2021
DOI: 10.1039/d0sc04750c
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Polymerizable Gd(iii) building blocks for the synthesis of high relaxivity macromolecular MRI contrast agents

Abstract: A new synthetic strategy for the preparation of efficient macromolecular MRI contrast agents is reported.

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Cited by 13 publications
(20 citation statements)
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“…58–60 Moreover, the same Gd-complex incorporated in linear 4-acryloylmorpholine (NAM) copolymers, p(NAM- r -Gd·L 1 ), at different molar proportions of Gd·L 1 (1 to 17 mol%) showed higher relaxivities, ranging from 17 to 18.4 mM −1 s −1 (at 30 MHz and 298 K). 57 A similar r 1 value was observed in the case of a GdDOTA-monoamide-functionalized mesoporous silicas SBA-15 (6.1 mM −1 s −1 at 30 MHz and 310 K); 61 in that case the authors highlighted the presence of a large number ( ca. 80%) of Gd-complex inside the pores of the hybrid material through which the water diffusion was reduced, lowering thus the overall relaxivity.…”
Section: Resultssupporting
confidence: 66%
See 1 more Smart Citation
“…58–60 Moreover, the same Gd-complex incorporated in linear 4-acryloylmorpholine (NAM) copolymers, p(NAM- r -Gd·L 1 ), at different molar proportions of Gd·L 1 (1 to 17 mol%) showed higher relaxivities, ranging from 17 to 18.4 mM −1 s −1 (at 30 MHz and 298 K). 57 A similar r 1 value was observed in the case of a GdDOTA-monoamide-functionalized mesoporous silicas SBA-15 (6.1 mM −1 s −1 at 30 MHz and 310 K); 61 in that case the authors highlighted the presence of a large number ( ca. 80%) of Gd-complex inside the pores of the hybrid material through which the water diffusion was reduced, lowering thus the overall relaxivity.…”
Section: Resultssupporting
confidence: 66%
“…Previously, we demonstrated that decreasing the tumbling rate of MRI-active gadolinium(III) complexes, through incorporation into polymers, significantly increases the relaxivity of contrast agents, potentially decreasing the required dose in MRI imaging. 57 The current work details copolymerisation of one of our previously reported monomeric Gd(III) complexes, Gd•L 1 , into the shell of spherical p(MMA) particles (Fig. 5).…”
Section: Polymer Chemistry Papermentioning
confidence: 93%
“…Nearly all monomers applicable to ATRP could be polymerized well by RAFT with narrow molecular weight distribution. Actually, depending on the activating substituents, the whole gamut of vinyl monomers, including functional ligands [ 36 , 37 , 38 , 39 ] and functional (metal) complexes [ 18 , 40 , 41 ], can be polymerized in a controlled manner by RAFT, leading to polymers with low dispersity.…”
Section: Synthetic Methods Of Linear Polymers With Precisely Controll...mentioning
confidence: 99%
“…We have prepared gadolinium complexes bearing two polymerisable arms, which can be readily polymerised in a single step to form macromolecules with different architec tures, such as hyperbranched polymers. 9 By limiting the local motion of the gadolinium complex through crosslinking, we have produced contrast agents with 8fold higher relaxivities compared to commercial agents (e.g. GdDOTA), which could enable lower and safer doses of the contrast agent to be used.…”
Section: Young Career Focus Synformmentioning
confidence: 99%