Polymers in Matrix Type Transdermal Patch

Abstract

Transdermal drug delivery is the administration of therapeutic agents through intact skin for systemic effect. Polymers are the backbone of the matrix-type transdermal patches. Based on the nature of origin, these polymers can be Natural, Semi-synthetic, and Synthetic polymers. Several experimental results have revealed the fact that in the case of the fabrication of matrix-type patches, the use of a polymeric blend becomes more effective than the use of a single polymer to control the rate of drug release from the patch. In this context, the selection of an appropriate combination of polymers becomes very crucial to modulate the rate and extent of release of drugs from matrix-type patches. It is essential to have sound knowledge of the inherent properties of different polymers for the selection of an appropriate combination of polymers to achieve the controlled drug release from the matrix-type patches. This article assembles comprehensive up-to-date information on various categories of polymers and polymer blends being used for the development of matrix type patches, the inherent characteristics of these different categories of polymers, and their impact on physio-mechanical properties as well as the rate of drug release from drug-loaded patches.

Formulasi Dan Evaluasi Sediaan Transdermal Patch Ekstrak Kulit Buah Apel Manalagi (Malus Sylvestris L. Mill) dengan Kombinasi Polimer Hidroksi Propil Metil Selulosa dan Etil Selulosa

“…Penggunaan campuran polimer HPMC dan etil selulosa bertujuan agar menghasilkan sediaan transdermal patch yang lebih kuat dan fleksibel [9]. Selain itu, penggunaan campuran polimer lebih efektif daripada penggunaan polimer tunggal dalam mengontrol laju pelepasan obat dari patch [10]. Pembuatan transdermal patch dilakukan dengan cara polimer HPMC dan etil selulosa dicampurkan hingga homogen [11].…”

Formulation and Evaluation of Transdermal Patches Containing BGP-15

“…These patches are designed to be applied to the skin while delivering a therapeutically effective dose of one or more active ingredients into the systemic circulation through the layers of the skin [ 4 , 5 , 6 ]. The most basic and important components of transdermal patches are the polymers as they provide numerous functions such as forming the matrix, controlling the rate of drug delivery, providing protection, adhesion, flexibility and permeation [ 1 , 7 , 8 , 9 ].…”

“…These matrices can be formulated by the dispersion of an active pharmaceutical ingredient in a solid state or liquid polymer base [ 1 , 7 ]. An ideal polymer should meet some requirements such as proper stability and good compatibility with the chemical agent and the other elements that were used; moreover, they should contribute to a predictable drug release [ 10 ].…”