Polymeric Micelles and Nanoparticles from Block and Statistical Poly((RS)‐3,3‐dimethylmalic acid) Derivatives: Preparation and Characterization

Abstract

Amphiphilic and biodegradable micelles and nanoparticles designed as potential drug carriers were prepared from biodegradable statistical and block copolyesters obtained by a living anionic ring-opening process. These novel materials display amphiphilic properties arising from the joint presence of hydrophilic poly((RS)-3,3-dimethylmalic acid) and hydrophobic poly(hexyl (RS)-3,3-dimethylmalate) segments. Micelles obtained from a well-defined block copolymer have been characterized by their critical aggregation concentration, and nanoparticles derived from statistical copolymer have been analyzed by transmission electron microscopy (TEM).

Solubilization of Water-Insoluble Drugs Due to Random Amphiphilic and Degradable Poly(dimethylmalic acid) Derivatives

“…Random copolymers were synthesized by ring-opening polymerization of the benzylated lactone and either the hexylated or the decylated lactone with tetraethylammonium benzoate as the initiator, followed by catalytic hydrogenolysis of the benzyl groups with palladium (20 wt %) . Molecular characteristics of the polymers are listed in Table .…”