Polymicrobial Versus Monomicrobial Keratitis

Lim, N.C.; Lim, Dawn Ka; Ray, Manotosh

doi:10.1097/icl.0b013e3182a3024e

Cited by 54 publications

(47 citation statements)

References 20 publications

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“…Multispecies biofilm-like communities are responsible for causing persistent infections in a wide range of body sites, including the lung (24)(25)(26)(27)(28)(29)(30)(31), oral cavity (32,33), middle ear (34)(35)(36), urinary tract (37)(38)(39), and both surgical and chronic wounds (40)(41)(42)(43)(44)(45). In several disease settings, polymicrobial infections have been reported to cause worse outcomes than single-species infections (46)(47)(48)(49)(50)(51)(52)(53)(54). In particular, polymicrobial bloodstream infections are associated with higher rates of mortality than monospecies infections (46)(47)(48)(49)(50).…”

Section: The Etiology Of Most Chronic Infections Is Polymicrobialmentioning

confidence: 99%

“It Takes a Village”: Mechanisms Underlying Antimicrobial Recalcitrance of Polymicrobial Biofilms

2019

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Chronic infections are frequently caused by polymicrobial biofilms. Importantly, these infections are often difficult to treat effectively in part due to the recalcitrance of biofilms to antimicrobial therapy. Emerging evidence suggests that polymicrobial interactions can lead to dramatic and unexpected changes in the ability of antibiotics to eradicate biofilms and often result in decreased antimicrobial efficacy in vitro.

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Section: The Etiology Of Most Chronic Infections Is Polymicrobialmentioning

confidence: 99%

“It Takes a Village”: Mechanisms Underlying Antimicrobial Recalcitrance of Polymicrobial Biofilms

2019

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“…These bacteria may spread via hand-to-eye contact or through colonization from adjacent tissues such as the nasal or sinus mucosa. Advances in diagnostics have led to a growing recognition of the polymicrobial nature of many infections [5][6][7][8][9], including topical ocular infections [10][11][12][13][14]. Moreover, research suggests that interactions between multiple bacterial species including commensal bacteria or other microbes (eg, viruses, fungi) may impact disease progression and treatment success.…”

Section: Introductionmentioning

confidence: 99%

“…For instance, studies of polymicrobial infections have documented alterations in virulence factors, biofilm formation, and antibiotic resistance or tolerance [5]. While much research has focused on the pathogenesis of the polymicrobial nature of systemic infections, research on polymicrobial infections of the eye has been limited to studies reporting on the frequency of such infections in keratitis and/or endophthalmitis, with rates ranging from 2-50% [10,11,14,[15][16][17][18][19][20][21][22][23], or as high as 83% for endophthalmitis using polymerase chain reaction amplification techniques [24].…”

Section: Introductionmentioning

confidence: 99%

Characterization of baseline polybacterial versus monobacterial infections in three randomized controlled bacterial conjunctivitis trials and microbial outcomes with besifloxacin ophthalmic suspension 0.6%

DeCory¹,

Sanfilippo²,

Proskin³

et al. 2020

PLoS ONE

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“…Além disso, nos últimos anos o número de infecções hospitalares e adquiridas na comunidade causadas por S. aureus resulta em aproximadamente 50.000 mortes a cada ano apenas nos EUA 11 . Diversos estudos já relataram o co-isolamento de ambas as espécies citadas em doenças como a periodontite, estomatite e cerite 13,14 .…”

Section: Introductionunclassified

Nanopartículas de prata biossintetizadas por Mikania glomerata Sprengel inibem o crescimento de Candida albicans e Staphylococcus aureus

Kischkel¹,

Yamanaka²,

Depieri³

et al. 2018

ACS

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Introduction:In recent years there has been an increase in cases related to infection by Candida spp. and Staphylococcus spp., as well as the appearance of strains resistant to conventional antibiotics. Nanoparticle biosynthesis consists of the reduction of a metal ion by compounds of natural origin as secondary metabolites of plants and organisms, being the most indicated form because it presents less toxicity when compared to the chemical synthesis. In this way, the biological synthesis is an alternative to obtain new active agents for the treatment of microbial infections. Objective: Synthesize silver nanoparticles from the aqueous extract of Mikania glomerata Sprengel and evaluate possible microbicidal and cytotoxic activity. Material and Methods: For the synthesis of the silver nanoparticles (AgNPs) an aqueous extract of the leaves of Mikania glomerata plus a solution of silver nitrate was used. AgNPs synthesized was evaluated by UV-vis spectrophotometer and FAAS. Furthermore, antimicrobial activity was evaluated against strains of Candida albicans and Staphylococcus aureus and cytotoxicity activity against HeLa and Vero cell lines. Results: AgNPs are shown to be more efficient in combating Candida albicans and Staphylococcus aureus strains when compared to the pure administered extract. Up to the concentration of 100 mg/mL of the pure aqueous extract no inhibitory effect was observed on both microorganisms. However when the strains were in contact with AgNPs, the inhibitory concentration was 0.006 mg/mL and 0.1 mg/mL for S. aureus and C. albicans, respectively. The cytotoxic effect on the cells behaves in a dose-dependent manner, presenting greater cytotoxic potential against the HeLa cancer cell line. Conclusion: Thus, these results are promising and contribute to research related to the production of drugs using plant extract and metals. The AgNPs synthesized presented the antimicrobial potential against C. albicans and S. aureus, in addition to low activity against normal cells, indicating their reliability for application of AgNPs as an alternative form of treatment.Contribuição dos autores: BK coleta, delineamento do estudo, elaboração do manuscrito e redação do manuscrito, AHUY coleta, delineamento do estudo, elaboração do manuscrito e redação do manuscrito, NBD coleta, delineamento do estudo, elaboração do manuscrito e redação do manuscrito, MN orientação do projeto, discussão dos achados, delineamento do estudo, elaboração do manuscrito.

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Polymicrobial Versus Monomicrobial Keratitis

Cited by 54 publications

References 20 publications

“It Takes a Village”: Mechanisms Underlying Antimicrobial Recalcitrance of Polymicrobial Biofilms

“It Takes a Village”: Mechanisms Underlying Antimicrobial Recalcitrance of Polymicrobial Biofilms

Characterization of baseline polybacterial versus monobacterial infections in three randomized controlled bacterial conjunctivitis trials and microbial outcomes with besifloxacin ophthalmic suspension 0.6%

Nanopartículas de prata biossintetizadas por Mikania glomerata Sprengel inibem o crescimento de Candida albicans e Staphylococcus aureus

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