Polymeric micelles and nanoemulsions as drug carriers: Therapeutic efficacy, toxicity, and drug resistance

Gupta, Roohi; Shea, Jill E.; Scaife, Courtney L.; Shurlygina, A. V.; Rapoport, Natalya

doi:10.1016/j.jconrel.2015.06.019

Cited by 92 publications

(61 citation statements)

References 35 publications

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“…This may be because the relatively long crystalline block of PLLA significantly reduces its solubility in the mixture of THF and PBS. 20 PLLA was therefore removed from subsequent studies.…”

Section: Moving Towards Clinical Applicability and Translationmentioning

confidence: 99%

Polymeric perfluorocarbon nanoemulsions are ultrasound-activated wireless drug infusion catheters

Zhong

Yoon

Aryal

et al. 2018

Preprint

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The holy grail of drug delivery nanotechnology is the ability to target the right drug to the right part of the body at the right time. Here, we demonstrate that polymeric perfluoropentane nanoemulsions are a generalized platform for targeted drug delivery with high potential for clinical translation. We delineate a production protocol optimized for nanoparticle size, monodispersity, drug loading, and stability, and hew to clinical production standards. We confirm that varied drugs may be effectively uncaged with ultrasound using this nanoparticle system, with drug loading increasing with hydrophobicity. Finally, we exhibit the in vivo efficacy of this system in two organ systems: we enable targeted modulation of brain activity with anesthetic uncaging and we locally control cardiovascular function with vasodilator uncaging. This work establishes the power of polymeric perfluoropentane nanoemulsions as a clinically-translatable platform for noninvasive ultrasonic drug uncaging for myriad targets in the brain and body.

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Section: Moving Towards Clinical Applicability and Translationmentioning

confidence: 99%

Polymeric perfluorocarbon nanoemulsions are ultrasound-activated wireless drug infusion catheters

Zhong

Yoon

Aryal

et al. 2018

Preprint

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“…Soft condensed matter has high similarity with characteristics of biological tissues; therefore, these have been exploited to investigate tissue mechanics and have been successful in explaining dynamical tissue behaviors such as surface tension, elasticity and viscosity [1]. Micelles have been identified to have representative complexity of soft matter systems [2] and have attracted much attention in areas such as nanocarriers for drug delivery [3][4][5][6][7][8][9], mechanical responses [10][11][12][13][14], and cancer treatment [15,16] due to the versatility of the rheological properties with small amphiphilic molecules and their spontaneous selfassembly in a simplicity of the design with surfactant, salt and water [10,[17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Acoustic radiation force optical coherence elastography for evaluating mechanical properties of soft condensed matters and its biological applications

Liu

Kijanka

Urban

2020

Journal of Biophotonics

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Evaluating mechanical properties of biological soft tissues and viscous mucus is challenging because of complicated dynamic behaviors. Soft condensed matter models have been successfully used to explain a number of dynamical behaviors. Here, we reported that optical coherence elastography (OCE) is capable of quantifying mechanical properties of soft condensed matters, micellar fluids. A 7.5 MHz focused transducer was utilized to generate acoustic radiation force exerted on the surface of soft condensed matters in order to produce Rayleigh waves. The waves were recorded by optical coherence tomography (OCT). The Kelvin‐Voigt model was adopted to evaluate shear modulus and loss modulus of soft condensed matters. The results reported that various concentrations of micellar fluids can provide reasonable ranges of elasticity from 65.71 to 428.78 Pa and viscosity from 0.035 to 0.283 Pa·s, which are close to ranges for actual biological samples, like mucus. OCE might be a promising tool to differentiate pathologic mucus samples from healthy cases as advanced applications in the future.

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“…Nanomedicine actively target locations by the use of various NFs 14 as a DDS which include nanoparticles, 8 polymeric micelles, 15, 16 nanorods, 17, 18 nanospheres, 19, 20 solid lipid nanoparticles, 21, 22 nanolipososmes, 23, 24 dendrimers, 25, 26 metal nanoparticles 27, 28 , fullerenes and quantum dots. 29, 30 These NFs have been useful in the development of the various different routes like systemic, oral, pulmonary, transdermal and have been helpful for the drug targeting and On-demand drug delivery techniques.…”

Section: Introductionmentioning

confidence: 99%

Recent trends on hydrogel based drug delivery systems for infectious diseases

et al. 2016

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For centuries, the rapid spread and cure of infectious diseases have been a major concern to the progress and survival of humans. These diseases are the global burden and the prominent cause for the worldwide deaths and disability. Nanomedicine has emerged as the most excellent tool to eradicate and halt their spread. Various nanoformulations (NFs) using advanced nanotechnology are in demand. Recently, hydrogel and nanogel based drug delivery devices poses new prospects to simulate the natural intelligence of various biological systems. Owing to their unique porous interpenetrating network design, hydrophobic drug incorporation and stimulus sensitivity hydrogels owe excellent potential as targeted drug delivery system. Present review is an attempt to highlight the recent trends of hydrogel based drug delivery systems for the delivery of therapeutic agents and diagnostics for the major infectious diseases including Acquired immune deficiency syndrome (AIDS), Malaria, Tuberculosis, Influenza and Ebola. Future prospective and challenges are also briefed.

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Polymeric micelles and nanoemulsions as drug carriers: Therapeutic efficacy, toxicity, and drug resistance

Cited by 92 publications

References 35 publications

Polymeric perfluorocarbon nanoemulsions are ultrasound-activated wireless drug infusion catheters

Polymeric perfluorocarbon nanoemulsions are ultrasound-activated wireless drug infusion catheters

Acoustic radiation force optical coherence elastography for evaluating mechanical properties of soft condensed matters and its biological applications

Recent trends on hydrogel based drug delivery systems for infectious diseases

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