Polymorphic light eruption sine eruptione: A variant of polymorphous light eruption

Vellaichamy, Gautham; Chadha, Angad; Hamzavi, Iltefat; Lim, Henry W.

doi:10.1111/phpp.12565

Cited by 6 publications

(4 citation statements)

References 11 publications

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“…Finally, for the differential diagnosis, we can also consider a rare variant of polymorphic light eruption, termed polymorphic light eruption sine eruptione (PLESE) that was described in 7 patients in 1988 ( 26 ) and in another patient in 2020 ( 27 ). They experienced sun-induced pruritus and/or intense burning without evidence of cutaneous eruption ( 26 , 27 ). Unlike the current patients, low-dose broadband UVB phototherapy or PUVA photochemotherapy were always successful in reducing symptoms during subsequent summers.…”

Section: Discussionmentioning

confidence: 99%

Sunlight-induced Painful Skin (Sun Pain): A New Differential Diagnosis in Photodermatology

Calzavara‐Pinton

Venturini²,

Rovati³

et al. 2021

Acta Derm Venereol

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Photodermatoses are characterized by the development of skin eruptions following exposure to ultraviolet radiation or visible light. We report here the clinical findings and results of laboratory investigations and phototesting of 6 patients who experience debilitating and excruciating pain after sun exposure (“sun pain”) in the absence of any skin eruption. Phototesting with sub-erythemal doses of ultraviolet A radiation triggered localized pain in 4 patients. At follow-up, 3 female patients were found to have developed fibromyalgia, 2 male patients experienced a major depressive disorder, and another male patient had a conversion disorder. One patient also developed allodynia to tactile stimuli and one developed allodynia to thermal and tactile stimuli. Psychiatric conditions should be taken into consideration in patients presenting with excruciating and debilitating pain on exposure to ultraviolet radiation, but with absence of skin eruption. Further research is needed to evaluate whether it represents a type of allodynia triggered by exposure to ultraviolet radiation.

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Section: Discussionmentioning

confidence: 99%

Sunlight-induced Painful Skin (Sun Pain): A New Differential Diagnosis in Photodermatology

Calzavara‐Pinton

Venturini²,

Rovati³

et al. 2021

Acta Derm Venereol

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“…PLE sine eruption is characterised mainly by pruritus. Induced by the sun, it has chronic nature, however, visible eruption does not appear (2) . Another variant, erythema multiforme-like PMLE, is characterised by erythematous, oedematous skin lesions resembling iris lesions (9) .…”

Section: Types Of Pmlementioning

confidence: 99%

“…C lassified as an immune-mediated photodermatosis, polymorphous light eruption (PMLE) is the most common photodermatosis mainly in children and adolescents (1)(2)(3) . It is characterised by pruritic or tingling erythematous papular, vesiculopapular, or plaque lesions of sunlight-exposed skin occurring in spring or early summer (2,4) . Although the disease has been reported in all races, it is most likely to affect fair-skinned patients with Fitzpatrick skin type I.…”

Section: Introductionmentioning

confidence: 99%

Polymorphous light eruption in children – clinical presentation, differential diagnosis and treatment

Sankowska¹,

Janicka²,

Misiak-Gałązka³

et al. 2022

Pediatr Med Rodz

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Polymorphous light eruption is classified as an immune-mediated photodermatosis. It is the most common cause of photosensitivity in children between 6 and 14 years old. It is characterised by pruritic or tingling erythematous papular or plaque lesions of sunlight-exposed skin which occur in spring or early summer. The first signs of polymorphous light eruption typically appear several hours to days after the first exposure to intense sunlight and take the form of an irritable rash persisting for a few days, and subsiding within a week or two with minimal or no scarring. Its recurrences may have a detrimental impact on the quality of life. Due to the significant heterogeneity of clinical manifestations of polymorphous light eruption, the disorder is relatively challenging to diagnose. The differential diagnoses include photosensitivity associated with lupus erythematosus, solar urticaria, actinic prurigo, erythema multiforme, photocontact allergic dermatitis, and genetic dermatoses. UVA and UVB phototesting followed by histological examination is an important diagnostic tool to objectify light-related symptoms. Once the diagnosis is established, the patient should be monitored and educated on prevention. The management of polymorphous light eruption is based on prevention such as sun protection and sunscreens. The first-line treatment includes glucocorticoids and antihistamines.

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“…It has morphological variants, such as juvenile spring eruption, which mainly affects boys in the form of vesicles located on the pinnae ( 1 ). Polymorphous light eruption, which can manifest as a pinhead papular eruption on the face, has been described in patients with phototypes V-VI ( 2 ), as well as in forms of PLE without skin eruptions ( 3 ). Molina-Ruiz et al ( 4 ) reported a relapsing eruption of the elbows, with histopathological and immunohistochemical findings of PLE.…”

Section: Introductionmentioning

confidence: 99%

Summer and spring elbow rashes is a variant of polymorphous light eruption: confirmation by photoprovocation and histopathology in a series of five cases

de Gálvez,

Castillo-Muñoz,

López-Navarro

et al. 2023

Front. Med.

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BackgroundSummer and spring eruptions on the elbows are a variant of polymorphous light eruption described on clinical and histopathological grounds; however, to our knowledge, they have not been confirmed by photobiological studies.ObjectiveBased on photobiological studies, this study aimed to demonstrate the involvement of ultraviolet-A (UVA) radiation in this variant of polymorphous light eruption occurring exclusively on the elbows.MethodsA series of five patients with polymorphous light eruption lesions on the elbows were included in our study. All patients underwent phototesting and photoprovocation of the skin lesions after exposure to a UVA light source [Philips UVA HPA lamp (400 W)]. All patients underwent punch biopsy and histopathological and immunohistochemical studies with anti-CD123.ResultsIn all the cases, UVA irradiation caused the appearance of skin lesions on the elbows with characteristic polymorphous light eruption. Histological data showed edema in the superficial dermis and a perivascular lymphocytic infiltrate compatible with polymorphous light eruption. Immunohistochemical staining for CD1-23 showed negative results.ConclusionsFor the first time, photobiological photoprovocation studies demonstrated that repeated exposure to UVA radiation leads to the generation of skin lesions on the elbows, which are clinically and histologically consistent with summer and spring eruptions, confirming that elbow rash is a variant of polymorphous light eruption.

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Polymorphic light eruption sine eruptione: A variant of polymorphous light eruption

Cited by 6 publications

References 11 publications

Sunlight-induced Painful Skin (Sun Pain): A New Differential Diagnosis in Photodermatology

Sunlight-induced Painful Skin (Sun Pain): A New Differential Diagnosis in Photodermatology

Polymorphous light eruption in children – clinical presentation, differential diagnosis and treatment

Summer and spring elbow rashes is a variant of polymorphous light eruption: confirmation by photoprovocation and histopathology in a series of five cases

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