily, carbon fibres are more likely to become infiltrated by and incorporated into fibrous tissue. 29 This paper reviews our early experience with this material in the subcutaneous tissue of the eyelid as a frontalis sling. All patients had a minimal follow-up period of three months.…”

Section: Discussionmentioning

confidence: 99%

A new synthetic material for the brow suspension procedure.

Cole

O’Connor

Raafai

et al. 1989

British Journal of Ophthalmology

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SUMMARY This report describes the use of a new synthetic material, combining polyester with carbon, in nine brow suspension procedures. The mechanical properties of polyester, with the fibrous tissue inducing properties of carbon, combine to produce a scaffolding on which fibrovascular ingrowth is possible. Subsequent fibrosis gives a permanent effect. Early results indicate that the material is tolerated well in the eyelid, but the problem of early slippage remains.

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Section: Discussionmentioning

confidence: 99%

A new synthetic material for the brow suspension procedure.

Cole

O’Connor

Raafai

et al. 1989

British Journal of Ophthalmology

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“…Recent results shown in Tables 2 and 3, respectively, indicate that grafted polyacrylamide elicits no platelet adhesion and adsorbs the least plasma proteins, especially fibrinogen, gammaglobulin, and albumin. 35 It is interesting that in the case of poly(2-hydroxyethylmethacrylate) the equilibrium water Table 2. Platelet adhesion from heparinised whole canine blood to polyacrylamide hydrogel covalently grafted onto polyurethane in rotating disc experiments at 400 rpm after 3 mm (data from uptake is limited to approximately 30-35% owing to phase separation and can be changed by copolymerization with hydrophilic monomers.…”

Section: Interactions Of Blood Components With Surfacesmentioning

confidence: 99%

Polymeric Materials in the Physiological Environment

Bruck¹

1976

Pure and Applied Chemistry

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Abstract-The interactions between natural and synthetic materials and blood components are analyzed with emphasis on the interdependence between biomaterials research and development and ultimate applications. Two new synthetic polymers, perfluorobutyryl ethylcellulose and polyalkylsulfone, that combine desirable blood compatibility and gas-to-blood transfer rates are discussed in terms of their potential usefulness for membrane oxygenators. Among the several hydrogels, polyacrylamide covalently grafted onto segmented polyether-urethane substrates showed essentially no platelet adhesion and adsorbed the least plasma proteins in comparison to other systems. Polymeric composites having stiffness, anisotropies that approximate living tissues, and the ability to culture cells and hence to maintain a living cellular interface between flowing blood and microfiber substrates, are expected to expand the horizons for biomaterials in prosthetic applications.

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“…In this study, expression (6) has been used because the fractional release of ara-C (F ara-C ) exhibits linear behaviour with the square root of time (t 1/2 ) when F ara-C`0 .6 for the gels studied; an example is given in Fig 2. Thus, the ara-C delivery shows a Fickian diffusion mechanism and the D ara-C values can be obtained from eqn (6). In all cases, total release was achieved, showing that no strong interaction of the drug with the gel components takes place during polymerization.…”

mentioning

confidence: 99%

“…The main polymers used for both biomedical applications and controlled-release systems of many drugs are hydrogels. 6,7 The utility of the hydrogels as biomaterials lies in the similarity of their physical properties to those of a natural tissue in its biological environment. 8 This resemblance is based on their water content, soft and rubbery consistency and low interfacial tension with water or biological¯uids.…”

Section: Introductionmentioning

confidence: 99%