Polymeric nanoparticles: Recent development in synthesis and application

Abstract

Abstract. Nanosized particles have attractive characteristics, which have received considerable attention in the last decade. Polymeric nanoparticles (PNP)s are solid particles or particulate dispersions with size in the range of 10-1000 nm. Due to the very small size, the surface area is very large so the percentage of atoms or molecules on the surface is significantly increased, which is expected to have extensive applications in various fields such as drug delivery systems, biosensors, catalysts, nanocomposites, agriculture and environment. The aim of the present paper is to critically review enhancement in the field of synthesis and different application of novel PNPs in various area from drug delivery to composite fabrication. Literature sources were mainly taken from the publications of 2011 and later; though, for a basic depiction of the structural principles, older publications have also been cited. Vol.10, No.11 (2016) 895-913 Available online at www.expresspolymlett.com DOI: 10.3144/expresspolymlett.2016.84 * Corresponding author, e-mail: mallak@cc.iut.ac.ir © BME-PT of these methods as low cost and safe ways should be highlighted. Furthermore, their importance according to their applications discusses. We will also show some properties of them such as morphology and biological activity. Keywords: biopolymers, biocomposites, polymeric nanoparticles, drug delivery systems, biosensors eXPRESS Polymer Letters

Encapsulation of hydrophobic vitamins by polylactide stereocomplexation and their release study

“…poly(amides), poly(amino acids), poly(alkyl‐α‐cyano acrylates), poly(esters), poly(orthoesters), poly(urethanes) and poly(acrylamides), have been developed during the last three decades . Among them, such aliphatic polyesters as polylactide (PLA) and polyglycolide (PGA) and their copolymers have attracted most attention due to their good biocompatibility, biodegradability and mechanical strength . Different drug delivery techniques using PLA‐ and PGA‐based materials have been elaborated, among them those focused on (nano)microparticles .…”

“…inorganic materials, [1][2][3][4] solid lipid nanoparticles [5][6][7][8][9] or micro/nanospheres produced from biodegradable polymers. [10][11][12][13][14][15] Although natural biodegradable polymers have been used to prepare various drug-loaded carriers (albumin, alginate, collagen, gelatin, chitosan, cyclodextrin, polyhydroxylalcanoates 16 ), mainly synthetic polymer formulations, e.g. poly(amides), poly(amino acids), poly(alkyl--cyano acrylates), poly(esters), poly(orthoesters), poly(urethanes) and poly(acrylamides), have been developed during the last three decades.…”

“…15,17,18 Among them, such aliphatic polyesters as polylactide (PLA) and polyglycolide (PGA) and their copolymers have attracted most attention due to their good biocompatibility, biodegradability and mechanical strength. 12,15,19,20 Different drug delivery techniques using PLA-and PGA-based materials have been elaborated, among them those focused on (nano)microparticles. 12,15 Methods such as solvent evaporation/solvent extraction implemented by single or double emulsion methods ('oil-in-water', 'water-in-oil-in-water') and spray drying (solvent displacement) have been most frequently applied in the case of PLA and PLA/PGA polymers.…”

“…12,15,19,20 Different drug delivery techniques using PLA-and PGA-based materials have been elaborated, among them those focused on (nano)microparticles. 12,15 Methods such as solvent evaporation/solvent extraction implemented by single or double emulsion methods ('oil-in-water', 'water-in-oil-in-water') and spray drying (solvent displacement) have been most frequently applied in the case of PLA and PLA/PGA polymers. 15 The choice of preparation method of the drug carrier depends on the applied polymer, the drug, and the type and the duration of the therapy.…”

“…15 The choice of preparation method of the drug carrier depends on the applied polymer, the drug, and the type and the duration of the therapy. [10][11][12][13][14][15][16] To meet numerous requirements concerning the desired size of the particles, their stability and the needed degradation profile, the existing preparation methods are still being modified and new methods are sought.…”