Polymeric micro/nanoparticles: Particle design and potential vaccine delivery applications

Yue, Hua; Ma, Guanghui

doi:10.1016/j.vaccine.2015.07.100

Cited by 92 publications

(76 citation statements)

References 71 publications

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“…[41][42][43][44] Exogenous nanoparticles naturally accumulate in lymphoid organs, which are populated by many DCs. [45,46] Various systems for delivery of nanoparticles, including virus-like particles, [47][48][49] liposomes, [50][51][52] polymeric nanoparticles, [53][54][55] and inorganic nanoparticles [56][57][58][59] have been often used as vaccine carriers. [45,46] Various systems for delivery of nanoparticles, including virus-like particles, [47][48][49] liposomes, [50][51][52] polymeric nanoparticles, [53][54][55] and inorganic nanoparticles [56][57][58][59] have been often used as vaccine carriers.…”

Section: Passively Targeting the Antigen-presenting Cellsmentioning

confidence: 99%

“…[30] The size, surface, charge, hydrophilicity, and administration route of nanoparticles can be altered to change their efficiency of targeting DCs. [45,46] Various systems for delivery of nanoparticles, including virus-like particles, [47][48][49] liposomes, [50][51][52] polymeric nanoparticles, [53][54][55] and inorganic nanoparticles [56][57][58][59] have been often used as vaccine carriers.…”

Section: Passively Targeting the Antigen-presenting Cellsmentioning

confidence: 99%

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Tailoring Biomaterials for Cancer Immunotherapy: Emerging Trends and Future Outlook

et al. 2017

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Cancer immunotherapy, as a paradigm shift in cancer treatment, has recently received tremendous attention. The active cancer vaccination, immune checkpoint blockage (ICB) and chimeric antigen receptor (CAR) for T-cell-based adoptive cell transfer are among these developments that have achieved a significant increase in patient survival in clinical trials. Despite these advancements, emerging research at the interdisciplinary interface of cancer biology, immunology, bioengineering, and materials science is important to further enhance the therapeutic benefits and reduce side effects. Here, an overview of the latest studies on engineering biomaterials for the enhancement of anticancer immunity is given, including the perspectives of delivery of immunomodulatory therapeutics, engineering immune cells, and constructing immune-modulating scaffolds. The opportunities and challenges in this field are also discussed.

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Section: Passively Targeting the Antigen-presenting Cellsmentioning

confidence: 99%

Section: Passively Targeting the Antigen-presenting Cellsmentioning

confidence: 99%

Tailoring Biomaterials for Cancer Immunotherapy: Emerging Trends and Future Outlook

et al. 2017

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“…Nanoparticles (NPs) have been used to incorporate (by occlusion [4], non-covalent adsorption [5] and covalent attachment [6]) different molecules (drugs [7], photosensitizers [8], biomolecules [9], antioxidants [10], and others [11]) and to release them in a controlled way. Nanoparticles have frequently been prepared using biomolecules (proteins [12], lipids [13, 14]), polymers [15, 16], metals [17, 18] and oxides such as silica [19]. …”

Section: Introductionmentioning

confidence: 99%

Morin Flavonoid Adsorbed on Mesoporous Silica, a Novel Antioxidant Nanomaterial

et al. 2016

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Morin (2´,3, 4´,5,7-pentahydroxyflavone) is a flavonoid with several beneficial health effects. However, its poor water solubility and it sensitivity to several environmental factors avoid its use in applications like pharmaceutical and cosmetic. In this work, we synthetized morin-modified mesoporous silica nanoparticles (AMSNPs-MOR) as useful material to be used as potential nanoantioxidant. To achieve this, we characterized its adsorption kinetics, isotherm and the antioxidant capacity as hydroxyl radical (HO•) scavenger and singlet oxygen (1O2) quencher. The experimental data could be well fitted with Langmuir, Freundlich and Temkin isotherm models, besides the pseudo-second order kinetics model. The total quenching rate constant obtained for singlet oxygen deactivation by AMSNPs-MOR was one order of magnitude lower than the morin rate constant reported previously in neat solvents and lipid membranes. The AMSNPs-MOR have good antioxidant properties by itself and exhibit a synergic effect with morin on the antioxidant property against hydroxyl radical. This effect, in the range of concentrations studied, was increased when the amount of morin adsorbed increased.

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“…Several main nanocarriers are used as drug delivery systems in the biomedical and pharmaceutical fields such as liposomes, polymeric micelles, dendrimers, carbon nanotubes, and polymeric nanoparticlesnanoparticles based on the usage of biodegradable polymers, such as from Polylactic acid, Polylacticco-glycolic acid and Poly caprolactone is the preformed polymer dispersion by the solvent evaporation technique 6 . The biodegradable polyester poly (DL-lactide-co-ε-caprolactone) (PLC) was used in this study for the preparation of nanospheres.…”

Section: Introductionmentioning

confidence: 99%

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2017

IJPSR

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Naproxen and Ibuprofen, two non-steroidal anti-inflammatory drugs, are frequently prescribed in modern medicine. In this study, nanoencapsulation by solvent evaporation technique is used to formulate Naproxen and Ibuprofen loaded poly(DL-lactide-co-ε-caprolactone) nanospheres by means of Tween 80 and Span 80 as surfactant and cosurfactant respectively. Different formulations are prepared with different drug masses and same quantities of polymer and surfactants. This was done in order to evaluate the effect of the mass variation of the two drugs on the characteristics of the prepared nanospheres. The prepared nanospheres are studied for drug entrapment and drug loading efficiencies, particle size, morphology, FT-IR analysis and in vitro release. As a result, all nanospheres presented a spherical profile and homogeneous size distribution. Naproxen revealed the highest drug entrapment efficiency. FT-IR analysis showed no interaction for both drugs with the polymer. In vitro release of drugs from encapsulated PLC nanospheres showed that Ibuprofen release was faster than Naproxen release. Also the in vitro release was faster for formulations having the lowest amount of drug loaded.

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Polymeric micro/nanoparticles: Particle design and potential vaccine delivery applications

Cited by 92 publications

References 71 publications

Tailoring Biomaterials for Cancer Immunotherapy: Emerging Trends and Future Outlook

Tailoring Biomaterials for Cancer Immunotherapy: Emerging Trends and Future Outlook

Morin Flavonoid Adsorbed on Mesoporous Silica, a Novel Antioxidant Nanomaterial

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