Polymorphic Variants of Neurotransmitter Receptor Genes May Affect Sexual Function in Aging Males: Data from the HALS Study

Jóźków, Paweł; Słowińska-Lisowska, Małgorzata; Łaczmański, Łukasz; Mędraś, M

doi:10.1159/000350324

Cited by 2 publications

(2 citation statements)

References 30 publications

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“…Burt and Mikolajewski not only confirmed these findings with the DAT1 gene but extended these findings to include the His452Tyr variant of the gene encoding the 5-HT2A receptor as well [ 62 ]. More recently, Jóźków, et al reported an association between the sexual dimension of aging males' symptoms (AMS) and genetic variants of 5-HTR1B G861C [ 63 ]. Moreover, Sales, et al found through multivariable logistic regression analysis, an interaction between abuse and the 5-HTTLPR group was significantly associated with non-change status, along with partner communication frequency scores at follow-up [ 64 ].…”

Section: Reviewmentioning

confidence: 99%

Hypersexuality Addiction and Withdrawal: Phenomenology, Neurogenetics and Epigenetics.

Blum¹,

Badgaiyan²,

Gold³

2015

Cureus

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Hypersexuality is now part of the DSM-V and has been defined as abnormally increased sexual activity. Epidemiological and clinical studies have shown that this non-paraphilic condition consists of “excessive” sexual behaviors and disorders accompanied by personal distress and social and medical morbidity. Hypersexual disorder is conceptualized as primarily a non-paraphilic sexual desire disorder with impulsivity. Pathophysiological perspectives include dysregulation of sexual arousal and desire, sexual impulsivity, sexual addiction, and sexual compulsivity. The nucleus accumbens, situated within the ventral striatum, mediates the reinforcing effects of drugs of abuse, such as cocaine, alcohol, nicotine, and food as well as music. Indeed, it is believed that this structure mandates behaviors elicited by incentive stimuli. These behaviors include natural rewards like feeding, drinking, sexual behavior, and exploratory locomotion. An essential rule of positive reinforcement is that motor responses will increase in magnitude and vigor if followed by a rewarding event. Here, we are hypothesizing that there is a common mechanism of action (MOA) for the powerful effects drugs, music, food, and sex have on human motivation. The human drive for the three necessary motivational behaviors “hunger, thirst, and sex” may all have common molecular genetic antecedents that, if impaired, lead to aberrant behaviors. We hypothesize that based on a plethora of scientific support hypersexual activity is indeed like drugs, food, and music that activate brain mesolimbic reward circuitry. Moreover, dopaminergic gene and possibly other candidate neurotransmitter-related gene polymorphisms affect both hedonic and anhedonic behavioral outcomes. There is little known about both the genetics and epigenetics of hypersexuality in the current literature. However, we anticipate that future studies based on assessments with clinical instruments combined with genotyping of sex addicts will provide evidence for specific clustering of sexual typologies with polymorphic associations. The authors are also encouraging both clinical and academic scientists to embark on research using neuroimaging tools to examine natural dopaminergic agonistic agents targeting specific gene polymorphisms to “normalize” hyper- or hyposexual response.

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Section: Reviewmentioning

confidence: 99%

Hypersexuality Addiction and Withdrawal: Phenomenology, Neurogenetics and Epigenetics.

Blum¹,

Badgaiyan²,

Gold³

2015

Cureus

View full text Add to dashboard Cite

show abstract

“…Moreover, though initially conceptualized as resulting from peer imitation of child-onset or life-course-persistent youth, there is mounting evidence from twin studies that adolescent-onset or adolescent-limited antisocial behavior may also be genetically influenced. Burt and Mikolajewski not only confirmed these findings with the DATl gene but extended these findings to include the His452Tyr variant of the gene encoding the 5-HT2A receptor as well [ 62 ], More recently, Jozkow et al reported an association between the sexual dimension of aging males' symptoms (AMS) and genetic variants of 5-HTRlB G861C [ 63 ]. Moreover, Sales, et al found through multivariable logistic regression analysis, an interaction between abuse and the 5-HTTLPR group whereby there was a significant association with non-change status, along with partner communication frequency scores at follow-up [ 64 ] Having a history of abuse was significantly associated with greater odds of non-change in condom use post-intervention for only those with the s allele.…”

Section: Reviewmentioning

confidence: 90%

Hypersexuality Addiction and Withdrawal: Phenomenology, Neurogenetics and Epigenetics

Blum¹,

Badgaiyan²,

Gold³

2015

Cureus

View full text Add to dashboard Cite

Hypersexuality has been defined as abnormally increased sexual activity. Epidemiological and clinical studies have shown that this non-paraphilic condition consists of "excessive" sexual behaviors and disorders accompanied by personal distress and social and medical morbidity. It is a very controversial and political topic in terms of how best to categorize it as similar or not similar to addictive behaviors including substance abuse. Hypersexual disorder is conceptualized as a non-paraphilic sexual desire disorder with impulsivity. Pathophysiological perspectives include dysregulation of sexual arousal and desire, sexual impulsivity, and sexual compulsivity. The nucleus accumbens, situated within the ventral striatum, mediates the reinforcing effects of drugs of abuse, such as cocaine, alcohol, nicotine, and food as well as music. Indeed, it is believed that this structure mandates behaviors elicited by incentive stimuli. These behaviors include natural rewards like feeding, drinking, sexual behavior, and exploratory locomotion. An essential rule of positive reinforcement is that motor responses will increase in magnitude and vigor if followed by a rewarding event. Here, we are hypothesizing that there is a common mechanism of action (MOA) for the powerful effects drugs, music, food, and sex have on human motivation. The human drive for the three necessary motivational behaviors "hunger, thirst, and sex" may all have common molecular genetic antecedents that, if impaired, lead to aberrant behaviors. We hypothesize that based on a plethora of scientific support hypersexual activity is indeed like drugs, food, and music that activate brain mesolimbic reward circuitry. Moreover, dopaminergic gene and possibly other candidate neurotransmitter-related gene polymorphisms affect both hedonic and anhedonic behavioral outcomes. There is little known about both the genetics and epigenetics of hypersexuality in the current literature. However, we anticipate that future studies based on assessments with clinical instruments combined with genotyping of sex addicts will provide evidence for specific clustering of sexual typologies with polymorphic associations. There have been some studies using electrophysiological techniques that do not support the view that hypersexuality is indeed similar to substance abuse and other behavioral addictions. The authors are also encouraging both clinical and academic scientists to embark on research using neuroimaging tools to examine natural dopaminergic agonistic agents targeting specific gene polymorphisms to "normalize" hypersexual behavior.

show abstract

Polymorphic Variants of Neurotransmitter Receptor Genes May Affect Sexual Function in Aging Males: Data from the HALS Study

Cited by 2 publications

References 30 publications

Hypersexuality Addiction and Withdrawal: Phenomenology, Neurogenetics and Epigenetics.

Hypersexuality Addiction and Withdrawal: Phenomenology, Neurogenetics and Epigenetics.

Hypersexuality Addiction and Withdrawal: Phenomenology, Neurogenetics and Epigenetics

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