Polymerization-Induced Phase Separation Using Hydrogen-Bonded Supramolecular Polymers

Keizer, Henk M.; Sijbesma, Rint P.; Jansen, J. F. G. A.; Pasternack, G.; Meijer, E. W.

doi:10.1021/ma034284u

Cited by 48 publications

(73 citation statements)

References 36 publications

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“…68 Furthermore, the group of van Hest showed the synthesis of nucleobase-functionalized block copolymers via atom-transfer radical polymerization of thymine, adenine, cytosine, and guanine nucleobase-functional methacrylates. 69,70 The quadruple hydrogen-bonding UPy-unit, developed in our group, has been further employed in the functionalization of several low molecular weight polymers, such as poly-(dimethylsiloxanes) (PDMS), 41,71 poly(ethylene butylenes) (PEB), [72][73][74] poly(ethers), 72,75,76 poly(carbonates), 72,77 poly-(styrenes) (PS), 78 poly(isoprenes) (PI), 78 poly(ethylene-copropylenes) (PE-co-PP), 79 and poly(esters) 28,72,80,81 (Table 1). a) The compound numbers correspond to the numbers in Fig.…”

Section: The Biomaterialsmentioning

confidence: 99%

“…72 UPy-polyether 6c and UPy-polycarbonate 6d were used in ''supramolecular'' PIPS (polymerization-induced phase separation), as described below (Section 3.4). 76 Upon UPyfunctionalization of PTMC prepolymers, the viscous liquids become strong and flexible materials, 6e and 6f. Tunability of the mechanical and thermal properties was achieved by mixing these bifunctional UPy-PTMCs with different trifunctional UPy-PTMCs, 8b-8d.…”

Section: The Biomaterialsmentioning

confidence: 99%

“…24). 76 In PIPS, a polymer is dissolved in a reactive monomer which is subsequently polymerized, e.g. by UV-irradiation, to cause phase separation resulting in two polymeric phases with certain morphology.…”

Section: 8082mentioning

confidence: 99%

“…The mechanical behaviour of materials obtained by fast UV-curing (0.3 s) of solutions of UPy-modified polymers in acrylates was comparable to high molecular weight analogues. 76 A different application in which the dramatic differences in phase behaviour of supramolecular polymers in a relatively narrow temperature range can be used is ink-jet printing. By the ejection of ink droplets through a small orifice, images can be created on a certain substrate, i.e.…”

Section: 8082mentioning

confidence: 99%

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Supramolecular Biomaterials. A Modular Approach towards Tissue Engineering

Dankers

Meijer²

2007

Bulletin of the Chemical Society of Japan

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123

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Supramolecular chemistry is an exciting area of science that plays a central role in bringing different disciplines together, ranging from molecular medicine to nanotechnology. Materials science based on supramolecular interactions is an emerging field, which has made important steps forward in the past ten years. The self-assembly of small synthetic molecules into long-chain architectures gives rise to the careful design of supramolecular polymers or fibers based on highly directional, reversible, non-covalent interactions. Much afford is put into the development of supramolecular (polymeric) materials with true materials properties, both in solution and in the solid state. These supramolecular materials are beginning to reach the market in all kind of applications. The field of regenerative medicine in general and that of tissue engineering in particular is one of the most challenging areas in which supramolecular materials might have a high potential. In tissue engineering, the biological environment and the interactions of cells with the artificial biomaterial is of utmost importance for the functioning of the implant, i.e. the engineered tissue. Ideal biomaterials do not only have to fulfil the biomaterials trinity of tuneable mechanical properties, regulation of the degradability and the ease for bioactivity incorporation, but also have to mimic the natural environment where the materials are brought into. Therefore, a modular, self-assembly approach using several supramolecular building blocks is an exquisite way to produce such ''responsive'' biomaterials. It is proposed that the artificial materials described in this account have the same type of dynamic ability to adapt its biofunctionality as is so well known for the living cells in the host tissue. This account will highlight two systems, i.e. self-assembling oligopeptide fibers as pioneered by Stupp et al. and Zhang et al., and our hydrogen-bonded supramolecular polymers, to show the potential of a modular approach to dynamic biomaterials for tissue engineering.

