Polymorphic differences in the SOD-2 gene may affect the pathogenesis of nephropathy in patients with diabetes and diabetic complications

Pro198Leu Polymorphism in the Glutathione Peroxidase 1 Gene Contributes to Diabetic Peripheral Neuropathy in Type 2 Diabetes Patients

“…The single-nucleotide polymorphisms in genes coding for antioxidant enzymes may be associated with decreased or impaired ROS detoxification and increase oxidative damage (Flekac et al 2008). Molecular variants of antioxidant enzymes are potential risk factors for chronic complications of diabetes (Forsberg et al 2001; Houldsworth et al 2015). …”

A Review of the Role of Mitochondrial Manganese Superoxide Dismutase in Human Disorders, such as, Diabetes

“…A significant difference in the C-9-T genotype was observed between patients and normal controls but not between diabetic controls and patients with complications. In a study to ascertain if specific Genotypes have any protective influences in the pathogenic mechanisms in diabetes and/or in several different complications, there were significantly more of the diabetic controls than the patients with diabetic nephropathy the 'c allele' appeared to be protective against diabetic nephropathy [37].…”

Therapeutic Insights against Oxidative Stress Induced Diabetic Nephropathy: A Review

“…It is necessary to timely scavenge these free radicals otherwise persistent exposure to them can lead to tissue degradation directing its way to a state of organ pathophysiology. To prevent the deleterious effects of free radicals, the effects of antioxidants are extensively studied [83][84][85][86]. Antioxidants act through different mechanisms at various sites exerting a number of biochemical effects.…”