Polymeric nanofibers for controlled drug delivery applications

Patel, Grishma; Yadav, Bindu Kumari

doi:10.1016/b978-0-12-813663-8.00004-x

Cited by 17 publications

(4 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on the FESEM image, the nanofibers were nonuniformly distributed and in cylindrical shape. Additionally, the size of the fibres formed were in nanometre range (50 nm to 1000 nm) which is around 104.65 ± 64.59 nm as shown in Table 3 [ 55 ]. Furthermore, the nylon 6,6 waste NFM has pore size approximately at 0.2 µm with high porosity of 81.34% which correlated with other literature (>80%) [ 45 , 56 ].…”

Section: Resultsmentioning

confidence: 99%

Nylon 6,6 Waste Nanofiber Membrane for Produced Water Filtration: Experimental, Performance Modelling, Optimization and Techno-Economic Analysis

et al. 2023

View full text Add to dashboard Cite

Produced water (PW) is a by-product of oil and gas extraction, of which it is deemed as the primary contributor of wastewater stream in oil production. Conventional treatment such as membrane separation is favoured due to its sustainability and cost effectiveness. On the other hand, oceanic litters such as abandoned fishing nets endangered the marine life ecosystem, despite of its potential to be raw material for fabrication of nanofiber membrane (NFM). This study explores the potential usage of electrospun nylon 6,6 waste NFM for treatment of real PW. In terms of modelling, it is found that feed concentration is the dominant factor with R2 of 0.94 for permeate concentration response and 0.91 for average flux response. Moreover, the optimized system with average flux of 216.5 L/m2h with low specific power consumption of ca. 0.09 kWh/m3 is proven to be economically feasible with less than 5% error from predicted model. As for technoeconomic analysis, it is found that permeate flux plays the major role in controlling total capital cost (CAPEX) and operating cost (OPEX) of the system. The lowest total CAPEX and OPEX to achieve 10 ppm of permeate concentration, also was found to be RM 3.7 M and RM/year 1660, hence proving the economic feasibility of the proposed system.

show abstract

Section: Resultsmentioning

confidence: 99%

Nylon 6,6 Waste Nanofiber Membrane for Produced Water Filtration: Experimental, Performance Modelling, Optimization and Techno-Economic Analysis

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Particular advantages like bulk homogeneity and minimal equipment needs are attained using this method. The polymer composition affects both fibre diameter and thickness in addition to determining the mechanical properties of nanofibers [21]. This method is frequently used to create nanocomposites for three-dimensional tissue engineering.…”

Section: Phase Separationmentioning

confidence: 99%

Revolutionizing Drug Delivery: The Role of Nanofibers - A Review

Shah,

Sapra,

Kumari

et al. 2024

jaz

View full text Add to dashboard Cite

The field of drug delivery has experienced a paradigm shift with the emergence of nanofibers as an innovative carrier system. This comprehensive review aims to delve into the multifaceted role of nanofibers in drug delivery, highlighting their unique properties and diverse applications in therapeutic interventions. Nanofibers, characterized by their high surface area-to-volume ratio and tunable properties, offer an exceptional platform for targeted and controlled drug release. Their versatile nature allows for precise engineering of size, morphology, and surface functionalities, enabling tailored drug delivery systems catering to specific therapeutic needs. This review encompasses a detailed analysis of the various fabrication techniques employed in producing nanofibers, encompassing electrospinning, self-assembly, and other advanced methodologies. Furthermore, the review presents an extensive survey of the diverse range of materials utilized in nanofiber production, such as polymers, proteins, and inorganic compounds, emphasizing their distinct advantages in drug encapsulation, protection, and release kinetics.The application spectrum of nanofibers in drug delivery is explored, spanning across various medical domains including cancer therapy, tissue engineering, wound healing, and infectious disease treatment. The review delves into recent advancements, challenges, and future prospects in this burgeoning field, underscoring the potential for nanofibers to revolutionize drug delivery strategies and improve therapeutic outcomes.In conclusion, this review underscores the pivotal role of nanofibers as a novel and promising carrier system in drug delivery, presenting a compelling case for their continued exploration and utilization in advancing medical treatments.

show abstract

“…These can be used for several administration routes, including oral, topical, transdermal, and transmucosal. Moreover, NF can protect a drug from decomposition in the body before arrival at the required target [12,13]. The combination of mechanical barriers based on non-woven nanofibrous biodegradable scaffolds and their capability for local delivery of antibiotics makes them desirable for preventing post-surgical adhesions and infections [14,15].…”

Section: Introductionmentioning

confidence: 99%

Development and Characterization of pH-Dependent Cellulose Acetate Phthalate Nanofibers by Electrospinning Technique

et al. 2021

View full text Add to dashboard Cite

The aim of this work was to obtain pH-dependent nanofibers with an electrospinning technique as a novel controlled release system for the treatment of periodontal disease (PD). Cellulose acetate phthalate (CAP) was selected as a pH-sensitive and antimicrobial polymer. The NF was optimized according to polymeric dispersion variables, polymer, and drug concentration, and characterized considering morphology, diameter, entrapment efficiency (EE), process efficiency (PE), thermal properties, and release profiles. Two solvent mixtures were tested, and CHX-CAP-NF prepared with acetone/ethanol at 12% w/v of the polymer showed a diameter size of 934 nm, a uniform morphology with 42% of EE, and 55% of PE. Meanwhile, CHX-CAP-NF prepared with acetone/methanol at 11% w/v of polymer had a diameter of 257 nm, discontinuous nanofiber morphology with 32% of EE, and 40% of PE. EE and PE were dependent on the polymer concentration and the drug used in the formulation. Studies of differential scanning calorimetry (DSC) showed that the drug was dispersed in the NF matrix. The release profiles of CHX from CHX-CAP-NF followed Fickian diffusion dependent on time (t0.43−0.45), suggesting a diffusion–erosion process and a matrix behavior. The NF developed could be employed as a novel drug delivery system in PD.

show abstract

Polymeric nanofibers for controlled drug delivery applications

Cited by 17 publications

References 80 publications

Nylon 6,6 Waste Nanofiber Membrane for Produced Water Filtration: Experimental, Performance Modelling, Optimization and Techno-Economic Analysis

Nylon 6,6 Waste Nanofiber Membrane for Produced Water Filtration: Experimental, Performance Modelling, Optimization and Techno-Economic Analysis

Revolutionizing Drug Delivery: The Role of Nanofibers - A Review

Development and Characterization of pH-Dependent Cellulose Acetate Phthalate Nanofibers by Electrospinning Technique

Contact Info

Product

Resources

About