Polymers with improved short term hemocompatibility obtained by radiation grafting of N-vinylpyrrolidone onto silicone rubber

Chapiró, A.; Foex-Millequant, M.; Jendrychowska-Bonamour, A.-M.; Lerke, Y.; Sadurní, Patricia; Domurado, Dominique

doi:10.1016/0146-5724(80)90163-6

Cited by 27 publications

(8 citation statements)

References 3 publications

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“…Grafting using ionizing radiation generates free radicals on the material surface, enabling initiation of polymerization. γ‐radiation‐induced grafting of NVP has been successfully applied to various substrates, including silicone rubber,66, 67 poly( L ‐lactide),68 poly(tetrafluoroethylene hexafluoropropylene vinylidene fluoride),69 polyethylene (PE),70 and PP 63. Liu et al63 reported the graft polymerization of NVP on a PP microfiltration membrane by UV photo‐assisted and γ‐ray induced graft polymerizations.…”

Section: Surface Modification Using Pvpmentioning

confidence: 99%

Poly(N‐vinylpyrrolidone)‐Modified Surfaces for Biomedical Applications

Liu

et al. 2012

Macromolecular Bioscience

182

121

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Poly(N-vinylpyrrolidone) (PVP), an important water soluble synthetic polymer, has many desirable properties including low toxicity, chemical stability, and good biocompatibility. Since PVP is hemocompatible and physiologically inactive, it has been used as a blood plasma substitute. Surface modification with PVP has been investigated extensively over the past few years as a means of preventing nonspecific protein adsorption. PVP may therefore be seen as a promising antifouling surface modifier comparable to poly(ethylene glycol) (PEG). In this review, various approaches for the design and preparation of PVP-modified surfaces are summarized and potential biomedical applications of these PVP-modified materials are indicated. Finally, some perspectives on future research on PVP for surface modification are discussed.

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Section: Surface Modification Using Pvpmentioning

confidence: 99%

Poly(N‐vinylpyrrolidone)‐Modified Surfaces for Biomedical Applications

Liu

et al. 2012

Macromolecular Bioscience

182

121

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“…The largest number of studies on applications of radiation‐induced graft polymerization for obtaining medical polymers was carried out by Hoffman and co‐workers 40. 42–45 The radiation‐induced grafting of hydrophilic polymer systems, such as N ‐vinyl pyrolidone (NVP), 2‐hydroxyethyl methacrylate (HEMA), acrylamide (AAm), acrylic acid (AAc), glycidyl methacrylate (GMA), ethyleneglycol dimethacrylate (EGDMA) and ethyl methacrylate (EMA) onto silicone rubber, was studied 46–53. The grafting techniques in these studies exploit both simultaneous irradiation and pre‐irradiation methods.…”

Section: Surface Modificationmentioning

confidence: 99%

Modification of polysiloxane polymers for biomedical applications: a review

Abbasi

Mirzadeh

Katbab

2001

Polymer International

463

316

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This paper reviews methods of modifying polydimethylsiloxane (PDMS) polymers to improve their properties for biomedical applications. The modi®cation methods are discussed under three different categories: bulk, surface and other modi®cation techniques. Surface modi®cation techniques include physical and chemical techniques to modify polymer surfaces. Bulk modi®cation techniques include blending, copolymerization, interpenetrating polymer networks (IPNs) and functionalization. The third category includes less common modi®cation techniques.

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“…Although many reports can be found in the literature dealing with silicone/hydrogel composites and hydrogel‐grafted silicones, 10–27 interpenetrating polymer network systems made from hydrogels and silicone rubber have received relatively little attention 28–31…”

Section: Introductionmentioning

confidence: 99%

Sequential interpenetrating polymer networks of poly(2‐hydroxyethyl methacrylate) and polydimethylsiloxane

Abbasi

Mirzadeh

Katbab

2002

J of Applied Polymer Sci

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ABSTRACT:The preparation of interpenetrating polymer networks (IPNs) from silicone rubber and hydrogel forming poly(2-hydroxyethyl methacrylate) (HEMA) were studied. The HEMA monomer was polymerized with simultaneous crosslink formation in the presence of the swollen silicone rubber. To minimize the required number of experiments, the Taguchi method of experimental design involving the factors of temperature, monomer concentration, initiator concentration, and crosslinker concentration was used. Upon removal of the swelling solvent, an IPN was obtained which absorbed water in the manner of a hydrogel but had mechanical properties superior to a hydrogel.

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Polymers with improved short term hemocompatibility obtained by radiation grafting of N-vinylpyrrolidone onto silicone rubber

Cited by 27 publications

References 3 publications

Poly(N‐vinylpyrrolidone)‐Modified Surfaces for Biomedical Applications

Poly(N‐vinylpyrrolidone)‐Modified Surfaces for Biomedical Applications

Modification of polysiloxane polymers for biomedical applications: a review

Sequential interpenetrating polymer networks of poly(2‐hydroxyethyl methacrylate) and polydimethylsiloxane

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