Polymorphic Alu insertions in human populations of Bosnia and Herzegovina

Pojskić, Naris; Silajdžić, Elma; Kalamujić, Belma; Kapur-Pojskić, Lejla; Lasić, Lejla; Tulic, Una; Hadziselimovic, Rifat

doi:10.3109/03014460.2012.756063

Cited by 8 publications

(2 citation statements)

References 24 publications

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“…The allele frequencies of the sample analysed in this study are concordant with the general allele ratio found in other European populations included in ALFRED database (Rajeevan et al, 2003). This implies European character of the population of Bosnia and Herzegovina and reaffirms the findings of previous studies of B&H population which were based on different marker systems (Marjanović et al, 2005;Pojskić et al, 2013;Kovačević et al, 2014;Kapur-Pojskić et al, 2014). ADH1B RsaI population frequencies listed in ALFRED database (Rajeevan et al, 2003) show that European populations have conservative allele frequencies in favour of the ancestral variant (>0.69).…”

Section: Resultssupporting

confidence: 91%

Frequency of Adh1b Rsai (Rs2066701) Single Nucleotide Polymorphism in a Population of Bosnia and Herzegovina

Pecikoza¹,

Lasić²,

Radosavljevic³

et al. 2018

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Apart from its physiological role in the cellular oxidation of ethanol interesting feature of the ADH1B gene locus is its characteristic geographical distribution in which certain variants of ADH1B peak in different parts of the world. Therefore, ADH1B rs2066701 polymorphism is exploited as a genetic marker in tracing of the evolutionary processes and human migrations in the past. Taking into consideration the complexity of population genetic structure and several migrations in the history of the Balkan populations, including Bosnian and Herzegovinian, this study aimed to estimate the frequency of ADH1B rs2066701 polymorphism in the population of Bosnia and Herzegovina. The total of 101 randomly sampled individuals was genotyped for rs2066701 polymorphism in ADH1B gene using PCR-RFLP method. The obtained frequencies were used to calculate heterozygosity, fixation indices and Hardy-Weinberg equilibrium. Observed population-structure parameters were compared with other population values available in ALFRED database. Dimensional relations between the investigated populations were visualised with the NM-MDS (non metric multidimensional scaling) analysis using PAST. The minor allele frequency for rs2066701 was 0,257. Inter-population analysis including other European and non-European populations from the ALFRED database proved the above-mentioned European genetic background of the B&H population.

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Section: Resultssupporting

confidence: 91%

Frequency of Adh1b Rsai (Rs2066701) Single Nucleotide Polymorphism in a Population of Bosnia and Herzegovina

Pecikoza¹,

Lasić²,

Radosavljevic³

et al. 2018

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“…Bioanthropological research in Bosnia and Herzegovina began during the Austro-Hungarian Empire in the late 19th century, and the history of such research is presented in Lasic et al 2016. A number of bioanthropological and genetic studies have been performed in Bosnia and Herzegovina to assess the heterogeneity of local populations as well as the general B&H population (Berberovic 1969;Dogan et al 2016;Hadziselimovic 1981;Kapur-Pojskic et al 2014;Kovacevic et al 2013Kovacevic et al , 2014Lasic et al 2013Lasic et al , 2016Lasic et al , 2020Marjanovic et al 2005Marjanovic et al , 2005aMarjanovic et al , 2006Marjanovic et al , 2008Pojskic et al 2013). However, most of these works are based on molecular genetic markers, and a smaller part on phenotypic markers.…”

Section: Introductionmentioning

confidence: 99%

Phenotypic association of seven observed traits of hand complex

Kalajdžić

Pojskić

Čorbo

et al. 2021

J. bioanthropol. (Online)

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This paper provides an overview of the seven possible hand-related traits, with an idea to estimate the statistical phenotypic association between them. The traits observed in this study were: midphalangeal hair, Hitchhiker’s thumb, extensibility of proximal joint of thumb, digital index, nail shape, crooked fifth finger and hand clasping. The mentioned characteristics were observed in 7431 unrelated subjects, with approximately equal gender distribution. For each case, three groups were formed: total, male and female. The subjects were evenly distributed throughout Bosnia and Herzegovina’s various geographical regions, and they properly represent the country’s national and ethnic composition. The Chi-squared test was used to determine the statistical significance of the association between these traits, while Fisher’s exact test was utilized as an extra test to analyze the association between each pair of observed features. Also, Chi-squared test was applied for observing differences in the frequencies of the phenotypic characteristics of the hand between the genders. Following traits were shown to have a statistically significant association: midphalangeal hair-Hitchhiker’s thumb, midphalangeal hair – digital index, midphalangeal hair – nail shape, midphalangeal hair – crooked fifth finger, Hitchhiker’s thumb- extensibility of proximal joint of thumb, digital index – nail shape, digital index -crooked fifth finger, midphalangeal hair – hand clasping, crooked fifth finger – hand clasping. Analysis of differences in the frequencies of the observed phenotypic traits of the hand according to the genders showed statistical significance for D, Dht, Ref and Lf.

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