Polymeric Thin Film Technology for Neural Interfaces: Review and Perspectives

Riggio, Cristina; Ciofani, Gianni; Raffa, Vittoria; Bossi, Silvia; Micera, Silvestro; Cuschieri, Alfred

doi:10.5772/8396

Cited by 2 publications

(1 citation statement)

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“…Permeability of alginate microfibers encapsulating colloidal particles, bacteria and nanoparticles [34], endothelial cells [35,36] has also been proven as a result of biomarkers release. Albumin release from a 5 micron alginate coating adsorbed onto carbon nanotubes has also been characterized with 100% of the entrapped albumin released within 9 hrs of hydration in cell culture media [37]. Mathematical models to describe the diffusion of solutes or drugs from a membrane have been reported in the literature, in both spherical [13] and cylindrical [19] [19,38].…”

Section: Discussionmentioning

confidence: 99%

Modeling Diffusivity Through Alginate-Based Microfibers: A Comparison of Numerical and Analytical Models Based on Empirical Spectrophotometric Data

Djomehri

Mobed-Miremadi

Keralapura

2013

J. Memb. Separ. Tech.

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The study of mass transport across hollow and solid 3D microfibers to study metabolic profiles is a key aspect of tissue engineering approach. A new modified numerical mathematical model based on Fickian equations in cylindrical coordinates has been proposed for determining the membrane diffusivity of 2% (w/v) alginate-based stents cross-linked with 10% CaCl2. Based on the economical and direct spectrophotometric measurements, using this model, inward diffusivities ranging from 5.2x10-14 m 2 /s 2.93x10-12 m 2 /s were computed for solutes with Stokes radii ranging between 0.36 to 3.5 nm, diffusing through bare alginate and alginate-chitosan-alginate microfibers. In parallel an analytical solution to the cylindrical Fickian equation was derived to validate the numerical solution using experimental diffusion data from a solid stent. Excellent agreement was found between the numerical and analytical models with a maximum calculated residual value of 4%. Using these models, a flexible computational platform is proposed to conduct custom diffusion and MW cut-off characterization across micro-porous microfibers not limited to alginate in composition.

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