Polymeric Micelles Based on Modified Glycol Chitosan for Paclitaxel Delivery: Preparation, Characterization and Evaluation

Liang, Na; Sun, Song Yung; Gong, Xianfeng; Li, Qiang; Yan, Pengfei; Cui, Fude

doi:10.3390/ijms19061550

Cited by 29 publications

(12 citation statements)

References 37 publications

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“…Many attempts have been made to find less toxic and better-tolerated carriers to increase the solubility of PTX for intravenous delivery, such as nanoparticles, dendrimers, liposomes and nanosuspensions [ 2 , 3 , 4 , 5 ]. In recent years, polymeric micelles have attracted growing interest due to their attractive characteristics, such as their excellent solubilization ability, small size, high stability, prolonged circulation time, low toxicity, ability to evade scavenging by the mononuclear phagocyte system (MPS), high biocompatibility and efficient accumulation in tumor tissues via an enhanced permeability and retention (EPR) effect [ 6 , 7 ]. The micelles have a unique core–shell structure with hydrophobic segments as the internal core and hydrophilic segments as the outer shell.…”

Section: Introductionmentioning

confidence: 99%

Amphiphilic Polymeric Micelles Based on Deoxycholic Acid and Folic Acid Modified Chitosan for the Delivery of Paclitaxel

Liang

Wang

et al. 2018

IJMS

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The present investigation aimed to develop a tumor-targeting drug delivery system for paclitaxel (PTX). The hydrophobic deoxycholic acid (DA) and active targeting ligand folic acid (FA) were used to modify water-soluble chitosan (CS). As an amphiphilic polymer, the conjugate FA-CS-DA was synthesized and characterized by Proton nuclear magnetic resonance (1H-NMR) and Fourier-transform infrared spectroscopy (FTIR) analysis. The degree of substitutions of DA and FA were calculated as 15.8% and 8.0%, respectively. In aqueous medium, the conjugate could self-assemble into micelles with the critical micelle concentration of 6.6 × 10−3 mg/mL. Under a transmission electron microscope (TEM), the PTX-loaded micelles exhibited a spherical shape. The particle size determined by dynamic light scattering was 126 nm, and the zeta potential was +19.3 mV. The drug loading efficiency and entrapment efficiency were 9.1% and 81.2%, respectively. X-Ray Diffraction (XRD) analysis showed that the PTX was encapsulated in the micelles in a molecular or amorphous state. In vitro and in vivo antitumor evaluations demonstrated the excellent antitumor activity of PTX-loaded micelles. It was suggested that FA-CS-DA was a safe and effective carrier for the intravenous delivery of paclitaxel.

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Section: Introductionmentioning

confidence: 99%

Amphiphilic Polymeric Micelles Based on Deoxycholic Acid and Folic Acid Modified Chitosan for the Delivery of Paclitaxel

Liang

Wang

et al. 2018

IJMS

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“…PTX was also loaded in micelles prepared, by dialysis, from similar FA–cholesterol–CS biopolymer [ 50 ]. The same drug, PTX, was used for the preparation of drug-loaded micelles based on an amphiphilic CS-graft-α-tocophenol succinate copolymer [ 51 ]. Spherical drug-loaded micelles were obtained by an ultrasonication method, and the loading process increased the average micellar diameter from 35 to 142 nm.…”

Section: Micellar Drug Delivery Systems Based On Polysaccharidesmentioning

confidence: 99%

Micellar Drug Delivery Systems Based on Natural Biopolymers

Atanase

2021

Polymers

165

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The broad diversity of structures and the presence of numerous functional groups available for chemical modifications represent an enormous advantage for the development of safe, non-toxic, and cost-effective micellar drug delivery systems (DDS) based on natural biopolymers, such as polysaccharides, proteins, and peptides. Different drug-loading methods are used for the preparation of these micellar systems, but it appeared that dialysis is generally recommended, as it avoids the formation of large micellar aggregates. Moreover, the preparation method has an important influence on micellar size, morphology, and drug loading efficiency. The small size allows the passive accumulation of these micellar systems via the permeability and retention effect. Natural biopolymer-based micellar DDS are high-value biomaterials characterized by good compatibility, biodegradability, long blood circulation time, non-toxicity, non-immunogenicity, and high drug loading, and they are biodegraded to non-toxic products that are easily assimilated by the human body. Even if some recent studies reported better antitumoral effects for the micellar DDS based on polysaccharides than for commercial formulations, their clinical use is not yet generalized. This review is focused on the studies from the last decade concerning the preparation as well as the colloidal and biological characterization of micellar DDS based on natural biopolymers.

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“…These synergic therapy methods have achieved efficient antitumor activity through the phototoxicity of PTT or PDT. In addition, chemotherapy based on stimuli-responsive drug delivery systems (SDDSs) have been implemented in extensive research and have been combined with phototherapy [7,8,9,10,11]. Various sensitive functional groups (e.g., disulfide, hydrazide, and imidazole) have been widely introduced into SDDSs to achieve controllable drug release and cancer therapy [12,13,14,15,16].…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Micelles for NIR/GSH-Triggered Chemophototherapy of Cancer

et al. 2019

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The chemotherapy of stimuli-responsive drug delivery systems (SDDSs) is a promising method to enhance cancer treatment effects. However, the low efficiency of chemotherapy drugs and poor degradation partly limit the application of SDDSs. Herein, we report doxorubicin (DOX)-loading mixed micelles for biotin-targeting drug delivery and enhanced photothermal/photodynamic therapy (PTT/PDT). Glutathione (GSH)-responsive mixed micelles were prepared by a dialysis method, proportionally mixing polycaprolactone-disulfide bond-biodegradable photoluminescent polymer (PCL-SS-BPLP) and biotin-polyethylene glycol-cypate (biotin-PEG-cypate). Chemically linking cypate into the mixed micelles greatly improved cypate solubility and PTT/PDT effect. The micelles also exhibited good monodispersity and stability in cell medium (~119.7 nm), low critical micelles concentration, good biodegradation, and photodecomposition. The high concentration of GSH in cancer cells and near-infrared light (NIR)-mediated cypate decomposition were able to achieve DOX centralized release. Meanwhile, the DOX-based chemotherapy combined with cypate-based NIR-triggered hyperthermia and reactive oxygen species could synergistically induce HepG2 cell death and apoptosis. The in vivo experiments confirmed that the micelles generated hyperthermia and achieved a desirable therapeutic effect. Therefore, the designed biodegradable micelles are promising safe nanovehicles for antitumor drug delivery and chemo/PTT/PDT combination therapy.

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Polymeric Micelles Based on Modified Glycol Chitosan for Paclitaxel Delivery: Preparation, Characterization and Evaluation

Cited by 29 publications

References 37 publications

Amphiphilic Polymeric Micelles Based on Deoxycholic Acid and Folic Acid Modified Chitosan for the Delivery of Paclitaxel

Amphiphilic Polymeric Micelles Based on Deoxycholic Acid and Folic Acid Modified Chitosan for the Delivery of Paclitaxel

Micellar Drug Delivery Systems Based on Natural Biopolymers

Biodegradable Micelles for NIR/GSH-Triggered Chemophototherapy of Cancer

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