Polymeric Membrane Sensors for the Selective Determination of Dextromethorphan in Pharmaceutical Preparations

Abstract

The construction and electrochemical response characteristics of poly(vinyl chloride) matrix ion-selective electrodes (ISEs) for dextromethorphan (DXM) hydrobromide are described. The membranes incorporate ion-association complexes of DXM with reineckate salt {[Cr(NH3)2(SCN)4]NH4} or phosphomolybdic acid [H3(PMo12O40)], as electroactive materials and dioctylphthalate or dibutylsebacate as a plasticizing solvent mediator. The sensors display a fast, stable and linear response with slopes of 54.4 to 59.5 mV/decade at pH 2.5 -6.5 and a detection limit of 1.0 ¥ 10 -6 M. Moreover, the sensors exhibit very good selectivity for DXM over opiate alkaloids, as well as organic and inorganic cations. The sensors proved to be useful for the determination of 5.0 ¥ 10 -5 -1.0 ¥ 10 -3 M DXM hydrobromide in pure as well as in dosage forms by direct potentiometry and standard addition methods. Determination of 5.0 ¥ 10 -4 M DXM using the standard addition method and a sensor based on phosphomolybdate and dioctylphthalate shows an average recovery of 99.8% and a relative standard deviation (RSD) of 0.4%.

Bioelectroanalysis of pharmaceutical compounds

“…These include sensors for dextromethorphan, a highly effective non-opioid antitussive drug (reineckate salt or phosphomolybdate electroactive agents) [280], for oxybutynin hydrochloride and flavoxate hydrochloride urogenital system drugs (reineckate salt or tungstophosphate) [281] or antidiabetic drugs were also determined by carbon paste-based and PVC membrane-based ISEs (reineckate salt or tungstophosphate) [282].…”

Comparison of classic and derivative UV spectrophotometric methods for determination of dextromethorphani hydrobromidum

“…Most of those analytical methods imply chromatographic techniques, such as HLPC (Galli & Barbas, 2004, Lin et al, 2007, Santagati et al, 2005, HPLC-MS/MS (Lou et al, 2010, Zhang et al, 2010, GC-MS (Bagheri et al, 2005), and capillary electrophoresis (Dong et al, 2005, Yang et al, 2008. For the quantification of DXM, literature recommended either electrooxidation on a carbon nanotube--carbon microparticle liquid composite (Heli et al, 2010), or FIA with potentiometric detection (Khaled et al, 2010) and potentiometric membrane sensors (El-Naby, 2008). However, many of these methods require several time-consuming manipulation steps, sophisticated instruments and special training.…”

Molecularly imprinted polymer cartridges coupled on-line with high performance liquid chromatography for simple and rapid analysis of dextromethorphan in human plasma samples

“…Dextromethorphan is also being investigated as a possible treatment for neuropathic pain and pain associated with fibromyalgia [1]. The drug has been quantified using different methods such as LC-MS-MS [2], GC-MS [3], HPLC [4,6], potentiometric sensor [5], spectrophotometry [7], capillary electrophoresis [8], and fluorimetry [9].…”