Polymersome Poration and Rupture Mediated by Plasmonic Nanoparticles in Response to Single-Pulse Irradiation

DiSalvo, Gina Marie; Robinson, Abby; Aly, Mohamed S; Hoglund, Eric R.; O’Malley, Sean M.; Griepenburg, Julianne C.

doi:10.3390/polym12102381

Cited by 7 publications

(4 citation statements)

References 28 publications

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“…This technique allows the determination of the size, lamellarity, and concentration of a dye and can distinguish free and incorporated dyes. Thus, polymersomes can be visualized under fluorescence microscopy by employing fluorophores such as Nile red (NR), among many others [ 185 , 188 , 189 ]. Finally, atomic force microscopy (AFM) is another microscopy method for assessing mechanical, electrical, and surface properties.…”

Section: Polymersomes As a Platform For Anticancer Therapeutic Deliverymentioning

confidence: 99%

“…Further, the plasmonic nanoparticles have been suggested as photothermal agents through the excitation of their LSPR. For example, DiSalvo et al developed micro and nano-polymersomes employing the diblock copolymer PBD 35 - b -PEO 20 through the gel-assisted rehydration method [ 189 ]. Polymersomes containing 2.5 nm hydrophobic dodecanethiol plasmonic AuNPs within the hydrophobic membrane promoted poration and/or rupture by a 532 nm wavelength pulsed laser.…”

Section: Light-responsive Polymersomes For Anticancer Therapeutic Del...mentioning

confidence: 99%

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Light-Triggered Polymersome-Based Anticancer Therapeutics Delivery

et al. 2022

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Polymersomes are biomimetic cell membrane-like model structures that are self-assembled stepwise from amphiphilic copolymers. These polymeric (nano)carriers have gained the scientific community’s attention due to their biocompatibility, versatility, and higher stability than liposomes. Their tunable properties, such as composition, size, shape, and surface functional groups, extend encapsulation possibilities to either hydrophilic or hydrophobic cargoes (or both) and their site-specific delivery. Besides, polymersomes can disassemble in response to different stimuli, including light, for controlling the “on-demand” release of cargo that may also respond to light as photosensitizers and plasmonic nanostructures. Thus, polymersomes can be spatiotemporally stimulated by light of a wide wavelength range, whose exogenous response may activate light-stimulable moieties, enhance the drug efficacy, decrease side effects, and, thus, be broadly employed in photoinduced therapy. This review describes current light-responsive polymersomes evaluated for anticancer therapy. It includes light-activable moieties’ features and polymersomes’ composition and release behavior, focusing on recent advances and applications in cancer therapy, current trends, and photosensitive polymersomes’ perspectives.

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Section: Polymersomes As a Platform For Anticancer Therapeutic Deliverymentioning

confidence: 99%

Section: Light-responsive Polymersomes For Anticancer Therapeutic Del...mentioning

confidence: 99%

Light-Triggered Polymersome-Based Anticancer Therapeutics Delivery

et al. 2022

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“…Additionally, as shown by Dong et al, AT-capped AuNPs can result in unexpected effects such as enhanced magnetization, which scales with chain length [14]. A leading benefit of AT functionality, however, still resides with the hydrophobicity it imparts to the AuNPs facilitating their suspension in apolar environments; for example, they can serve as photosensitizers in lipid and polymeric vesicles [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

The Influence of Alkanethiols on the Production of Hydrophobic Gold Nanoparticles via Pulsed Laser Ablation in Liquids

et al. 2021

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The ability to suspend plasmonic metal nanoparticles in apolar environments is an important feat towards harnessing their optical properties for use in amphiphilic biological environments. Pulsed laser Ablation in Liquids (PLAL) is a well-established method for the production of gold nanoparticles (AuNPs) in aqueous environments; however, ablation in organic liquids for the synthesis of hydrophobic AuNPs still has many unknowns, such as the relationship between colloidal stability and the ligand shell. In this study, hydrophobic AuNPs were produced by PLAL of gold in a 1-alkanethiol/n-decane solution and treated with laser fragmentation. Results demonstrate that longer chain length ATs produced particles with a smaller average size; however, there was no strong correlation between alkanethiol (AT) concentration and particle size. Stability was investigated by monitoring the temporal evolution of the extinction spectra which revealed that lower concentrations of AT stabilize the colloids while higher concentrations tend to result in quicker particle aggregation. Furthermore, longer chain length ATs demonstrated improved stability. Additionally, vibrational spectroscopy was employed to examine the AuNP surface chemistry, which pointed to the presence of oxidized carbon species and graphitic carbon.

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“…G. M. Di Salvo et al [ 19 ] studied the self-assembly of amphiphilic diblock copolymers into polymeric vesicles, commonly known as polymersomes, resulting in a versatile system for a variety of applications including drug delivery and microreactors. In this study, the incorporation of hydrophobic plasmonic nanoparticles within a polymersome membrane facilitated the light-stimulated release of vesicle encapsulants.…”

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confidence: 99%