Polymeric Nanostructures for Imaging and Therapy

Elsabahy, Mahmoud; Heo, Gyu Seong; Lim, Soon-Mi; Sun, Guorong; Wooley, Karen L.

doi:10.1021/acs.chemrev.5b00135

Cited by 441 publications

(357 citation statements)

References 346 publications

(700 reference statements)

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“…When understanding the molecular mechanism of various cancers and combining the advances in the design of therapeutic nanostructures, high efficiency of the treatment of cancer and improved compliance of patients can be achieved. 20,74 The application of nanomaterials, especially the polymeric nanostructures, in the treatment of colon cancer has indicated the efficacy of enhancing the delivery of therapeutic agents to the targeted sites. A series of polymeric nanostructures, such as polymeric NPs, polymeric micelles, dendrimers, polymersomes, polymer hybrid systems, and polymer-drug/protein conjugates (Fig.…”

Section: Nanostructure Requirements For Colon Cancer Therapymentioning

confidence: 99%

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Polymeric nanoparticles for colon cancer therapy: overview and perspectives

et al. 2016

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Section: Nanostructure Requirements For Colon Cancer Therapymentioning

confidence: 99%

“…4), have recently been developed for targeted delivery of therapeutics in cancer therapy. 64,74 Polymeric NPs consist of a solid sphere structure which is produced via a self-assembly process. They include nanospheres and nanocapsules due to the different modes of formation of the nanoparticles.…”

Section: Nanostructure Requirements For Colon Cancer Therapymentioning

confidence: 99%

Polymeric nanoparticles for colon cancer therapy: overview and perspectives

et al. 2016

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“…41,42 A new class of nanoparticles, polymeric nanoparticles, has been touted for various biomedical applications due to the versatility in modification to incorporate different functionalities. 15,43–45 Nederberg et al synthesized polymeric nanoparticles consisting of cationic amphiphilic triblock polycarbonates that selectively lysed microbial membranes. 46 They were not only biodegradable but also in vivo applicable and highly effective against drug-resistant bacteria.…”

Section: Introductionmentioning

confidence: 99%

Charged Metallopolymer-Grafted Silica Nanoparticles for Antimicrobial Applications

Pageni¹,

Yang²,

Chen³

et al. 2018

Biomacromolecules

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Inappropriate and frequent use of antibiotics has led to the development of antibiotic-resistant bacteria, which cause infectious diseases that are difficult to treat. With the rising threat of antibiotic resistance, the need to develop effective new antimicrobial agents is prominent. We report antimicrobial metallopolymer nanoparticles, which were prepared by surface-initiated reversible addition–fragmentation chain transfer polymerization of a cobaltocenium-containing methacrylate monomer from silica nanoparticles. These particles are capable of forming a complex with β-lactam antibiotics, such as penicillin, rejuvenating the bactericidal activity of the antibiotic. Disk diffusion assays showed significantly increased antibacterial activities against both Gram-positive and Gram-negative bacteria. The improved efficiencies were attributed to the inhibition of hydrolysis of the β-lactam antibiotics and enhancement of local antibiotics concentration on a nanoparticle surface. In addition, hemolysis evaluations demonstrated minimal toxicity to red blood cells.

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“…Colloidal nanosystems for drug delivery alter the pharmacokinetics of numerous drugs, which can often improve their therapeutic indexes [83]. These colloids are usually spherical, submicron in size, stable in bodily fluids, biodegradable, and have no systematic toxicity or immune response.…”

Section: Conventional (Non-living) Radical Polymerizationsmentioning

confidence: 99%

Radical Polymerization of Alkyl 2-Cyanoacrylates

2018

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Cyanoacrylates (CAs) are well-known fast-setting adhesives, which are sold as liquids in the presence of stabilizers. Rapid anionic polymerization on exposure to surface moisture is responsible for instant adhesion. The more difficult, but synthetically more useful radical polymerization is only possible under acidic conditions. Recommendations on the handling of CAs and the resulting polymers are provided herein. In this review article, after a general description of monomer and polymer properties, radical homo- and copolymerization studies are described, along with an overview of nanoparticle preparations. A summary of our recently reported radical polymerization of CAs, using reversible addition-fragmentation chain transfer (RAFT) polymerization, is provided.

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Polymeric Nanostructures for Imaging and Therapy

Cited by 441 publications

References 346 publications

Polymeric nanoparticles for colon cancer therapy: overview and perspectives

Polymeric nanoparticles for colon cancer therapy: overview and perspectives

Charged Metallopolymer-Grafted Silica Nanoparticles for Antimicrobial Applications

Radical Polymerization of Alkyl 2-Cyanoacrylates

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