2018
DOI: 10.2174/1567201814666171019104002
|View full text |Cite
|
Sign up to set email alerts
|

Polymeric Nano-Encapsulation of Curcumin Enhances its Anti-Cancer Activity in Breast (MDA-MB231) and Lung (A549) Cancer Cells Through Reduction in Expression of HIF-1α and Nuclear p65 (Rel A)

Abstract: Our findings indicate that curcumin can effectively lower the elevated levels of HIF-1α and nuclear p65 (Rel A) in breast and lung cancer cells under an hypoxic tumour micro-environment when delivered in nanoparticulate form. This applied means of colloidal delivery could explain the improved anti-cancer efficacy of curcumin and has further potential applications in enhancing the activity of anti-cancer agents of low solubility.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

1
35
0

Year Published

2019
2019
2024
2024

Publication Types

Select...
9
1

Relationship

2
8

Authors

Journals

citations
Cited by 68 publications
(36 citation statements)
references
References 26 publications
1
35
0
Order By: Relevance
“…We calculated that the non -toxic daily dose of PIC was approximately 40 mg/kg, and a similar dose was used for both PIC and PIC-BSA NPs. The weight of each mouse was recorded on a daily basis, and colon tumor size and number were recorded post-mortem [58,59].…”
Section: Carcinogenesis Inductionmentioning
confidence: 99%
“…We calculated that the non -toxic daily dose of PIC was approximately 40 mg/kg, and a similar dose was used for both PIC and PIC-BSA NPs. The weight of each mouse was recorded on a daily basis, and colon tumor size and number were recorded post-mortem [58,59].…”
Section: Carcinogenesis Inductionmentioning
confidence: 99%
“…In order to overcome the solubility issues of curcumin and facilitate its intracellular delivery, a curcumin-loaded nanoparticle, curcumin-PLGA-NP, is synthesized. It has a tenfold increase in water solubility compared to curcumin, and shows threefold increased anti-cancer activities in human breast cancer MDA-MB-231 and NSCLC A549 cells [56]. Another curcumin-capped nanoparticle exhibits promising anti-oxidative and selective anticancer activities in human colorectal cancer HT-29 and SW-948 cells [57].…”
Section: Curcuminmentioning
confidence: 99%
“…Curcumin exerts anticancer effects through several mechanisms, which affect regulation of cell growth and apoptosis. For instance, curcumin can inhibit angiogenesis [76] as well as inhibit their proliferation and metastasis [77], decrease chronic inflammation [78] and combat mutated cancer cells [77]. Bisdemethoxycurcumin showed excellent inhibitory effects with an IC 50 value of 23.0 µM whilst the D 2 analog showed potent inhibitory effects at 8.2 µM [79].…”
Section: Myricetinmentioning
confidence: 99%