Polymeric Nanoparticles as Oral Delivery Systems for Encapsulation and Release of Polyphenolic Compounds: Impact on Quercetin Antioxidant Activity &amp; Bioaccessibility

Pool, Héctor; Quintanar, David; Figueroa, Juan de Dios; Bechara, Etelvino J.H.; McClements, David Julian; Mendoza, Sandra

doi:10.1007/s11483-012-9266-z

Cited by 48 publications

(16 citation statements)

References 52 publications

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“…Lipid oxidation is one of the most problematic deterioration processes occurring during the storage of aqueous-based nanoformulations containing unsaturated lipids, leading to the development of rancidity, off-flavors, and polymerization reactions. Lipid oxidation may also generate undesirable biologically active species that are involved in cardiovascular and inflammatory disease processes [27]. In emulsions, the interface between the oil and the aqueous phase is the place of contact between the lipids and hydrophilic pro-oxidative components (such as transition metal ions: iron and copper, photosensitizers, and enzymes).…”

Section: Oxidative Stability By Peroxide Valuementioning

confidence: 99%

β-Sitosterol Loaded Nanostructured Lipid Carrier: Physical and Oxidative Stability, In Vitro Simulated Digestion and Hypocholesterolemic Activity

et al. 2020

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The objective of the present study was to explore the potential of nanostructured lipid carriers (NLCs) for improving the oral delivery of β-sitosterol, a poorly water-soluble bioactive component with hypocholesterolemic activity. Two β-sitosterol formulations with different solid lipid compositions were prepared by melt emulsification, followed by the sonication technique, and the effect of storage conditions and simulated digestion on the physical, chemical and oxidative stability, bioaccessibility and release were extensively studied. Both NLC preparations remained relatively stable during the four weeks of storage at different conditions (4, 25 and 40 °C), with more superior stability at lower temperatures. The in vitro digestion experiment indicated a high physical stability after exposure to the simulated mouth and stomach stages and an improved overall β-sitosterol bioaccessibility at the end of the digestion. The NLCs presented an increased solubility and gradual release which could be justified by the remarkable affinity of β-sitosterol to the complex lipid mixture. An in vivo study demonstrated an improved reduction in the total cholesterol and low-density lipoprotein cholesterol plasma levels in mice compared with the drug suspension. These investigations evidenced the potential of the developed NLC formulations for the enhancement of solubility and in vivo performance of β-sitosterol.

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Section: Oxidative Stability By Peroxide Valuementioning

confidence: 99%

β-Sitosterol Loaded Nanostructured Lipid Carrier: Physical and Oxidative Stability, In Vitro Simulated Digestion and Hypocholesterolemic Activity

et al. 2020

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“…The in vitro digestion model used in this study was based on the report described previously (Dahan and Hoffman 2008;Pool et al 2012). This model consists of mouth, gastric and small intestinal phase and was used to determine the potential biological fate of the QT-NLC.…”

Section: In Vitro Digestion Modelmentioning

confidence: 99%

Quercetin Loaded Nanostructured Lipid Carrier for Food Fortification: Preparation, Characterization and in vitro Study

Sun

Zhao

et al. 2014

J Food Process Engineering

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Nanostructured lipid carriers (NLC) have been developed for encapsulation of bioactive flavonoids such as quercetin (QT). In this study, QT‐NLC was prepared by high‐pressure homogenization method. For the optimized QT‐NLC, the average particle size, the zeta potential and the average entrapment efficiency were 129 ± 12.13 nm, −26 ± 4 mV and 93.50 ± 0.35%, respectively. The developed QT‐NLC had good physical stability at ambient temperature condition. In vitro antioxidant activities assays showed comparable antioxidant activity of QT‐NLC to free QT. Fourier transform‐infrared spectroscopy analysis of QT‐NLC confirmed encapsulation of QT in NLC and no chemical interaction between QT and lipid matrix. Lyophilization was proved feasible for the storage of QT‐NLC dispersion. The in vitro release study in simulated gastrointestinal fluids showed a sustained release profile of QT‐NLC. The release of the QT‐NLC in simulated gastric fluids and simulated intestinal fluids was best fitted to Higuchi and Rigter‐Peppas model, respectively. The gastrointestinal tract model indicated that the bioaccessibility of QT within simulated small intestinal conditions was improved by encapsulation. The QT‐NLC also showed potential application in soft beverage. Particle size remained relatively steady in simulated beverage solutions for 2 months. It demonstrated that nanostructure lipid carriers could be designed as delivery system for encapsulation of bioactive compounds and applied in functional food industries. Practical Applications Quercetin (QT) is one of the most common dietary polyphenols widely found in the plant kingdom, which has numerous benefits to human body. But due to its low solubility and unstability when exposed to alkaline media, photo and warm temperature, its application in the food industry is limited. This research aims at incorporating QT into nanostructure lipid carriers manufactured by high‐pressure homogenization method for improved bioaccessibility and achieving its application in food such as soft beverage.

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“…Quercetin absorbs UV radiation with absorbance maxima in the UV-A ( max = 365 nm, = 28,400 mol −1 dm 3 cm −1 ) and UV-C range ( max = 256 nm, = 28,300 mol −1 dm 3 cm −1 ). However, flavonoids can also act as free-radical scavengers to prevent oxidative skin damage [30][31][32][33][34], and their topical application has met considerable interest [35][36][37][38]; generally, they are of significant interest for medicinal chemistry [39,40].…”

Section: Journal Of Chemistrymentioning

confidence: 99%

Benzophenone Suppression of Quercetin Antioxidant Activity towards Lipids under UV‐B Irradiation Regime: Detection by HPLC Chromatography

Stanojevic

Marković

Zvezdanović

2013

Journal of Chemistry

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Quercetin, a well-known flavonoid antioxidant, has been employed to control benzophenone-sensitized peroxidation of the lipid mixture in methanol solution, induced by continuous UV-B irradiation. Surprisingly, the detected quercetin antioxidant activity was almost negligible. The presented data suggests that the reason is not in its own UV-B-induced degradation but rather in its interrelationship with benzophenone during UV-B stress. On the other side of this relationship, benzophenone anticipated sensitizing role towards lipids; that is, the initiation of lipid peroxidation has been affected as well. These results, obtained by HPLC chromatography, partly confirm but partly relativize to some extent recent results obtained with the same system by spectrophotometric method.

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Polymeric Nanoparticles as Oral Delivery Systems for Encapsulation and Release of Polyphenolic Compounds: Impact on Quercetin Antioxidant Activity & Bioaccessibility

Cited by 48 publications

References 52 publications

β-Sitosterol Loaded Nanostructured Lipid Carrier: Physical and Oxidative Stability, In Vitro Simulated Digestion and Hypocholesterolemic Activity

β-Sitosterol Loaded Nanostructured Lipid Carrier: Physical and Oxidative Stability, In Vitro Simulated Digestion and Hypocholesterolemic Activity

Quercetin Loaded Nanostructured Lipid Carrier for Food Fortification: Preparation, Characterization and in vitro Study

Benzophenone Suppression of Quercetin Antioxidant Activity towards Lipids under UV‐B Irradiation Regime: Detection by HPLC Chromatography

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