Polymethyl methacrylate–ovalbumin @ graphene oxide drug carrier system for high anti-proliferative cancer drug delivery

Prabakaran, Selvakani; Jeyaraj, Murugaraj; Nagaraj, Ammavasi; Sadasivuni, Kishor Kumar; Rajan, Mariappan

doi:10.1007/s13204-019-00950-5

Cited by 42 publications

(28 citation statements)

References 44 publications

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“…Signal to noise (S/N) ratio factor was applied to deduce the optimum level of parameters. The S/N ratio was calculated by applying the 'larger the better' condition in the Equation (2).…”

Section: Drug Encapsulation and Optimization Using Taguchi Methodsmentioning

confidence: 99%

“…The major shortcoming is the nonselective nature of drug delivery resulting in damage to healthy normal tissues, causing severe adverse effects leading to a low life expectancy of cancer victims. 1,2 This condition probed intensive research toward the development of innovative biocompatible therapeutic agents, that can be effectively functionalized to achieve high drug encapsulation, stability, and cancer sitespecific delivery of the cytotoxic drugs. 3 The advances in nanotechnology in recent decades facilitated the development of multifunctional carrier materials, which can be suitably modified for specific biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

“…Despite the reasonable therapeutic effect offered by conventional treatment methods, the long‐term survival rate is still less. The major shortcoming is the nonselective nature of drug delivery resulting in damage to healthy normal tissues, causing severe adverse effects leading to a low life expectancy of cancer victims 1,2 . This condition probed intensive research toward the development of innovative biocompatible therapeutic agents, that can be effectively functionalized to achieve high drug encapsulation, stability, and cancer site‐specific delivery of the cytotoxic drugs 3 …”

Section: Introductionmentioning

confidence: 99%

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pH and magnetic field responsive protein‐inorganic nanohybrid conjugated with biotin: A biocompatible carrier system targeting lung cancer cells

Purushothaman

2020

J of Applied Polymer Sci

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Multi-stimuli responsive carrier systems, specifically targeting tumor cells are of high significance to improve the efficacy of cancer chemotherapy. In the present study, we have developed, characterized, and biologically evaluated magnetic casein-calcium ferrite hybrid biopolymeric carrier conjugated with biotin for targeted delivery of cinnamaldehyde to lung carcinoma. The dual stimuli-responsive carrier was successfully synthesized with small size, good stability, and high drug encapsulation efficiency. Natural drug cinnamaldehyde was encapsulated in the hybrid carrier, on which biotin was conjugated to facilitate selective cellular uptake. The prepared drug-carrier system exhibited pH-responsive drug release behavior with a higher release rate under acidic conditions, which can be effectively applied in targeted cancer chemotherapy. The superparamagnetic nature of calcium ferrite enabled magnetically-modulated drug delivery with faster drug release, reaching 85.5% within 4 h, in response to magnetic field stimulus. Kinetic modeling of drug release projected the diffusion-controlled release mechanism. Cell viability assay performed on L929 fibroblast and A549 lung cancer cells verified the biocompatibility and cytotoxicity of the developed formulation, respectively. The nanohybrid carrier significantly increased the anticancer potential of cinnamaldehyde with an 18-fold reduction in the IC 50 value, signifying the biotinfunctionalized protein-inorganic nanohybrid as an efficient multifunctional platform for targeted drug delivery.

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“…Signal to noise (S/N) ratio factor was applied to deduce the optimum level of parameters. The S/N ratio was calculated by applying the 'larger the better' condition in the Equation (2).…”

Section: Drug Encapsulation and Optimization Using Taguchi Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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pH and magnetic field responsive protein‐inorganic nanohybrid conjugated with biotin: A biocompatible carrier system targeting lung cancer cells

Purushothaman

2020

J of Applied Polymer Sci

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“…In one word, there is increasingly scientific evidences revealing the evil part of chemotherapy drugs in tumor treatment, including promotions of metastasis, proliferation, immune escape, and so on [1][2][3]. Therefore, to develop new treatment strategy including nanotechnology-based methodologies [4][5][6][7][8][9] for cancer has been under continuous investigation during the past a few years. One of the most highlighted progresses is the successful achievement of complete remission in clinical of B cell lymphoma after treated with chimeric antigen receptor (CAR) T cells [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Vγ9Vδ2 T Cells Strengthen Cisplatin Inhibition Activity Against Breast Cancer MDA-MB-231 Cells by Destructing Mitochondrial Function and Cell Ultrastructure

