Polymeric Micelles for Drug Delivery

Croy, Scott; Kwon, Glenn S.

doi:10.2174/138161206779026245

Cited by 538 publications

(338 citation statements)

References 102 publications

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“…However, most of the polymeric materials for drug delivery are "inert" and lack of therapeutic activity. In addition, the use of large amounts of carrier materials may impose safety concerns (54). Since Ringsdorf (55) proposed the concept of "polymeric prodrug" in 1975, the utility of polymer-drug conjugates in clinical therapy has been well demonstrated.…”

Section: Peg-drug Conjugates As Dual-function Carriers For Cancer Tarmentioning

confidence: 99%

Polymeric Micelles: Nanocarriers for Cancer-Targeted Drug Delivery

2014

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Abstract. Polymeric micelles represent an effective delivery system for poorly water-soluble anticancer drugs. With small size (10-100 nm) and hydrophilic shell of PEG, polymeric micelles exhibit prolonged circulation time in the blood and enhanced tumor accumulation. In this review, the importance of rational design was highlighted by summarizing the recent progress on the development of micellar formulations. Emphasis is placed on the new strategies to enhance the drug/carrier interaction for improved drugloading capacity. In addition, the micelle-forming drug-polymer conjugates are also discussed which have both drug-loading function and antitumor activity.

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Section: Peg-drug Conjugates As Dual-function Carriers For Cancer Tarmentioning

confidence: 99%

Polymeric Micelles: Nanocarriers for Cancer-Targeted Drug Delivery

2014

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“…Micellar shells are formed by hydrophilic blocks that are exposed to aqueous medium, micellar shells facilitate the solubilisation of amphiphile in water and thus stabilise aggregates. In contrast, hydrophobic blocks form the inner micellar core, a hydrophobic domain, which facilitates the incorporation of poorly water soluble drugs by physical interaction or chemical conjugation leading to higher solubility extents (Croy et al, 2006). PEO-PPO [poly-(ethylene oxide)-poly-(propylene oxide)] block copolymers (linear poloxamers and branched poloxamines) are some of the significant commercially available micelle forming materials approved by Food and Drug Administration (Chiappetta et al, 2007).…”

Section: Figmentioning

confidence: 99%

Interaction of Nanoparticles in Biological Systems and their Role in Therapeutical Treatment of Tuberculosis and Cancer

Meena¹,

Singh²,

Sahare³

et al. 2014

JLA

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The kind of interactions which nanoparticles show in the biological systems is very interesting. Nanoparticles (NPs) on entering the living system immediately come in contact with proteins which serve many applications of nanoparticles including bio-signalling, therapeutics and drug delivery systems. Moreover, many inorganic oxide nanoparticles can also serve the purpose of antibacterial/antiviral by assisting in the production of reactive oxygen species (ROS). The role of nanoparticles in therapeutics is very significant and increasing day-by-day as it assures better treatment to the patient by enhancing activity of drug, improving bioavailability, flexibility in deciding route of administration and long term stability of drug resulting in better treatments of diseases. NPs such as solid lipid NPs, polymeric NPs, porous NPs, liposomes are being used for treatment of various types of diseases. Numerous carriers based drug delivery systems incorporating anti-TB drugs have been developed for target site actions. NPs encapsulating anti-cancer drugs such as doxorubicin, paclitaxel have also been developed for treatment of different types of cancers. Results of these studies give hopes to the researchers for the use of nanoparticles in the field of therapeutics. The NPs can be toxic as well as nontoxic to the biological system. Therefore, some adverse effects, such as, cytotoxicity on inhaling some kinds of nanoparticles must be kept in mind for judicious use of such systems during synthesis or during handling. The paper describes recent developments in the field by reviewing the available literature.

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“…в кишечной среде. Другой подход в использовании полимерных сурфактантов (для слабо растворимых неполярных лекарств) -это создание мицелл, содержащих лекарство в неполярном ядре [62]. Показано, что в таких случаях сурфактанты, проходя через неперемешивающийся водный слой в просвете кишечника, абсорбируются на мембране, повышая проницаемость и способствуя всасыванию включённого лекарства.…”

Section: повышение межклеточной проницаемости путём воздействия нащелunclassified

Bioavailability of oral drug formulations and methods for its improvement

et al. 2010

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The recent studies in nanotechnology resulted in the development of novel formulations with improved bioavailability. This is especially important for oral administered drugs as the most convenient formulations. The current review deals with the processes occurring at the gastro-intestinal (GI) tract and their influence on the drug form. The increase of bioavailability of the drug may be achieved through designing novel formulations according to the specific drug properties. They include capsules that release pharmaceutical agents at various parts of the GI tract, floating systems that prolong the presence of the drug in the GI tract, dispersed forms with surface-active soluble polymers, micelles that carry poor-soluble drugs inside their non-polar core, agents that facilitate tight junction opening, such as caprate and chitosan, and lipid-based formulations. The own data show the stimulating influence of phospholipid nanoparticles on peroral absorption of drug indomethacin in rats and on passage of transport marker and drugs through Caco-2 cell monolayer in vitro. The review summarizes current understanding of factors that influence the bioavailability of the oral drug forms, currently used models for pharmacokinetic studies, and various approaches to developing novel pharmaceutical forms that increase the bioavailability of the drugs.

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Polymeric Micelles for Drug Delivery

Cited by 538 publications

References 102 publications

Polymeric Micelles: Nanocarriers for Cancer-Targeted Drug Delivery

Polymeric Micelles: Nanocarriers for Cancer-Targeted Drug Delivery

Interaction of Nanoparticles in Biological Systems and their Role in Therapeutical Treatment of Tuberculosis and Cancer

Bioavailability of oral drug formulations and methods for its improvement

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