Polymethine‐Based Semiconducting Polymer Dots with Narrow‐Band Emission and Absorption/Emission Maxima at NIR‐II for Bioimaging

Liu, Ming‐Ho; Zhang, Zhe; Yang, Yea Ru; Chan, Yang Hsiang

doi:10.1002/ange.202011914

Cited by 9 publications

(6 citation statements)

References 65 publications

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“…Glass capillary tubes (OD = 1.5 mm/ID = 1.1 mm) filled with IR-TPE Pdots were immersed in the Intralipid ® solution. IR-TPE Pdots were synthesized according to the method in our previous study [ 22 , 23 ]. Capillaries were immersed at depths from 1 to 6 mm from the surface.…”

Section: Methodsmentioning

confidence: 99%

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Development of Stereo NIR-II Fluorescence Imaging System for 3D Tumor Vasculature in Small Animals

Lin

Chan

et al. 2022

Biosensors

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Near-infrared-II (NIR-II, 1000–1700 nm) fluorescence imaging boasts high spatial resolution and deep tissue penetration due to low light scattering, reduced photon absorption, and low tissue autofluorescence. NIR-II biological imaging is applied mainly in the noninvasive visualization of blood vessels and tumors in deep tissue. In the study, a stereo NIR-II fluorescence imaging system was developed for acquiring three-dimension (3D) images on tumor vasculature in real-time, on top of the development of fluorescent semiconducting polymer dots (IR-TPE Pdots) with ultra-bright NIR-II fluorescence (1000–1400 nm) and high stability to perform long-term fluorescence imaging. The NIR-II imaging system only consists of one InGaAs camera and a moving stage to simulate left-eye view and right-eye view for the construction of 3D in-depth blood vessel images. The system was validated with blood vessel phantom of tumor-bearing mice and was applied successfully in obtaining 3D blood vessel images with 0.6 mm- and 5 mm-depth resolution and 0.15 mm spatial resolution. The NIR-II stereo vision provides precise 3D information on the tumor microenvironment and blood vessel path.

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Section: Methodsmentioning

confidence: 99%

“…NIR-II imaging agents have been applied in optical angiography for visualizing blood vessel structure [ 16 , 17 , 18 , 19 , 20 , 21 ]. In our previous study, NIR-II fluorescent semiconducting polymer dots (IR-TPE Pdots) were developed to obtain high SNR NIR-II blood vessel imaging [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Development of Stereo NIR-II Fluorescence Imaging System for 3D Tumor Vasculature in Small Animals

Lin

Chan

et al. 2022

Biosensors

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“…To construct an ideal small molecular NIR-II fluorophore for high-performance phototheranostics, several main factors should be taken into consideration, including stability, fluorescence emission wavelength, brightness, photothermal conversion efficiency and ROS generation efficiency. 61 , 62 , 63 , 64 …”

Section: Design Principles and Common Cores For Small Molecular Nir-ii Fluorophoresmentioning

confidence: 99%

Small Molecular NIR-II Fluorophores for Cancer Phototheranostics

et al. 2021

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Summary Phototheranostics integrates deep-tissue imaging with phototherapy (containing photothermal therapy and photodynamic therapy), holding great promise in early diagnosis and precision treatment of cancers. Recently, second near-infrared (NIR-II) fluorescence imaging exhibits the merits of high accuracy and specificity, as well as real-time detection. Among the NIR-II fluorophores, organic small molecular fluorophores have shown superior properties in the biocompatibility, variable structure, and tunable emission wavelength than the inorganic NIR-II materials. What's more, some small molecular fluorophores also display excellent cytotoxicity when illuminated with the NIR laser. This review summarizes the progress of small molecular NIR-II fluorophores with different central cores for cancer phototheranostics in the past few years, focusing on the molecular structures and phototheranostic performances. Furthermore, challenges and prospects of future development toward clinical translation are discussed.

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“…Current fabrication of NIR‐II AFPs is mainly centered on NIR‐II fluorophores including rare earth‐doped nanoparticles (RENPs), [32–35] quantum dots (QDs), [26,36–39] single‐walled carbon nanotubes (SWNTs), [40–42] small molecule dyes, [16,43–46] conjugated polymers [47–50] and gold nanoclusters (AuNCs) [51–53] . In this section, the representative design and application of currently available NIR‐II fluorophores are introduced.…”

Section: Nir‐ii Materials (Fluorophores)mentioning

confidence: 99%

“…Lately, Yang et al. reported new conjugated‐polymethine‐dye polymers, which have narrow‐band, improved fluorescence quantum yield, NIR‐II absorption and emission [49] . This research provided a practicable approach to construct luminescent polymers with NIR‐IIa emission to avoid the inherent energy gap limitation for conjugated polymers.…”

Section: Nir‐ii Materials (Fluorophores)mentioning

confidence: 99%

Activatable NIR‐II Fluorescent Probes Applied in Biomedicine: Progress and Perspectives

et al. 2021

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With the advantage of inherent responsiveness that can change the spectroscopic signals from “off” to “on” state in responding to targets (e. g. biological analytes/microenvironmental factors), activatable fluorescent probes have attracted extensive attention and made significant progress in the field of bioimaging and biosensing. Due to the high depth of tissue penetration, minimal tissue damage and negligible background signal at longer wavelengths, the development of second near‐infrared window (NIR‐II) fluorescent materials provides a new opportunity to develop activable fluorescent probes. Here, we summarized properties, advantages and disadvantages of mainly NIR‐II fluorophores (such as rare earth‐doped nanoparticles, quantum dots, single‐walled carbon nanotubes, small molecule dyes, conjugated polymers and gold nanoclusters), then overviewed current role and development of activatable NIR‐II fluorescent probes (AFPs) for biomedical applications including biosensing, bioimaging and therapeutic. The potential challenges and perspectives of AFPs in deep‐tissue imaging and clinical application are also discussed.

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Polymethine‐Based Semiconducting Polymer Dots with Narrow‐Band Emission and Absorption/Emission Maxima at NIR‐II for Bioimaging

Cited by 9 publications

References 65 publications

Development of Stereo NIR-II Fluorescence Imaging System for 3D Tumor Vasculature in Small Animals

Development of Stereo NIR-II Fluorescence Imaging System for 3D Tumor Vasculature in Small Animals

Small Molecular NIR-II Fluorophores for Cancer Phototheranostics

Activatable NIR‐II Fluorescent Probes Applied in Biomedicine: Progress and Perspectives

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