Polymersomes from Amphiphilic Glycopolymers Containing Polymeric Liquid Crystal Grafts

Ferji, Khalid; Nouvel, Cécile; Babin, Jérôme; Li, Min-Hui; Gaillard, Cédric; Nicol, Erwan; Chassenieux, Christophe; Six, Jean‐Luc

doi:10.1021/acsmacrolett.5b00471

Cited by 29 publications

(13 citation statements)

References 43 publications

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“…A Z-average radius of gyration (R g ) equal to 111 nm was determined by analyzing the static light scattering data using the Guinier plot method. A so-called

-ratio (

= R g /R H ), which is an important indication of the morphology of scattering nanoparticles, close to 1 (

= 1.02) was obtained, suggesting the formation of vesicular morphology with the triblock [ 15 , 31 ]. These findings agreed well with the TEM image, where spherical hollow nanoobjects were clearly observed ( Figure 4 B and Figure S5 ).…”

Section: Resultsmentioning

confidence: 85%

“…1 H NMR (left) and31 P NMR (right) analyses of the thymidine-containing diblock copolymer (PBLG-b-PPLGNu) (top) and triblock copolymer (PPLGNu-b-PBLG-b-PPLGNu) (down). Solvent: D2O, 31 P NMR depicts a superposition of spectra of AZTP and the copolymer copolymer upon CuAAc grafting (drawings: PBLG in green, PPLG in blue and red dots for AZTP).…”

mentioning

confidence: 99%

“…to alkynes groups) was then added and the Schlenk tube was placed in an oil bath at 25 • C for 16 h. The crude product was purified by dialysis for 4-5 days against milliQ water (Spectra/Por MWCO 3.5 kDa membrane), containing EDTA the first 2 days and then the polymer was recovered upon centrifugation (yield 91%). 1 H NMR (400MHz, D 2 O, δ in ppm) CH thymidine AZTP), 8.52 (s broad, 49H, CH triazole) 31. P NMR (162MHz, D 2 O, δ in ppm): −0.06 ppm (broad).…”

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confidence: 99%

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Amphiphilic Nucleobase-Containing Polypeptide Copolymers—Synthesis and Self-Assembly

et al. 2020

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Nucleobase-containing polymers are an emerging class of building blocks for the self-assembly of nanoobjects with promising applications in nanomedicine and biology. Here we present a macromolecular engineering approach to design nucleobase-containing polypeptide polymers incorporating thymine that further self-assemble in nanomaterials. Diblock and triblock copolypeptide polymers were prepared using sequential ring-opening polymerization of γ-Benzyl-l-glutamate N-carboxyanhydride (BLG-NCA) and γ-Propargyl-l-glutamate N-carboxyanhydride (PLG-NCA), followed by an efficient copper(I)-catalyzed azide alkyne cycloaddition (CuAAc) functionalization with thymidine monophosphate. Resulting amphiphilic copolymers were able to spontaneously form nanoobjects in aqueous solutions avoiding a pre-solubilization step with an organic solvent. Upon self-assembly, light scattering measurements and transmission electron microscopy (TEM) revealed the impact of the architecture (diblock versus triblock) on the morphology of the resulted nanoassemblies. Interestingly, the nucleobase-containing nanoobjects displayed free thymine units in the shell that were found available for further DNA-binding.

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“…A Z-average radius of gyration (R g ) equal to 111 nm was determined by analyzing the static light scattering data using the Guinier plot method. A so-called

-ratio (

= R g /R H ), which is an important indication of the morphology of scattering nanoparticles, close to 1 (

Section: Resultsmentioning

confidence: 85%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Amphiphilic Nucleobase-Containing Polypeptide Copolymers—Synthesis and Self-Assembly

et al. 2020

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“…Polymersomes are some of the most efficient nanomaterials for use as drug delivery systems with a special surface functionalization ( Discher et al, 1999 ; Tuguntaev et al, 2016 ). They are artificial vesicles composed of amphiphilic block or grafted copolymers, and they emerged thanks to their high colloidal stability, strong membrane properties, as well as easy ligand conjugation with high biocompatibility ( Ferji et al, 2015 ; Ferji et al, 2018 ; Guan et al, 2015 ). Fig.…”

Section: Future Directions Based On Polymersomesmentioning

confidence: 99%

COVID-19 infection and nanomedicine applications for development of vaccines and therapeutics: An overview and future perspectives based on polymersomes

