Polymeric Nanoarchitectures on Ti-Based Implants for Antibacterial Applications

Abstract

Because of the excellent mechanical properties and good biocompatibility, titanium-based metals are widely used in hard tissue repair, especially load-bearing orthopedic applications. However, bacterial infection and complication during and after surgery often causes failure of the metallic implants. To endow titanium-based implants with antibacterial properties, surface modification is one of the effective strategies. Possessing the unique organic structure composed of molecular and functional groups resembling those of natural organisms, functionalized polymeric nanoarchitectures enhance not only the antibacterial performance but also other biological functions that are difficult to accomplish on many conventional bioinert metallic implants. In this review, recent advance in functionalized polymeric nanoarchitectures and the associated antimicrobial mechanisms are reviewed.

Antibacterial Activity of Silver Doped Titanate Nanowires on Ti Implants

“…39 However, the biocompatibility of the Ti-based implants should not be ignored, especially the release of Ag + that we should pay attention to, as many works attributed the toxicity of Ag NPs to the Ag + release 45,46 and Ag + is very toxic to the human body. 18 Because of its nontoxicity and biodegradability, as a natural organic material, chitosan (CS) is usually employed to improve the bioactivity of biomaterials with a bioinert nature. In order to reduce the bioavailability and alleviate the toxicity of Ag + , CS was introduced onto the Ti surface.…”

Modification of the surface of titanium with multifunctional chimeric peptides to prevent biofilm formation via inhibition of initial colonizers

“…In order to avoid biofilmassociated infections, various strategies have been developed to improve the antimicrobial properties of biomaterial surfaces including loading with antibiotics, 31 covalent attachment of AMPs, [14][15][16] and polymer-based surface modification. [32][33][34][35] Although these methods can inhibit bacterial attachment, the procedure is tedious and has a limited efficacy in practice. To overcome these limitations and combat the issues of antibiotic resistance and toxicity, a Ti-binding protein was used to connect the multifunctional chimeric peptides with the Ti surface.…”

Electrophoretic deposition of colloidal particles on Mg with cytocompatibility, antibacterial performance, and corrosion resistance

“…It is well known that the early stage after surgery is critical to bacterial infection prevention [45]. Because once bacteria attached and formed biofilms on the surface of biomaterials, it is difficult to remove them, and this would result in implant failure and require repeated surgery [46].…”