Polymers in oral insulin delivery

Sonia, Thundiparambil Azeez; Sharma, Chandra P.

doi:10.1533/9781908818683.257

Cited by 16 publications

(26 citation statements)

References 178 publications

(188 reference statements)

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“…The application of a biopolymer as a multiparticulate excipient for protein/peptide delivery has long been extensively recorded in the scientific literature [ 2 , 23 ]. This kind of matrix currently has great potential to be applied for the controlled release of drugs because of its relatively small molecular size.…”

Section: Resultsmentioning

confidence: 99%

“…This kind of matrix currently has great potential to be applied for the controlled release of drugs because of its relatively small molecular size. Furthermore, bioavailability and drug absorption could be improved as a result of a large surface area to volume level ratio, which leads to significantly more intimate contact along with the mucus layer [ 11 , 23 ].…”

Section: Resultsmentioning

confidence: 99%

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Insulin Inclusion into a Tragacanth Hydrogel: An Oral Delivery System for Insulin

Nur

Vasiljevic

2018

Materials

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Nanoparticles or microparticles created by physical complexation between two polyelectrolytes may have a prospective use as an excipient for oral insulin administration. Natural polymers such as tragacanth, alginate, dextran, pullulan, hyaluronic acid, gelatin and chitosan can be potential candidates for this purpose. In this research, insulin particles were prepared by the inclusion of insulin into a tragacanth hydrogel. The effect of the pH and concentration relationship involving polyelectrolytes offering individual particle size and zeta potential was assessed by zetasizer and scanning electron microscopy (SEM). Insulin–tragacanth interactions at varying pH (3.7, 4.3, 4.6, or 6), and concentration (0.1%, 0.5%, or 1% w/w) were evaluated by differential scanning calorimetry (DSC) and ATR Fourier transform infrared (ATR-FTIR) analysis. Individual and smaller particles, approximately 800 nm, were acquired at pH 4.6 with 0.5% of tragacanth. The acid gelation test indicated that insulin could be entrapped in the physical hydrogel of tragacanth. DSC thermograms of insulin–tragacanth showed shifts on the same unloaded tragacanth peaks and suggested polyelectrolyte–protein interactions at a pH close to 4.3–4.6. FTIR spectra of tragacanth–insulin complexes exhibited amide absorption bands featuring in the protein spectra and revealed the creation of a new chemical substance.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Insulin Inclusion into a Tragacanth Hydrogel: An Oral Delivery System for Insulin

Nur

Vasiljevic

2018

Materials

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“…6 And to give a single example of application, pMAA-based hydrogels may be used to protect hydrolysable drugs from acidic media and are reported among the most suitable synthetic polymers for oral insulin delivery. 7,8 Stimuli responsive systems, able to work in an organic solvent are less common but might be useful, for instance to design smart reaction media for organic synthesis. Early observations relate to phase separations occurring close to the critical point (i.e.…”

Section: Introductionmentioning

confidence: 99%

Polymethacrylic Acid Shows Thermoresponsivity in an Organic Solvent

et al. 2019

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The alternating sequenced copolymer poly-(methacrylic acid-alt-hydroxyethyl acrylate), p(MAA-alt-HEA), was recently found to display a lower critical solution temperature (LCST) behavior in 1,2-dimethoxyethane (DME), whereas the random copolymer of the same average molecular weight and composition did not. As an effort to understand this peculiar behavior, we investigated solutions of both corresponding homopolymers, poly(methacrylic acid) (pMAA) and poly(2-hydroxyethyl acrylate) (pHEA), in DME. We found that in the same temperature range, concentration, and degree of polymerization, pHEA is fully soluble, whereas pMAA shows the LCST behavior similar to the alternating copolymer. On the basis of Hansen’s parameters of the homopolymers, it would be predicted that neither should dissolve in DME. Solubility is therefore connected to specific solvent–polymer interactions and more specifically to the formation of a polymer–solvent complex via hydrogen bonds. We designed a method which combines mid-infrared (MIR) and near-infrared (NIR) spectroscopy in solution to study hydrogen bonding as a function of temperature (by MIR) with simultaneous monitoring of LCST (by NIR). In parallel, the global shape of polymer chains and aggregates was characterized by small-angle neutron scattering in deuterated DME. It is found that pMAA chains form aggregates upon increase of temperature through formation of cyclic H-bonded dicarboxylic dimers. As for pHEA, the solvent’s quality of DME slightly decreases with temperature, but aggregation is prevented by entropic repulsion of the flexible side chains. We thus concluded that nonoccurrence of LCST in the random copolymer is due to the presence of pHEA homoblocks that maintain constant solubility over the whole temperature range.

