2024
DOI: 10.1021/acs.biomac.4c00850
|View full text |Cite
|
Sign up to set email alerts
|

Polymers for Disrupting Protein–Protein Interactions: Where Are We and Where Should We Be?

Stephanie P. Le,
Jithu Krishna,
Prachi Gupta
et al.

Abstract: Protein–protein interactions (PPIs) are central to the cellular signaling and regulatory networks that underlie many physiological and pathophysiological processes. It is challenging to target PPIs using traditional small molecule or peptide-based approaches due to the frequent lack of well-defined binding pockets at the large and flat PPI interfaces. Synthetic polymers offer an opportunity to circumvent these challenges by providing unparalleled flexibility in tuning their physiochemical properties to achieve… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Publication Types

Select...

Relationship

0
0

Authors

Journals

citations
Cited by 0 publications
references
References 243 publications
0
0
0
Order By: Relevance

No citations

Set email alert for when this publication receives citations?