Polymeric nanomedicines based on poly(lactide) and poly(lactide-co-glycolide)

Tong, Rong; Gabrielson, Nathan P.; Fan, Timothy M.; Cheng, Jianjun

doi:10.1016/j.cossms.2013.01.001

Cited by 46 publications

(29 citation statements)

References 128 publications

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“…In an aqueous environment, these polymers undergo degradation mediated by hydrolytic or enzymatic chain‐scission of ester bonds, whereby the degradation products can be removed from the body by regular metabolic pathways . Of particular interest in this context are copolymers such as poly(lactide‐ co ‐glycolide)s (PLGA) . Additional functions as a thermally induced shape‐memory effect (SME) open further fields of applications as minimal invasive surgeries for polyester‐based polymers …”

Section: Introductionmentioning

confidence: 99%

Atomistic Simulation of the Shape‐Memory Effect in Dry and Water Swollen Poly[(rac‐lactide)‐co‐glycolide] and Copolyester Urethanes Thereof

Ghobadi

Heuchel

Kratz

et al. 2013

Macro Chemistry & Physics

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An atomistic molecular dynamics simulation approach is applied to model the influence of urethane linker units as well as the addition of water molecules on the simulated shape‐memory properties of poly[(rac‐lactide)‐co‐glycolide] (PLGA) and PLGA‐based copolyester urethanes comprising different urethane linkers. The shape‐memory performance of these amorphous packing models is explored in a simulated heating–deformation–cooling–heating procedure. Depending on the type of incorporated urethane linker, the mechanical properties of the dry copolyester urethanes are found to be significantly improved compared with PLGA, which can be attributed to the number of intermolecular hydrogen bonds between the urethane units. Good shape‐memory properties are observed for all the modeled systems. In the dry state, the shape fixation is found to be improved by implementation of urethane units. After swelling of the copolymer models with water, which results in a reduction of their glass transition temperatures, the relaxation kinetics during unloading and shape recovery are found to be substantially accelerated.

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Section: Introductionmentioning

confidence: 99%

Atomistic Simulation of the Shape‐Memory Effect in Dry and Water Swollen Poly[(rac‐lactide)‐co‐glycolide] and Copolyester Urethanes Thereof

Ghobadi

Heuchel

Kratz

et al. 2013

Macro Chemistry & Physics

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“…60–66 Cheng and co-workers initially reported drug-initiated polymerization using a number of anticancer drugs such as paclitaxel and doxorubicin. 61–63 …”

Section: Macromolecular Sapdsmentioning

confidence: 99%

Self-assembling prodrugs

et al. 2017

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Covalent modification of therapeutic compounds is a clinically proven strategy to devise prodrugs with enhanced treatment efficacies. This prodrug strategy relies on modified drugs that possess advantageous pharmacokinetic properties and administration routes over their parent drug. Self-assembling prodrugs represent an emerging class of therapeutic agents capable of spontaneously associating into well-defined supramolecular nanostructures in aqueous solutions. The self-assembly of prodrugs expands the functional space of conventional prodrug design, providing a possible pathway to more effective therapies as the assembled nanostructure possesses distinct physicochemical properties that can be tailored to specific administration routes and disease treatment. In this review, we will discuss the various types of self-assembling prodrugs in development, providing an overview of the methods used to control their structure and function and, ultimately, our perspective on their current and future potential.

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“…Cheng and co-workers reported the method of drug-initiated polymerization and formulation of nanoconjugates as delivery vehicles [125, 126]. Paclitaxel was first used as a drug initiator to formulate PTX-polylactide (PLA) conjugates via living polymerization (Fig.…”

Section: Molecular Building Blocks For One-component Nanomedicinementioning

confidence: 99%

One-component nanomedicine

Koo

Cui

2015

Journal of Controlled Release

134

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One-component nanomedicine (OCN) represents an emerging class of therapeutic nanostructures that contain only one type of chemical substance. This one-component feature allows for fine-tuning and optimization of the drug loading and physicochemical properties of nanomedicine in a precise manner through molecular engineering of the underlying building blocks. Using a precipitation procedure or effective molecular assembly strategies, molecularly crafted therapeutic agents (e.g. polymer-drug conjugates, small molecule prodrugs, or drug amphiphiles) could involuntarily aggregate, or self-assemble into nanoscale objects of well-defined sizes and shapes. Unlike traditional carrier-based nanomedicines that are inherently multicomponent systems, an OCN does not require the use of additional carriers and could itself possess desired physicochemical features for preferential accumulation at target sites. We review here recent progress in the molecular design, conjugation methods, and fabrication strategies of OCN, and analyze the opportunities that this emerging platform could open for the new and improved treatment of devastating diseases such as cancer.

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Polymeric nanomedicines based on poly(lactide) and poly(lactide-co-glycolide)

Cited by 46 publications

References 128 publications

Atomistic Simulation of the Shape‐Memory Effect in Dry and Water Swollen Poly[(rac‐lactide)‐co‐glycolide] and Copolyester Urethanes Thereof

Atomistic Simulation of the Shape‐Memory Effect in Dry and Water Swollen Poly[(rac‐lactide)‐co‐glycolide] and Copolyester Urethanes Thereof

Self-assembling prodrugs

One-component nanomedicine

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