Polymorphic modifications of phenasal and their IR spectra

Kosheleva, L. I.; Bekhli, A. F.

doi:10.1007/bf00760697

Cited by 2 publications

(2 citation statements)

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“…Previous experimental studies on the crystal structure of niclosamide have reported two different results on conformational stability. Kosheleva et al 43 crystalized niclosamide and observed two conformations, the α and β-conformation, and noted that the latter conformation was thermolabile and easily transformed to the stable α-conformation. Later on, Caira et al 8 crystalized niclosamide in different solvent and only observed the β-conformation.…”

Section: Resultsmentioning

confidence: 99%

Cation–π interactions drive hydrophobic self-assembly and aggregation of niclosamide in water

et al. 2021

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Section: Resultsmentioning

confidence: 99%

Cation–π interactions drive hydrophobic self-assembly and aggregation of niclosamide in water

et al. 2021

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“…The solvates of niclosamide can also be distinguished from the anhydrate by the appearance of new stretching or bending frequencies resulting from solvation. In addition, according to Kosheleva and Bekhli 17 and Kosheleva et al, 18 niclosamide can exist in a trans (β-) and cis (α-) form, referring to 2 different conformations and intramolecular hydrogen bonding arrangements. The β-form predominates in 1,4-dioxane solutions.…”

Section: X-ray Powder Diffraction and Spectral Properties Of The Solvmentioning

confidence: 99%

Preparation and physicochemical characterization of 5 niclosamide solvates and 1 hemisolvate

Tonder¹,

Mahlatji²,

Malan³

et al. 2004

AAPS PharmSciTech

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INTRODUCTIONThe purpose of the study was to characterize the physicochemical, structural, and spectral properties of the 1:1 niclosamide and methanol, diethyl ether, dimethyl sulfoxide, N,N' dimethylformamide, and tetrahydrofuran solvates and the 2:1 niclosamide and tetraethylene glycol hemisolvate prepared by recrystallization from these organic solvents. Structural, spectral, and thermal analysis results confirmed the presence of the solvents and differences in the structural properties of these solvates. In addition, differences in the activation energy of desolvation, batch solution calorimetry, and the aqueous solubility at 25°C, 24 hours, showed the stability of the solvates to be in the order: anhydrate > diethyl ether solvate > tetraethylene glycol hemisolvate > methanol solvate > dimethyl sulfoxide solvate > N,N' dimethylformamide solvate. The intrinsic and powder dissolution rates of the solvates were in the order: anhydrate > diethyl ether solvate > tetraethylene glycol hemisolvate > N,N' dimethylformamide solvate > methanol solvate > dimethyl sulfoxide solvate. Although these nonaqueous solvates had higher solubility and dissolution rates than the monohydrous forms, they were unstable in aqueous media and rapidly transformed to one of the monohydrous forms.

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Polymorphic modifications of phenasal and their IR spectra

Cited by 2 publications

References 1 publication

Cation–π interactions drive hydrophobic self-assembly and aggregation of niclosamide in water

Cation–π interactions drive hydrophobic self-assembly and aggregation of niclosamide in water

Preparation and physicochemical characterization of 5 niclosamide solvates and 1 hemisolvate

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