Polymorph Control of <i>L</i>‐Phenylalanine in Cooling Crystallization by Ultrasonication

Ike, Yuki; Hirasawa, Izumi

doi:10.1002/ceat.201700662

Cited by 14 publications

(6 citation statements)

References 16 publications

(22 reference statements)

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“…The creation of agglomerates with smooth surfaces was observed during the sonication of Sn, Zn, Cu, Ni, Fe, and Cr slurries [7,24]. Ultrasound has also the potential to produce crystals with a different polymorphic form compared to silent conditions [99][100][101][102][103][104][105]. This change in polymorphic form is, however, not observed in all papers in literature which investigated the effect of ultrasound on polymorphism [91,106,107].…”

Section: Effects Of Ultrasound On Particle Shapementioning

confidence: 99%

Sonocrystallisation: Observations, theories and guidelines

Jordens

Gielen

Xiouras

et al. 2019

Chemical Engineering and Processing - Process Intensification

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Crystallization is an important and widely used separation technique in the chemical and pharmaceutical industry. Control of the final particle properties is of great importance for these industries. The application of ultrasound in these crystallization processes, also referred to as sonocrystallization, has shown to impact nucleation, crystal growth and fragmentation. As a result this technology has potential to control the final particle size, shape and polymorphic form.This review provides a comprehensive overview of the recent advances in sonocrystallization. It reviews the observed effects of ultrasound on the different stages of the crystallization process. Recent insights in the mechanism behind these effects are discussed as well. Finally, guidelines for the operating conditions, such as ultrasonic frequency, power, type of cavitation bubbles, time window and moment of application are formulated.

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Section: Effects Of Ultrasound On Particle Shapementioning

confidence: 99%

Sonocrystallisation: Observations, theories and guidelines

Jordens

Gielen

Xiouras

et al. 2019

Chemical Engineering and Processing - Process Intensification

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“…However up to now, no studies have been conducted on ultrasound-enhanced PX crystallization process, and the exploration of PX crystallization thermodynamics and nucleation mechanism is also not in-depth. The mechanism of ultrasound enhancement has not yet reached a consensus. − Many studies in the literature have only analyzed the apparent effect of ultrasonic on crystallization without detailed analysis of its mechanism. − These cause difficulties for ultrasonic-enhanced PX crystallization technology development.…”

Section: Introductionmentioning

confidence: 99%

Experimental Investigation of p-Xylene Crystallization Characteristics and Ultrasound Enhancement Mechanism

Dong

Wang

et al. 2022

Ind. Eng. Chem. Res.

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Para-xylene (PX) is one of the most crucial aromatic raw materials in petrochemical industry. It is urgent to develop a more low-cost and efficient PX production process due to the growing demand for PX. This paper introduces ultrasound into the PX crystallization process and analyzes the data of supersolubility, metastable zone width, and induction period of PX under different working conditions. Based on the classical nucleation theory and the cluster coalescence model, the PX crystallization characteristics and the mechanism of ultrasound enhancement are investigated. The results can be concluded as follows. Ultrasound significantly reduces the metastable zone width and induction period of the PX crystallization process, speeds up the crystal nucleation rate, and prevents the explosion nucleation. When the supersaturation is above 1.055, the PX nucleation mechanism is homogeneous nucleation, and when it is below 1.055, the PX nucleation mechanism is heterogeneous nucleation. The crystal growth mechanism is continuous growth. The PX-dominated cluster at the mesoscale contains 14 monomers. The formation period of clusters is accelerated by ultrasound, and the critical nucleation radius and critical nucleation free energy of PX are both dramatically decreased. The system's diffusion coefficient is improved by ultrasound, which also lowers the interfacial tension and the surface entropy factor corresponding to the two nucleation mechanisms. When the ultrasonic power changes from 0 to 88 W, the crystal nucleation rate constant increases by 22.4 times and the diffusion coefficient by 11.86 times. Theoretically, this study might enable future PX crystallization process improvements.

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“…12 Among these, sonocrystallization is being widely applied and proved to be a promising tool for the separation of polymorphs as an effective means of nucleation control. 13,14 Sonocrystallization is a process that involves the use of ultrasound to obtain high-value products with desirable characteristics.…”

Section: Introductionmentioning

confidence: 99%