Polymeric micelles with anti-virulence activity against Candida albicans in a single- and dual-species biofilm

The influence of depropagation on PEGMA9 solution radical homopolymerization and copolymerization with DEAEMA: in situ1H-NMR measurements and reactivity ratio estimation by dynamic optimization

“…On the other hand, cationic bottlebrush macromolecules generated by the copolymerization of PEGMA with 2-(diethylamino) ethyl methacrylate (DEAEMA, Scheme 1) have been investigated for application in several fields, such as drug delivery in nanomedicine, 3,33 antifungal biofilms, 34 CO 2 separation, 35 water remediation, 36 stabilizers for emulsions and dispersions, 37 etc.…”

Advances in anti-invasive fungal drug delivery systems

“…Albayaty等 ［ 58 - 59 ］ 开发了用于包载伊曲康唑的酸碱度响应型胶束系统。该二嵌段聚合物胶束基于PEGMA和DEAEMA嵌段聚合体，具有很高的载药量。在白念珠菌生物膜的酸性微环境中，DEAEMA嵌段的叔胺被质子化，构象发生改变，伊曲康唑的释放增强。该胶束具有特定的大小和静电作用，对白念珠菌生物膜具有很高的亲和力，能显著抑制白念珠菌生物膜的活性，相比游离药物生物膜的生物量和活细胞数明显减少。…”

Small molecule based anti-virulence approaches against Candida albicans infections

“…Moreover, this non-lethal alternative is most suitable to the commensal C. albicans thus preserving the host microbiome. 24,100 . While the approach has a certain advantage, there are potential challenges in its clinical translation.…”