Polymeric micelles for acyclovir drug delivery

Sawdon, Alicia J.; Peng, Ching An

doi:10.1016/j.colsurfb.2014.08.011

Cited by 34 publications

(18 citation statements)

References 40 publications

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“…In contrast to the power-law model, the Michaelis-Menten model fits the release of GCV from polymeric micelles well because GCV release is driven by a reaction-diffusion mechanism. According to the Michaelis-Menten model, we found that the dissociation constant (K d ) was equal to 2.79 which is much higher than the release of ACV from ACV-PCL-chitosan polymeric micelles reported previously [ 25 ]. Such extended release of GCV from polymeric micelles probably is due to the relatively robust binding force between GCV-PCL generated by two hydroxyl groups existing on GCV, in comparison with only one hydroxyl moiety on ACV.…”

Section: Resultscontrasting

confidence: 51%

Ring-Opening Polymerization of ε-Caprolactone Initiated by Ganciclovir (GCV) for the Preparation of GCV-Tagged Polymeric Micelles

Sawdon

Peng

2015

Molecules

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Ganciclovir (GCV) is a nucleoside analogue with antiviral activity against herpes viral infections, and the most widely used antiviral to treat cytomegalovirus infections. However, the low bioavailability and short half-life of GCV necessitate the development of a carrier for sustained delivery. In this study, guanosine-based GCV was used as the initiator directly in ring-opening polymerization of ε-caprolactone (ε-CL) to form hydrophobic GCV-poly(caprolactone) (GCV-PCL) which was then grafted with hydrophilic chitosan to form amphiphilic copolymers for the preparation of stable micellar nanoparticles. Successful synthesis of GCV-PCL and GCV-PCL-chitosan were verified by 1H-NMR analysis. Self-assembled micellar nanoparticles were characterized by dynamic light scattering and zetasizer with an average size of 117 nm and a positive charge of 24.2 mV. The drug release kinetics of GCV was investigated and cytotoxicity assay demonstrated that GCV-tagged polymeric micelles were non-toxic. Our results showed that GCV could be used directly in the initiation of ring-opening polymerization of ε-CL and non-toxic polymeric micelles for GCV delivery can be formed.

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Section: Resultscontrasting

confidence: 51%

Ring-Opening Polymerization of ε-Caprolactone Initiated by Ganciclovir (GCV) for the Preparation of GCV-Tagged Polymeric Micelles

Sawdon

Peng

2015

Molecules

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“…In the past decades, polymeric micelles self-assembled from amphiphilic block copolymers in aqueous media have been widely investigated [1][2][3] and their excellent properties as drug delivery vehicles have been recognized such as the high stability in vivo, good biocompatibility, high drug loading, etc. [4,5].…”

Section: Introductionmentioning

confidence: 99%

Mesoscopic simulation studies on the formation mechanism of drug loaded polymeric micelles

Yan

Zhu

Zhou

et al. 2015

Colloids and Surfaces B: Biointerfaces

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“…Sawdon and Peng used acyclovir directly to initiate the polymerization of ε-caprolactone to form the hydrophobic core of acyclovir–polycaprolactone. This was further grafted with methoxy polyethylene glycol to form the amphiphilic block copolymer which could self-assemble to form the nanosized polymeric micelles in the aqueous medium [ 78 ]. These polymeric micelles were found to enhance drug-loading capacities and eliminate drug-loading steps.…”

Section: Nanotechnology Formulation Aspects and Their Application In mentioning

confidence: 99%

Nanotechnology-based antiviral therapeutics

Chakravarty

Vora

2020

Drug Deliv. and Transl. Res.

211

165

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The host immune system is highly compromised in case of viral infections and relapses are very common. The capacity of the virus to destroy the host cell by liberating its own DNA or RNA and replicating inside the host cell poses challenges in the development of antiviral therapeutics. In recent years, many new technologies have been explored for diagnosis, prevention, and treatment of viral infections. Nanotechnology has emerged as one of the most promising technologies on account of its ability to deal with viral diseases in an effective manner, addressing the limitations of traditional antiviral medicines. It has not only helped us to overcome problems related to solubility and toxicity of drugs, but also imparted unique properties to drugs, which in turn has increased their potency and selectivity toward viral cells against the host cells. The initial part of the paper focuses on some important proteins of influenza, Ebola, HIV, herpes, Zika, dengue, and corona virus and those of the host cells important for their entry and replication into the host cells. This is followed by different types of nanomaterials which have served as delivery vehicles for the antiviral drugs. It includes various lipid-based, polymer-based, lipid-polymer hybrid-based, carbon-based, inorganic metal-based, surface-modified, and stimuli-sensitive nanomaterials and their application in antiviral therapeutics. The authors also highlight newer promising treatment approaches like nanotraps, nanorobots, nanobubbles, nanofibers, nanodiamonds, nanovaccines, and mathematical modeling for the future. The paper has been updated with the recent developments in nanotechnology-based approaches in view of the ongoing pandemic of COVID-19.

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Polymeric micelles for acyclovir drug delivery

Cited by 34 publications

References 40 publications

Ring-Opening Polymerization of ε-Caprolactone Initiated by Ganciclovir (GCV) for the Preparation of GCV-Tagged Polymeric Micelles

Ring-Opening Polymerization of ε-Caprolactone Initiated by Ganciclovir (GCV) for the Preparation of GCV-Tagged Polymeric Micelles

Mesoscopic simulation studies on the formation mechanism of drug loaded polymeric micelles

Nanotechnology-based antiviral therapeutics

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