Huang

Wang

2020

Preprint

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Background: Breast cancer ranks second of new cases and fifth of death in 2018 world widely. Chemotherapy, one of cancer therapeutic strategies, plays important role in controlling mortality of breast cancer. Cis-platinum (CDDP), one of traditional chemotherapy drugs, had been used clinically for years. The crucial limitation of CDDP is due to its adverse effects on immune system. Development of new protocol that can minimize side effect and meanwhile elevate clinical efficacy of traditional drug like CDDP will eventually benefit cancer patients. Vγ9Vδ2 T cells had been reported to be able to up-regulate immune function of cancer patients, therefore, our hypothesis is that introduction of Vγ9Vδ2 T cells could potentiate CDDP efficacy against breast cancer. Methods: In the present work, breast cancer cell line MDA-MB-231 was used a model cell to test our hypothesis. The therapeutic dose of CDDP in vitro was analyzed by flow cytometry; The cytoskeleton was visualized by using a confocal microscopy, and the ultrastructure of the membrane was observed by atomic force microscopy to observe the effect of combined action on MDA-MB-231 cells; The mitochondrial function of MDA-MB-231 cells was detected, and the relevant mechanism of Vγ9Vδ2 T in enhancing cisplatin cells' inhibition of MDA-MB-231 cells was discussed. Results: Vγ9Vδ2 T cells could enhance CDDP-induced MDA-MB-231 cell membrane ultrastructure disorder and cytoskeleton disorder, and enhance the inhibition of CDDP on MDA-MB-231 cells, of which Vγ9Vδ2 T cells enhancing CDDP-induced mitochondrial dysfunction was one of its mechanisms. Conclusion: In this study，the mechanism of Vγ9Vδ2 T cells in enhancing the inhibition of cisplatin on MDA-MB-231 cells was studied, which could provide an important scientific clue for developing effective treatment schemes for breast cancer, especially the refractory TNBC breast cancer, based on Vγ9Vδ2 T cells in the future.

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“…The OVA-PMMA-GO-DOX system revealed successful loading and controllable release of the drug. 74 In a recent study, ultra-small SPIONs were grown on the GO nanosheets and finally were loaded by a modified form of DOX (CAD). The nano-sized theranostic agent proved a high antitumor effect and high-resolution MR imaging in-vivo.…”

mentioning

confidence: 99%

<p>Applications of Graphene and Graphene Oxide in Smart Drug/Gene Delivery: Is the World Still Flat?</p>

Hoseini‐Ghahfarokhi¹,

Mirkiani²,

Mozaffari³

et al. 2020

IJN

165

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Graphene, a wonder material, has made far-reaching developments in many different fields such as materials science, electronics, condensed physics, quantum physics, energy systems, etc. Since its discovery in 2004, extensive studies have been done for understanding its physical and chemical properties. Owing to its unique characteristics, it has rapidly became a potential candidate for nano-bio researchers to explore its usage in biomedical applications. In the last decade, remarkable efforts have been devoted to investigating the biomedical utilization of graphene and graphene-based materials, especially in smart drug and gene delivery as well as cancer therapy. Inspired by a great number of successful graphene-based materials integrations into the biomedical area, here we summarize the most recent developments made about graphene applications in biomedicine. In this paper, we review the up-to-date advances of graphene-based materials in drug delivery applications, specifically targeted drug/ gene delivery, delivery of antitumor drugs, controlled and stimuli-responsive drug release, photodynamic therapy applications and optical imaging and theranostics, as well as investigating the future trends and succeeding challenges in this topic to provide an outlook for future researches.

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Polymethyl methacrylate–ovalbumin @ graphene oxide drug carrier system for high anti-proliferative cancer drug delivery

Cited by 42 publications

References 44 publications

pH and magnetic field responsive protein‐inorganic nanohybrid conjugated with biotin: A biocompatible carrier system targeting lung cancer cells

pH and magnetic field responsive protein‐inorganic nanohybrid conjugated with biotin: A biocompatible carrier system targeting lung cancer cells

Vγ9Vδ2 T Cells Strengthen Cisplatin Inhibition Activity Against Breast Cancer MDA-MB-231 Cells by Destructing Mitochondrial Function and Cell Ultrastructure

<p>Applications of Graphene and Graphene Oxide in Smart Drug/Gene Delivery: Is the World Still Flat?</p>

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