Polymeric nanoparticles as delivery vehicles for targeted delivery of chemotherapy drug fludarabine to treat hematological cancers

Pourmadadi, Mehrab; Dehaghi, Hamed Mirzaei; Ghaemi, Amirhossein; Maleki, Hasti; Yazdian, Fatemeh; Rahdar, Abbas; Pandey, Sadanand

doi:10.1016/j.inoche.2024.112819

Inorganic Chemistry Communications

2024

DOI: 10.1016/j.inoche.2024.112819

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Polymeric nanoparticles as delivery vehicles for targeted delivery of chemotherapy drug fludarabine to treat hematological cancers

Mehrab Pourmadadi,

Hamed Mirzaei Dehaghi,

Amirhossein Ghaemi

et al.

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Cited by 9 publications

References 73 publications

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Advances in polymeric and non-polymeric nanocarriers for the magnified delivery of levofloxacin against bacterial infection

Safaran,

Javadi,

Pourmadadi

et al. 2024

J Nanopart Res

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This review examines the latest developments in nanoscopic antibiotic formulations used to treat infections caused by bacteria. A wide range of nanocarrier platforms are discussed, including polymer-based nanoparticles (NPs), lipid-based vesicles, mesoporous silica, and other inorganic materials. The antibiotic levofloxacin (LVF) is predominantly used as a model drug given its broad-spectrum activity. Studies in this regard have evaluated drug loading and encapsulation efficiency (EE) using analytical techniques such as FTIR, DLS, and TEM. In vitro release kinetics was characterized through dialysis and fluorescence-based assays. Zone of inhibition and viability studies provided insights into antibacterial efficacy. Some approaches incorporated stimuli-responsive polymers or targeting ligands to facilitate controlled or targeted drug release. Overall, the nanocarriers demonstrated potential for sustained antibiotic levels, reduced dosing, and improved treatment of biofilms and intracellular infections compared to free drug administration. The review offers a comprehensive analysis of this promising field with implications for combating antibiotic resistance.

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Advances in polymeric and non-polymeric nanocarriers for the magnified delivery of levofloxacin against bacterial infection

Safaran,

Javadi,

Pourmadadi

et al. 2024

J Nanopart Res

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Progression in nano-botanical oral hygiene solutions: The Dawn of biomimetic nanomaterials

Arif,

Khar,

Shahid

et al. 2024

European Journal of Medicinal Chemistry Reports

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Advancements in nanocarrier-mediated sunitinib delivery: Addressing obstacles and revealing its therapeutic promise in oncological treatment

Javid-Naderi,

Abbasi,

Fathi-karkan

et al. 2024

Journal of Drug Delivery Science and Technology

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Polymeric nanoparticles as delivery vehicles for targeted delivery of chemotherapy drug fludarabine to treat hematological cancers

Cited by 9 publications

References 73 publications

Advances in polymeric and non-polymeric nanocarriers for the magnified delivery of levofloxacin against bacterial infection

Advances in polymeric and non-polymeric nanocarriers for the magnified delivery of levofloxacin against bacterial infection

Progression in nano-botanical oral hygiene solutions: The Dawn of biomimetic nanomaterials

Advancements in nanocarrier-mediated sunitinib delivery: Addressing obstacles and revealing its therapeutic promise in oncological treatment

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