Polymerizations of Multifunctional Anhydride Monomers to Form Highly Crosslinked Degradable Networks

Development and characterization of degradable thiol-allyl ether photopolymers

“…This equation accounts for the initial network composition, the extent of primary cycle formation, and the extent of degradation. (2) Here, W SH4 and W SH2 are the polymer weight fractions contributed by the degradable tetra and di functional thiol monomers; W SH2′ is the weight fraction contributed by the nondegradable dithiol monomer; W ene is the weight fraction contributed by the ene monomer; x and y are the probabilities that an ene or a thiol functional group, respectively, are part of a finite network and are not part of a cycle; f SH4,4 , f SH4,2 , and f SH4,0 are the fractions of degradable tetrathiol monomer that contain 0, 1, and 2 primary cycles, respectively; f SH2,0 and f SH2,2 are the fractions of degradable dithiol monomer molecules that are either part or not part of a primary cycle, respectively; f SH2′,0 and f SH2′,2 are the fractions of nondegradable dithiol monomers that are either part or not part of a primary cycle, respectively; f ene2 , is the fraction of ene monomers which are not part of a primary cycle; f ene1 , is the fraction of ene monomers which are part of a cycle on a thiol monomer that contains 1 cycle; f ene0 is the fraction of ene monomers which are part of a cycle on a thiol monomer that contains 2 cycles; and P is the fraction of esters in the network that have degraded.…”

“…In response to this demand, much research has focused on developing new biomaterials or improving existing systems. [1][2][3][4][5][6][7][8][9][10][11][12] While the design criteria driving this research cover as broad a range of material properties as diverse as the array of end-applications, they also share some common goals. Included among these goals is the desire to create biocompatible materials that have tunable material properties which allow optimal tissue regeneration and controllable drug delivery.…”

Degradable thiol-acrylate photopolymers: polymerization and degradation behavior of an in situ forming biomaterial

“…For example, highly crosslinked networks formed from low-molecular-weight, hydrophobic dimethacrylated polyanhydrides degrade through a surface erosion mechanism while moderately crosslinked hydrogels formed from high-molecular-weight, hydrophilic dimethacrylated poly(lactic acid)-b-poly(ethylene glycol)-b-poly(lactic acid) (PEG-PLA) undergo bulk erosion [21][22][23]. Another example is the ability to tailor the mechanical strength and modulus of oligo(poly (ethylene glycol) fumarate) hydrogels through modifications of the PEG molecular weight [24], crosslinker mole fraction [25], and porogen content [26].…”

Development of Proteinaceous Plywood Adhesive and Optimization of Its Lap Shear Strength

“…SRM proteins contain an array of functional groups (NH 2 , OH, SH, COOH) associated with their amino acids that provide the possibility of chemical cross‐linking with several agents. In general, cross‐linked intact proteins are characterized by improved mechanical, thermal, moisture, and chemical resistance properties in comparison to their non‐cross‐linked and linear analogues . Previous research demonstrated that the cross‐linking of proteins, such as gelatin, with a combination of resorcinol and formaldehyde and a combination of resorcinol and glutaraldehyde could be used to provide tissue adhesion for biomedical applications .…”