Polymeric nanomicelles for cancer theragnostics

Mohan, Anjusha; Nair, Shantikumar V.

doi:10.1080/00914037.2017.1309540

Cited by 12 publications

(6 citation statements)

References 83 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Besides, DOX leaks easily from PAMAM micelles because of a nondense structure, which was in line with the results of cytotoxicity and drug release studies in vitro . In addition, the free DOX had a toxic side effect . Notable cardiotoxicity (myofibril loose, nucleus degeneration, etc.)…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Zwitterionic Unimolecular Micelles with pH and Temperature Response: Enhanced In Vivo Circulation Stability and Tumor Therapeutic Efficiency

Liu

Qin

et al. 2020

Langmuir

View full text Add to dashboard Cite

Circulation stability in vivo and stimuli-responsiveness under a tumor microenvironment of the polymeric prodrug micellar drug delivery systems are very critical to improve the tumor therapeutic efficiency. In this study, a series of polyamidoamine (PAMAM)-graft-poly(2-(diethylamino) ethyl methacrylate) (PDEAEMA)-block-poly(betaine sulfonate) (PSBMA) (PDS) unimolecular micelles were prepared via atom transfer radical polymerization. PAMAM served as a hydrophobic core to load the drug, the PDMAEMA segment was a middle layer to provide both thermo- and pH-sensitivity, whereas the PSMBA shell layer was used to improve the stability of the unimolecular micelles. The PDS exhibited a spherical structure with the size of 10–20 nm at pH 7.4. PDS micelles had excellent stability to resist the large volume liquid dilution. Moreover, it exhibited excellent stability in a complex biological microenvironment because of a superhigh antiprotein adhesion capacity of the PSBMA shell layer compared with PAMAM micelles. Drug release studies confirmed that the DOX can remain in the PDS micelles at pH 7.4 and 37 °C, whereas it can rapidly be released when the pH decreases to 5.0 and/or the temperature increases to 40 °C. In vitro studies suggested that the PDS drug delivery system can effectivity induce apoptosis and inhibit the proliferation of cancer cells. In vivo studies suggested that the PDS micelles prolonged the circulation time, decreased the side effects, and increased the antitumor efficacy. Therefore, the prepared PDS micelles are a potential anticancer drug delivery carrier for cancer therapy.

show abstract

Section: Resultsmentioning

confidence: 99%

“…In addition, the free DOX had a toxic side effect. 63 Notable cardiotoxicity (myofibril loose, nucleus degeneration, etc.) can be observed in H&E staining of major organs (Figure 9).…”

Section: Stability Of Polymer Micellesmentioning

confidence: 99%

Zwitterionic Unimolecular Micelles with pH and Temperature Response: Enhanced In Vivo Circulation Stability and Tumor Therapeutic Efficiency

Liu

Qin

et al. 2020

Langmuir

View full text Add to dashboard Cite

show abstract

“…Moreover, the nanosize allows the micelles to accumulate in the tumor via the commonly referred enhanced permeability and retention (EPR) effect. 8 Nonetheless, the targeting efficiency is still limited for only utilizing EPR effect. 9 It is reported that folate receptors are over-expressed in cancer cells.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, the particles can evade from the recognition by reticuloendothelial system (RES). Moreover, the nano‐size allows the micelles to accumulate in the tumor via the commonly referred enhanced permeability and retention (EPR) effect 8 . Nonetheless, the targeting efficiency is still limited for only utilizing EPR effect 9 .…”

Section: Introductionmentioning

confidence: 99%

Design, fabrication and evaluation of redox/pH dual‐responsive micelles for tumor targeting delivery and controlled release of paclitaxel

Xu,

Liang,

et al. 2023

J of Applied Polymer Sci

View full text Add to dashboard Cite

In this study, a polymer with tumor targeting function and dual redox/pH sensitivity is designed and synthesized by integrating chitosan (CS), Poloxamer 407 (P407), cholesterol (CHO), folic acid (FA), and disulfide bonds into one molecule (P407‐CS(FA)‐SS‐CHO). The polymer can self‐assemble in water to form micelles and solubilize paclitaxel (PTX). The mean particle size of PTX‐loaded P407‐CS(FA)‐SS‐CHO micelles is 133 nm. In vitro drug release study demonstrates the acid and glutathione (GSH) triggered PTX release behavior of the micelles. In vitro and in vivo experiments demonstrate the excellent tumor growth inhibition efficacy and low systemic toxicity of the PTX‐loaded micelles. The P407‐CS(FA)‐SS‐CHO micelles will be potential intelligent drug carriers for PTX delivery.

show abstract

“…Nanoscales are being trialled for specific targeting-delivery of natural drugs, molecules, micelles, antibody, DNA, protein etc. to cancer sites in order to improve the therapeutic efficacy due to distribution specificity, increased internalisation and intracellular drug delivery that minimises side effects [15]. This above attempt of nanoparticle (NP)-natural drug formulations showcased the preclinical and clinical data related to cancer treatment [16].…”

Section: Introductionmentioning

confidence: 99%

Biophytum sensitivum nanomedicine reduces cell viability and nitrite production in prostate cancer cells

Raju

Nair

2017

IET nanobiotechnol.

Self Cite

View full text Add to dashboard Cite

Phytomedicine research received tremendous attention for novel therapeutic agent due to their safety and low cost. We assessed a novel nanoformulation of Biophytum sensitivum (BS), natural flavonoids for their improved efficacy and superior bioavailability against crude extract for prostate cancer cells (PC3). We prepared a nanomedicine of BS by nanoprecipitation method and size analysis via DLS and SEM revealed a range of 100-118 nm and surface zeta potential as −9.77 mV. FTIR was performed to evaluate functional for presence of carbonyl and aromatic rings, respectively. Human PC3 cells showed concentration at 0.5, 0.8, and 1 mg/ml dependent cytotoxicity 22, 39, and 56% for 24 h, whereas 43, 41, and 67% for 48 h of BS nanomedicine compared with crude 11, 22, and 53% for 24 h and 38, 31, and 60% for 48 h, respectively. Haemocompatibility of BS nanomedicine at the concentration of 0.5, 0.8, and 1 mg/ml did not show blood aggregation. Cellular uptake was confirmed using rhodamine-conjugated BS nanomedicine for 48 h. Interestingly, BS nanomedicine 1 mg/ml decreases the nitrite productions in PC3 cells. Collectively, BS nanomedicine has the potential anti-cancer agents with biocompatible and enhanced efficacy can be beneficial for the treatment of prostate cancer

show abstract

Polymeric nanomicelles for cancer theragnostics

Cited by 12 publications

References 83 publications

Zwitterionic Unimolecular Micelles with pH and Temperature Response: Enhanced In Vivo Circulation Stability and Tumor Therapeutic Efficiency

Zwitterionic Unimolecular Micelles with pH and Temperature Response: Enhanced In Vivo Circulation Stability and Tumor Therapeutic Efficiency

Design, fabrication and evaluation of redox/pH dual‐responsive micelles for tumor targeting delivery and controlled release of paclitaxel

Biophytum sensitivum nanomedicine reduces cell viability and nitrite production in prostate cancer cells

Contact Info

Product

Resources

About