Polymeric materials for ultrasound imaging and therapy

Barmin, Roman A.; Moosavifar, MirJavad; Dasgupta, Anshuman; Herrmann, Andreas; Kiessling, Fabian; Pallares, Roger M.; Lammers, Twan

doi:10.1039/d3sc04339h

Cited by 12 publications

(2 citation statements)

References 98 publications

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“…[ 36,37 ] Although this was a significant improvement compared to 20 kHz US for potential biocompatibility, the inherent reliance on inertial cavitation will prohibit the safe use of this system in living systems. Therefore, further research to activate DNAzymes, e.g., by stable cavitation using auxiliaries like microbubbles [ 38,39 ] will be necessary. Moreover, the reduction of tissue damage through cavitation effects mandates short sonication times.…”

Section: Discussionmentioning

confidence: 99%

Mechanochemical Activation of DNAzyme by Ultrasound

Rath,

Göstl,

Herrmann

2024

Advanced Science

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Controlling the activity of DNAzymes by external triggers is an important task. Here a temporal control over DNAzyme activity through a mechanochemical pathway with the help of ultrasound (US) is demonstrated. The deactivation of the DNAzyme is achieved by hybridization to a complementary strand generated through rolling circle amplification (RCA), an enzymatic polymerization process. Due to the high molar mass of the resulting polynucleic acids, shear force can be applied on the RCA strand through inertial cavitation induced by US. This exerts mechanical force and leads to the cleavage of the base pairing between RCA strand and DNAzyme, resulting in the recovery of DNAzyme activity. This is the first time that this release mechanism is applied for the activation of catalytic nucleic acids, and it has multiple advantages over other stimuli. US has higher penetration depth into tissues compared to light, and it offers a more specific stimulus than heat, which has also limited use in biological systems due to cell damage caused by hyperthermia. This approach is envisioned to improve the control over DNAzyme activity for the development of reliable and specific sensing applications.

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Section: Discussionmentioning

confidence: 99%

Mechanochemical Activation of DNAzyme by Ultrasound

Rath,

Göstl,

Herrmann

2024

Advanced Science

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“…24,25 Moreover, the MB air-filled core displays acoustic responsiveness, leading to its primary use in US contrast imaging. 26 The PBCA MB platform is biocompatible at diagnostic doses, and can be bioconjugated with targeting agents, expanding its use to molecular imaging and targeted drug delivery, among others. 24,27,28 In a previous study, we demonstrated the good loading of hydrophobic molecules with different chemical structures, namely nile red (log P value of 3.5), coumarin 6 (log P 4.9), and pyrene (log P 6.0) in PBCA MB, and their US-induced release.…”

Section: Introductionmentioning

confidence: 99%

Hybrid ultrasound and photoacoustic contrast agent designs combining metal phthalocyanines and PBCA microbubbles

Barmin,

Moosavifar,

Zhang

et al. 2024

J. Mater. Chem. B

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Polymeric Microbubble Shell Engineering: Microporosity as a Key Factor to Enhance Ultrasound Imaging and Drug Delivery Performance

Moosavifar,

Barmin,

Rama

et al. 2024

Advanced Science

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Microbubbles (MB) are widely used as contrast agents for ultrasound (US) imaging and US‐enhanced drug delivery. Polymeric MB are highly suitable for these applications because of their acoustic responsiveness, high drug loading capability, and ease of surface functionalization. While many studies have focused on using polymeric MB for diagnostic and therapeutic purposes, relatively little attention has thus far been paid to improving their inherent imaging and drug delivery features. This study here shows that manipulating the polymer chemistry of poly(butyl cyanoacrylate) (PBCA) MB via temporarily mixing the monomer with the monomer‐mimetic butyl cyanoacetate (BCC) during the polymerization process improves the drug loading capacity of PBCA MB by more than twofold, and the in vitro and in vivo acoustic responses of PBCA MB by more than tenfold. Computer simulations and physisorption experiments show that BCC manipulates the growth of PBCA polymer chains and creates nanocavities in the MB shell, endowing PBCA MB with greater drug entrapment capability and stronger acoustic properties. Notably, because BCC can be readily and completely removed during MB purification, the resulting formulation does not include any residual reagent beyond the ones already present in current PBCA‐based MB products, facilitating the potential translation of next‐generation PBCA MB.

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Polymeric materials for ultrasound imaging and therapy

Abstract: Ultrasound (US) is routinely used for diagnostic imaging and increasingly employed for therapeutic applications. Materials that act as cavitation nuclei can improve the resolution of US imaging, and facilitate therapeutic...

Cited by 12 publications

References 98 publications

Mechanochemical Activation of DNAzyme by Ultrasound

Mechanochemical Activation of DNAzyme by Ultrasound

Hybrid ultrasound and photoacoustic contrast agent designs combining metal phthalocyanines and PBCA microbubbles

Polymeric Microbubble Shell Engineering: Microporosity as a Key Factor to Enhance Ultrasound Imaging and Drug Delivery Performance

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