“…Due to the absence of hydrogen bonding and stereogenic centers along the backbone ( Figure 1 ), polypeptoids exhibit good thermal processability and solubility in various organic solvents, as well as enhanced protease stability, in sharp contrast to polypeptides. These features make polypeptoid a potential candidate for a wide variety of biomedical and biotechnological applications, such as antifouling coatings [ 46 , 47 , 48 , 49 , 50 , 51 ], drug/gene delivery [ 52 , 53 , 54 , 55 ] and biosensing [ 56 , 57 , 58 ]. Recent developments in the controlled polymerization and solid-phase synthesis have enabled access to a variety of polypeptoids with tailorable chain length, N-substituent structures, sequence, and architecture [ 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 ].…”