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“…While the materials discussed have exhibited some excellent properties, they have also exhibited deficiencies 19 such as the formation of acidic species which can provoke problems for long-term stability [13] as well as their 20 unsuitability to withstanding high temperatures. These polymers therefore lack the ability to best restore a 21 maxillofacial defect.…”

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confidence: 99%

“…To further confirm the formation of the monomers, 13 C NMR was performed to allow the identification of…”

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confidence: 99%

Comparative study of photoinitiators for the synthesis and 3D printing of a light-curable, degradable polymer for custom-fit hard tissue implants

et al. 2020

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Three-dimensional (3D) printing enhances the production of on-demand fabrication of patient-specific devices 27 as well as anatomically fitting implants with high complexity in a cost-effective manner. Additive systems that 28 employ vat photopolymerisation such as stereolithography (SLA) and digital light projection (DLP) are used 29 widely in the field of biomedical science and engineering. However, additive manufacturing methods can be 30 limited by the types of materials that can be used. In this study, we present an isosorbide-based formulation for a 31 polymer resin yielding a range of elastic moduli between 1.7-3 GN/mm 2 dependent on the photoinitiator system 32 used as well as the amount of calcium phosphate filler added. The monomer was prepared and enhanced for 3D-33 printing using an SLA technique that delivered stable and optimized 3D-printed models. The resin discussed could 34 potentially be used following major surgery for the correction of congenital defects, the removal of oral tumours 35 and the reconstruction of the head and neck region. The surgeon is usually limited with devices available to restore 36 both function and appearance and with the ever-increasing demand for low-priced and efficient facial implants, 37 there is an urgent need to advance new manufacturing approaches and implants with a higher osseointegration 38 performance. 39 40 42 and skin, as well as essential supporting structures such as blood vessels and nerves [1]. There are approximately 43 60,000 craniofacial reconstruction surgeries carried out each year in the UK alone [2]. These operations are needed 44 as a result of trauma, such as road traffic accidents, surgery to remove tumours or to correct congenital anomalies 45 in babies and children born with conditions such as cleft lip and palate. In some cases, the reconstructive surgery 46 is needed to correct functional issues, such as creating more space inside the skull to enable a person's brain to 47 grow or even to provide better protection for their eyes. Oral and maxillofacial surgery specialises in treating 48 many conditions and diseases in the head, neck, face and jaw region [3]. With the ever-growing demand for a 49 suitable material to restore both function and appearance for patients there have been developments taking place 50 in the field of dental materials to best suit the ideal selection criteria to satisfy the functionality, biocompatibility, 51 aesthetics, durability and ease of manipulation and contourability as a maxillofacial material. Due to excellent 52 osseointegration and osteogenesis properties, autologous bone grafts remain a gold standard technique for surgery 53 in this area [4]. However, the use of autologous bone grafts has disadvantages such as the risk of infection, risk 54 of rejection and multiple operations, which lead to postoperative pain and discomfort for patients. 55

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Polymers in oral insulin delivery

Cited by 16 publications

References 178 publications

Insulin Inclusion into a Tragacanth Hydrogel: An Oral Delivery System for Insulin

Insulin Inclusion into a Tragacanth Hydrogel: An Oral Delivery System for Insulin

Polymethacrylic Acid Shows Thermoresponsivity in an Organic Solvent

Comparative study of photoinitiators for the synthesis and 3D printing of a light-curable, degradable polymer for custom-fit hard tissue implants

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