Polymers with platinum drugs and other macromolecular metal complexes for cancer treatment

Callari, Manuela; Aldrich‐Wright, Janice R.; Souza, Paul L. de; Stenzel, Martina H.

doi:10.1016/j.progpolymsci.2014.05.002

Cited by 105 publications

(73 citation statements)

References 130 publications

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“…A macromolecular formulation of cisplatin, termed lipoplatin, that appears to selectively accumulate in the tumor environment [3] is also progressing through clinical trials and could lead to more selective treatments with reduced side-effects [4]. Many other types of macromolecular systems are also under development [5].…”

Section: Page 6 Of 100mentioning

confidence: 99%

The development of RAPTA compounds for the treatment of tumors

Murray

Babak

Hartinger

et al. 2016

Coordination Chemistry Reviews

412

348

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Section: Page 6 Of 100mentioning

confidence: 99%

The development of RAPTA compounds for the treatment of tumors

Murray

Babak

Hartinger

et al. 2016

Coordination Chemistry Reviews

412

348

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“…However, the inclusion of TiCl 2 (O i Pr) 2 afforded isomer I with high diastereoselectivity (95% ds). Interestingly, other LAs, namely ZnBr 2 and Ti(O i Pr) 4 , afforded virtually no selectivity. The reaction solvent was also found to have a minor influence on stereoselectivity with dichloromethane (DCM) affording better control than acetonitrile or toluene.…”

Section: Lewis Acids In Radical-based Synthetic Transformationsmentioning

confidence: 99%

Mechanistic Perspectives on Stereocontrol in Lewis Acid-Mediated Radical Polymerization

Noble¹,

Coote²

2015

Advances in Physical Organic Chemistry

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“…The bestknown NPs include gold (Au), silver (Ag), platinum (Pt), zinc (Zn) and Titanium dioxide (TiO 2 particles etc. [52][53][54][55][56] They are effectively used for therapies in cancer and other diseases.…”

Section: Why Nanomedicinesmentioning

confidence: 99%

Normalizing Tumor Microenvironment Provide Unprecedented Opportunity for Improving Nanomedicine

Yi¹,

Rehman²,

Zhao³

et al. 2015

j bionanosci

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Cancer is one of the major causes of death all over the world. Currently, surgery, radiotherapy and chemotherapy are in vogue in cancer therapies. However, post-surgery complication, adverse effect of radiotherapy, and low efficacy with drug resistance in chemotherapy are still big challenges. Currently, as a new therapeutic strategy in cancer, nanomedicine has shown its potential, but several limitations caused by inefficient delivery hamper its development. Tumor microenvironment plays critical role in tumorigenesis, and its properties such as hypoxia, high interstitial fluid pressure (IFP) and low tumor blood flow (TBF) limit the delivery of nano-scale therapeutic agents. Nevertheless, a new theory suggests that tumor microenvironment could be normalized by anti-angiogenic drugs, and which eventually improves cancer therapeutic outcome. In this review, we focus on the promising prospects of nanomedicines in terms of normalizing tumor microenvironment.

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Polymers with platinum drugs and other macromolecular metal complexes for cancer treatment

Cited by 105 publications

References 130 publications

The development of RAPTA compounds for the treatment of tumors

The development of RAPTA compounds for the treatment of tumors

Mechanistic Perspectives on Stereocontrol in Lewis Acid-Mediated Radical Polymerization

Normalizing Tumor Microenvironment Provide Unprecedented Opportunity for Improving Nanomedicine

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