Polymeric nanoparticles: the future of nanomedicine

Banik, Brittany L.; Fattahi, Pouria; Brown, Justin L.

doi:10.1002/wnan.1364

Cited by 386 publications

(251 citation statements)

References 227 publications

(251 reference statements)

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“…Nanoparticles may be engineered from biological macromolecules (proteins, DNA, RNA), lipids, polymers, semiconductors, metals, or a vast number of possible combinations of these components . Protein, DNA, and RNA based nanoparticles are often engineered from human viruses, plant viruses, and bacteriophages .…”

Section: Types Of Nanoparticlesmentioning

confidence: 99%

Cryo‐electron microscopy and cryo‐electron tomography of nanoparticles

Stewart

2016

WIREs Nanomed Nanobiotechnol

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Cryo-transmission electron microscopy (cryo-TEM or cryo-EM) and cryo-electron tomography (cryo-ET) offer robust and powerful ways to visualize nanoparticles. These techniques involve imaging of the sample in a frozen-hydrated state, allowing visualization of nanoparticles essentially as they exist in solution. Cryo-TEM grid preparation can be performed with the sample in aqueous solvents or in various organic and ionic solvents. Two-dimensional (2D) cryo-TEM provides a direct way to visualize the polydispersity within a nanoparticle preparation. Fourier transforms of cryo-TEM images can confirm the structural periodicity within a sample. While measurement of specimen parameters can be performed with 2D TEM images, determination of a three-dimensional (3D) structure often facilitates more spatially accurate quantization. 3D structures can be determined in one of two ways. If the nanoparticle has a homogeneous structure, then 2D projection images of different particles can be averaged using a computational process referred to as single particle reconstruction. Alternatively, if the nanoparticle has a heterogeneous structure, then a structure can be generated by cryo-ET. This involves collecting a tilt-series of 2D projection images for a defined region of the grid, which can be used to generate a 3D tomogram. Occasionally it is advantageous to calculate both a single particle reconstruction, to reveal the regular portions of a nanoparticle structure, and a cryo-electron tomogram, to reveal the irregular features. A sampling of 2D cryo-TEM images and 3D structures are presented for protein based, DNA based, lipid based, and polymer based nanoparticles. WIREs Nanomed Nanobiotechnol 2017, 9:e1417. doi: 10.1002/wnan.1417 For further resources related to this article, please visit the WIREs website.

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Section: Types Of Nanoparticlesmentioning

confidence: 99%

Cryo‐electron microscopy and cryo‐electron tomography of nanoparticles

Stewart

2016

WIREs Nanomed Nanobiotechnol

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“…There are a number of non-biodegradable polymers such as poly(methyl methacrylate) (PMMA), poly(acrylamide), poly(styrene), and poly(acrylates), (Banik et al 2016); however, chronic toxicity has been observed in studies using these materials. This has led a focus on biodegradable polymers (Burman et al 2015), examples of which include synthetic polymers such as poly(lactide) (PLA), poly(lactide-coglycolide) copolymers (PLGA), poly(ε-caprolactone) (PCL), and 17 and poly(amino acids) (Elsabahy and Wooley 2012).…”

Section: Polymeric Nanoparticlesmentioning

confidence: 99%

The use of nanotechnology in cardiovascular disease

2018

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Cardiovascular diseases claim a number of lives globally; many of which are preventable. With the increase in diets that consist of high saturated fat, salt, and sugar, people often living sedentary lifestyles, and a rise in cases of obesity, the incidence of cardiovascular disease is increasing. These contributing factors, coupled with more advanced methods of diagnosis, have delivered statistics that clearly show that there is a rising trend in the prevalence of cardiovascular disease. Treatment for cardiovascular diseases is limited currently to oral medicines or invasive surgery. There is a huge gap in this area of medicine for novel therapeutics for improved patient outcomes. Nanotechnology may provide a solution to more effective treatment of disease, with better prognoses and a reduced side effect profile. This review will explore for potential solutions to the limited pharmacological therapies currently on the market and the future that lies ahead for the place of nanotechnology within cardiovascular medicine.

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“…[1] Of particular interest is the ability to adapt www.advancedsciencenews.com www.advtherap.com Figure 3. [19,20] To further develop the utility of copolymers, an important consideration is biocompatibility, which can be imparted through the use of biodegradable subunits such as polyesters and polycarbonates. Reproduced with permission.…”

Section: Polymeric Nanoparticles As Therapeutic Platformsmentioning

confidence: 99%

“…[1] Copyright 2017, Elsevier. [18,19,24] The porosity of polymersomes has also been established by the insertion of channel proteins, such as OmpF or Aquaporin Z, creating channels for selective molecular transportation. Although there has been substantial progress toward the generation of polymersomes for biological applications, this is usually accomplished via the self-assembly of nonbiocompatible/degradable components comprising building blocks such as polystyrene (PS) and poly(dimethyl siloxane) (PDMS).…”

Section: Polymeric Nanoparticles As Therapeutic Platformsmentioning

confidence: 99%

Adaptive Polymersome and Micelle Morphologies in Anticancer Nanomedicine: From Design Rationale to Fabrication and Proof‐of‐Concept Studies

Pijpers

Abdelmohsen

Xia

et al. 2018

Advanced Therapeutics

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Intrigued and inspired by the intricacy of natural architectures which display various morphologies, researchers seek to develop artificial counterparts in order to replicate, and thereby harness, their function for diverse applications. In particular, well-defined nanoparticles with various morphologies are of great interest for biomedical research. The impact of morphologically discrete nanoparticles upon the development of nanomedicine is significant, gaining increasing attention for its potential to provide a new avenue for the development of future therapeutic technologies. This progress report discusses adaptive morphologies based on block copolymers as platforms for therapeutic and smart drug delivery applications, including design rationale and controlling the morphology of polymeric nanoparticles. The proof-of-concept studies on influence of shapes of nanoparticles on their anticancer effects in vitro and in vivo are addressed.

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Polymeric nanoparticles: the future of nanomedicine

Cited by 386 publications

References 227 publications

Cryo‐electron microscopy and cryo‐electron tomography of nanoparticles

Cryo‐electron microscopy and cryo‐electron tomography of nanoparticles

The use of nanotechnology in cardiovascular disease

Adaptive Polymersome and Micelle Morphologies in Anticancer Nanomedicine: From Design Rationale to Fabrication and Proof‐of‐Concept Studies

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