Polymeric wound dressings, an insight into polysaccharide-based electrospun membranes

Gruppuso, Martina; Turco, Gianluca; Marsich, Eleonora; Porrelli, Davide

doi:10.1016/j.apmt.2021.101148

Cited by 56 publications

(49 citation statements)

References 502 publications

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“…Due to the complexity of chronic wounds, it is difficult for wound dressings with a single-function to address all the problems in chronic wounds. 32,34 A meta-analysis of controlled studies on chronic wounds showed that although the use of advanced wet dressings (hydrocolloids, hydrogels, etc.) increased healing rates by 52% compared to dry traditional dressings (gauze, etc.…”

Section: Main Functions Of Multifunctional Wound Dressingsmentioning

confidence: 99%

Construction of multifunctional wound dressings with their application in chronic wound treatment

Long

Liu

et al. 2022

Biomater. Sci.

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Section: Main Functions Of Multifunctional Wound Dressingsmentioning

confidence: 99%

Construction of multifunctional wound dressings with their application in chronic wound treatment

Long

Liu

et al. 2022

Biomater. Sci.

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“…These dressings are not indicated for dry wounds or eschars treatment, because they can adhere to the wound bed causing pain and secondary wounds. 46 Hydrocolloids are polymeric and elastic hydrogels processed with synthetic rubbers and mucilages such as carboxymethyl cellulose, suitable for use in difficult areas such as sacrum, heel, and elbow. They can stimulate angiogenesis and remain in the wound bed for 5-7 days.…”

Section: Wound Dressingmentioning

confidence: 99%

Alginate/polyvinyl alcohol films for wound healing: Advantages and challenges

et al. 2022

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The skin is the largest organ in the human body and its physical integrity must be maintained for body homeostasis and to prevent the entry of pathogenic microorganisms. Sodium alginate (SA) and polyvinyl alcohol (PVA) are two polymers widely used in films for wound dressing applications. Furthermore, blends between SA and PVA improve physical, mechanical and biological properties of the final wound healing material when compared to the individual polymers. Different drugs have been incorporated into SA/PVA-based films to improve wound healing activity. It is noteworthy that SA/PVA films can be crosslinked with Ca 2+ or other agents, which improves physicochemical and biological properties. Thus, SA/PVA associations are promising for the biomedical field, as a potential alternative for wound treatment. This review focuses on the main techniques for obtaining SA/PVA films, their physical-chemical characterization, drug incorporation, and the advantages and challenges of these films for wound healing.

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“…Hydrophilic polymers, such as polysaccharides [ 5 ], could be considered suitable for this application. In literature, it is described the preparation of films based on polysaccharides such as agarose [ 6 ], alginate [ 7 ], that coming from marine algae [ 8 ], and cellulose [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Wound Dressing: Combination of Acacia Gum/PVP/Cyclic Dextrin in Bioadhesive Patches Loaded with Grape Seed Extract

Pagano

Luzi²,

Ricci

et al. 2022

Pharmaceutics

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The success of wound treatment is conditioned by the combination of both suitable active ingredients and formulation. Grape seed extract (GSE), a waste by-product obtained by grape processing, is a natural source rich in many phenolic compounds responsible for antioxidant, anti-inflammatory, and antimicrobial activities and for this reason useful to be used in a wound care product. Bioadhesive polymeric patches have been realized by combining acacia gum (AG) and polyvinylpyrrolidone (PVP). Prototypes were prepared by considering different AG/PVP ratios and the most suitable in terms of mechanical and bioadhesion properties resulted in the 9.5/1.0 ratio. This patch was loaded with GSE combined with cyclic dextrin (CD) to obtain the molecular dispersion of the active ingredient in the dried formulation. The loaded patch resulted mechanically resistant and able to release GSE by a sustained mechanism reaching concentrations able to stimulate keratinocytes’ growth, to exert both antibacterial and antioxidant activities.

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Polymeric wound dressings, an insight into polysaccharide-based electrospun membranes

Cited by 56 publications

References 502 publications

Construction of multifunctional wound dressings with their application in chronic wound treatment

Construction of multifunctional wound dressings with their application in chronic wound treatment

Alginate/polyvinyl alcohol films for wound healing: Advantages and challenges

Wound Dressing: Combination of Acacia Gum/PVP/Cyclic Dextrin in Bioadhesive Patches Loaded with Grape Seed Extract

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