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Section: The Biomaterialsmentioning

confidence: 99%

Section: The Biomaterialsmentioning

confidence: 99%

Section: 8082mentioning

confidence: 99%

Section: 8082mentioning

confidence: 99%

See 2 more Smart Citations

Supramolecular Biomaterials. A Modular Approach towards Tissue Engineering

Dankers

Meijer²

2007

Bulletin of the Chemical Society of Japan

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123

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“…149 The ease of UPy-moiety synthesis facilitates large-scale production of supramolecular polymers, with interesting material properties. Many examples have been published, including telechelically UPy-functionalized polydimethylsilanes (PDMS), 149,152 poly(ethylenebutylenes) (PEB), [153][154][155] polyethers, 153,156,157 polycarbonates, 153,158 polystyrenes (PS), 159 and polyesters. 153,[160][161][162] Upon UPy-functionalization, the material properties change dramatically.…”

Section: Ureido-pyrimidinone-based Supramolecular Polymersmentioning

confidence: 99%

Advances in the Development of Supramolecular Polymeric Biomaterials

Goor

Dankers²

2017

Comprehensive Supramolecular Chemistry II

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Scanning Electron Microscopy

Zhao

2012

Supramolecular Chemistry

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Scanning Electron MicroscopyWith the increasing number of advanced imaging tools available, the utility of conventional imaging techniques is often overlooked. In fact, the ability to visualize structures with the high resolution achieved by using electron microscopes provides the foundation for developing valid conclusions about functional relationships. Despite advances in other types of light (LM), atomic force microscopy (AFM), and electron microscopy (EM), scanning electron microscopy (SEM) remains distinct in its ability to examine dimensional topography and distribution of exposed features. The ultimate resolution achieved is controlled both by optimizing specimen preparation and instrumental parameters.Preservation of biological structures in a manner that prevents decay under the high vacuum necessary for a mean free path of travel for the electron beam is a primary concern. Biological specimens are generally composed of non-conductive, thermally sensitive, fragile material which if not stabilized results in specimen damage and imaging artifacts. Specimens can be prepared through chemical and physical (i.e. cryo-preservation) methods or both. Although cryo-preservation may be the preferred method for optimal near native NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript state preservation, it requires expensive instrumentation, advanced skills, and is not necessary to address many scientific questions. In general, preparation of specimens for examination by SEM requires stabilization of structures as described in Basic Protocol 1, then dehydration of specimens as described in Basic Protocol 2, and finally, ensuring adequate conductivity as discussed in Basic Protocol 3, or their respective alternatives.Specifically, Basic Protocol 1 provides some protocols and tips for chemical preservation of animal tissues and cells, bacteria, viruses, and macromolecular specimens. Basic Protocol 2 provides options for specimen mounts and critical point or chemical drying, and Basic Protocol 3 addresses the rationale for metal coating and alternatives. Additional techniques for immune-labeling strategies with special considerations for correlative techniques are outlined in Basic Protocol 4, and "affordable" specimen fracture is discussed in Basic Protocol 5. Basic Protocol 6 describes stereo pair and anaglyph generation to produce 3-dimensional (3-d) images. The Commentary section discusses basic theory and application for both preparative and imaging techniques of biological specimens for SEM and offers a troubleshooting guide for common problems.There is no one method or condition that assures successful preparation and imaging for all biological specimens, thus the user should be willing to experiment with preparative and imaging techniques and technologies to achieve the desired results. The content of this Unit is not meant to be exhaustive, but rather offers a starting point for biological specimen preparation and imaging by SEM. Safety ConsiderationsPreparation of biological specimens f...

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Polymerization-Induced Phase Separation Using Hydrogen-Bonded Supramolecular Polymers

Cited by 48 publications

References 36 publications

Supramolecular Biomaterials. A Modular Approach towards Tissue Engineering

Supramolecular Biomaterials. A Modular Approach towards Tissue Engineering

Advances in the Development of Supramolecular Polymeric Biomaterials

Scanning Electron Microscopy

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