Polymeric nanocapsules: A review on design and production methods for pharmaceutical purpose

Redox- and pH-Responsive Polymersomes with Ferrocene Moieties Exhibiting Peroxidase-like, Chemoenzymatic Activity and H2O2-Responsive Release Behavior

“…After comprehensive characterization, BCPs were dissolved in a small amount of THF and Millipore water was added dropwise to allow BCP self-assembly into polymeric vesicles. This method is referred to as emulsification-solvent diffusion . With mainly water as the dispersion medium, it can be assumed that PEG as a water-soluble polymer forms the outer shell.…”

“…This method is referred to as emulsification-solvent diffusion. 46 With mainly water as the dispersion medium, it can be assumed that PEG as a water-soluble polymer forms the outer shell. Subsequently, THF was slowly evaporated and a NaCl solution at pH 8 was added to ensure unprotonated DEAEMA monomer in order to self-assemble into uniform polymeric vesicles.…”

Skin Regenerative Potential of Cupuaçu Seed Extract (Theobroma grandiflorum), a Native Fruit from the Amazon: Development of a Topical Formulation Based on Chitosan-Coated Nanocapsules

“…RNA samples were reverse-transcribed using the High-Capacity cDNA Reverse Transcription Kit, according to the manufacturer's instructions. In summary, reverse transcription of the isolated total RNA was performed using 500 ng of the total RNA from each sample, reverse transcriptase (Superscript III, Invitrogen, Waltham, MA, USA), Oligo dT (12)(13)(14)(15)(16)(17)(18) primer (Invitrogen, Carlsbad, CA, USA), and RNAse inhibitors, reaching a final volume of 20 µL. Incubation steps were taken according to the time and temperature recommended by the manufacturer.…”

“…Nanoencapsulation holds essential advantages for topical cutaneous application [12][13][14]. Depending on the nanosystem characteristic and coating material, nanoencapsulation can promote tissue interaction and active penetration, especially for highly lipophilic compounds [14][15][16], which generally show a low penetration into the inner skin layers. In this way, bioavailability and, consequently, formulation effectiveness can be increased.…”

Strategic developments in the drug delivery of natural product dihydromyricetin: applications, prospects, and challenges

“…The pharmaceutical nanocapsule is a nanosized drug-loaded spherical particle with core-shell morphology, which has the advantages of increased solubility and stability, increased efficiency of encapsulation, the possibility of reducing adverse effects of drugs, and reduction of therapeutic doses (Frank et al., 2015 ). However, there are still many safety problems in nanocapsules, such as the surface charge that may have a toxic effect on cells and some toxic reagents involved in the preparation process, which have hindered their further application (Lima et al., 2022 ). Eudradit Rs100® polymer is a positively charged material with strong mucosal adhesion and can provide higher adhesion for positively charged bacteria (Dalcin et al., 2017 ).…”