Al-Hatamleh

Hatmal

Alshaer

et al. 2021

European Journal of Pharmacology

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The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which emerged in December 2019 and caused the coronavirus disease 2019 (COVID-19) pandemic, took the world by surprise with an unprecedented public health emergency. Since this pandemic began, extraordinary efforts have been made by scientists to understand the pathogenesis of COVID-19, and to fight the infection by providing various preventive, diagnostic and treatment opportunities based on either novel hypotheses or past experiences. Despite all the achievements, COVID-19 continues to be an accelerating health threat with no specifically approved vaccine or therapy. This review highlights the recent advances in COVID-19 infection, with a particular emphasis is put on nanomedicine applications that can help to succeed in the development of effective vaccines or therapeutics against COVID-19. A novel future perspective has been proposed in this review based on utilizing polymersome nano-objects for effectively suppressing the cytokine storm, which may reduce the severity of COVID-19 infection.

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“…Enhanced delivery of drugs, preventing early degradation of the encapsulated drug, cost-effective formulations of expensive drugs and efficient treatment, improved performance features of the product, protection of the active drug from environmental factors, as well as reduced systemic toxicity. Weak mechanical properties of liposomes may be enhanced by using polymeric liposomes called polymersomes [47]. Possibility to encapsulate hydrophobic drugs in the lipidic bilayer, as well as hydrophilic drugs in the hydrophilic core [48].…”

Section: Liposomes and Polymersomes [30 Nm-110 Nm]mentioning

confidence: 99%

Synergistic Effects of Nanomedicine Targeting TNFR2 and DNA Demethylation Inhibitor—An Opportunity for Cancer Treatment

Al-Hatamleh

Boer

et al. 2019

Cells

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Tumor necrosis factor receptor 2 (TNFR2) is expressed on some tumor cells, such as myeloma, Hodgkin lymphoma, colon cancer and ovarian cancer, as well as immunosuppressive cells. There is increasingly evidence that TNFR2 expression in cancer microenvironment has significant implications in cancer progression, metastasis and immune evasion. Although nanomedicine has been extensively studied as a carrier of cancer immunotherapeutic agents, no study to date has investigated TNFR2-targeting nanomedicine in cancer treatment. From an epigenetic perspective, previous studies indicate that DNA demethylation might be responsible for high expressions of TNFR2 in cancer models. This perspective review discusses a novel therapeutic strategy based on nanomedicine that has the capacity to target TNFR2 along with inhibition of DNA demethylation. This approach may maximize the anti-cancer potential of nanomedicine-based immunotherapy and, consequently, markedly improve the outcomes of the management of patients with malignancy.Cells 2020, 9, 33 2 of 16 and tumor cells [6][7][8]. In contrast, TNFR2 expression was only reported on tumor cells and suppressive immune cells, suggesting that TNFR2 directly promotes cancer development [9]. Furthermore, the latest preclinical and clinical studies confirmed the implication of TNF-TNFR2 signaling in cancer proliferation and the suppression of immune response [10,11]. Consequently, blockade of TNF-TNFR2 axis could be a promising option for cancer treatment (Figure 1).On the other hand, nanotechnology provided several platforms in the field of immunotherapy and made significant advances towards safe and efficient targeting systems with positive clinical outcomes and minimal side effects; this is the so-called field of nanomedicine [12]. Despite the emerging trends of using nanoparticles in immunotherapy, no studies have investigated any type of nanocarriers to target TNFR2 on cancer cells. However, based on some previous novel reports about the effects of nanoparticles on immune homeostasis [13], especially using nanoparticles to promote TNFR2 + Foxp3 + regulatory T cells (Tregs) in inflammatory models [14,15], we have suggested in our recent perspective review the possibility of blocking TNF-TNFR2 axis via nanoparticles [16].

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Polymersomes from Amphiphilic Glycopolymers Containing Polymeric Liquid Crystal Grafts

Cited by 29 publications

References 43 publications

Amphiphilic Nucleobase-Containing Polypeptide Copolymers—Synthesis and Self-Assembly

Amphiphilic Nucleobase-Containing Polypeptide Copolymers—Synthesis and Self-Assembly

COVID-19 infection and nanomedicine applications for development of vaccines and therapeutics: An overview and future perspectives based on polymersomes

Synergistic Effects of Nanomedicine Targeting TNFR2 and DNA Demethylation Inhibitor—An Opportunity for Cancer Treatment

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