Polymorphic variants of the immune response genes as risk factors for primary progressive multiple sclerosis

Popova, E. V.; Kiselev, Ivan; Boyko, A. N.; Сиверцева, С А; Malkova, N A; Korobko, D. S.; Спирин, Н Н; Kasatkin, D. S.; Karaeva, A V; Turova, E L; Spirina, N N; Volkova, L. I.; Baulina, Natalia; Bashinskaya, Vitalina; Кулакова, О. Г.; Фаворова, О. О.

doi:10.17116/jnevro20171172214-21

Cited by 4 publications

(2 citation statements)

References 41 publications

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“…Генетическая предрасположенность к инициации и прогрессированию иммунного ответа организма больного в значительной степени модулируется широким спектром факторов, включая перенесенные инфекционные и воспалительные заболевания, экологические особенности места проживания, характер пищевого рациона и пр. [6][7][8][9].…”

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“…Подобная связь также была установлена для перенесенной инфекции herpes zoster [6]. Несмотря на то что не все исследования оказались способны подтвердить предположение о наличии связи между перенесенной цитомегаловирусной инфекцией и повышением риска развития РС, вопрос о ее существовании широко обсуждается [3,8]. Особенностью результатов нашего исследования явилось достоверное преобладание перенесенных ветряной оспы и краснухи, но не цитомегаловирусной инфекции в наблюдавшейся когорте больных РС.…”

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Analytical epidemiology of multiple sclerosis in the Republic of Kabardino-Balkaria

Тлапшокова

Zikhova

2021

RJTAO

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Multiple sclerosis (MS) is a common autoimmune disease, which etiology includes a complex of genetic and environmental factors. Data suggests that their interaction can influence the age of the clinical manifestations and the course of the disease. Therefore, the study of risk factors of MS in regions with different ethnic compositions of the population and climatic and geographical characteristics is of considerable interest.Objective: to study MS risk factors prevalence in the Republic of Kabardino-Balkaria (RKB).Patients and methods. This case-control study of the representation of risk factors included a cohort of 112 MS patients living in two regions of the RKB (Nalchik and the Prokhladnensky district). The MS diagnosis was established with the McDonald criteria (2017). MS risk factors were assessed with a unified questionnaire. 112 respondents (matched by the main demographic characteristics and place of residence) were included in the control group.Results and discussion. MS patients from the Prokhladnensky district were significantly more likely to contact harmful chemical compounds, had higher consumption of smoked meat products; and suffered from viral infections more often (all differences were significant, p<0.05). More patients with MS, regardless of their place of residence, had a history of scarlet fever than the controls (n=23; 19.5% and n=14; 13.4%, ratio indicator 0.43 (95% CI 0.32–1.01), p=0.041), and the maximum significance of this factor was found in patients who suffered from scarlet fever after the age of 15 years (n=7; 6.3% and n=1; 0.9%, ratio indicator 2.45 (95% CI 1.92–3.21), p=0.041). More patients with MS had a history of chickenpox (n=70; 62.5% and n=55; 41.1%; ratio indicator 0.78 (95% CI 0.65–0.94, p=0.032), the frequency of this factor was most significant in early (up to 7 years) disease onset. Regardless of the place of residence, patients with MS were more likely to suffer from tonsillitis and sinusitis in childhood (p=0.032).Conclusion. In the RKB, as in other regions of the Russian Federation, the risk of MS, along with a genetic predisposition, is primarily determined by environmental factors, such as contact with potentially harmful chemicals, history of somatic diseases, characteristics of the ecological situation, etc. Therefore, MS risk is higher in people exposed to these factors before the age of 7 years and does not depend on the place of residence.

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Analytical epidemiology of multiple sclerosis in the Republic of Kabardino-Balkaria

Тлапшокова

Zikhova

2021

RJTAO

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Meta-analysis of the Selected Genetic Variants in Immune-Related Genes and Multiple Sclerosis Risk

Zhou,

Hu,

Tang

et al. 2024

Mol Neurobiol

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Radiologically isolated syndrome as a possible preclinical stage of primary-progressive multiple sclerosis

Popova

Bryukhov

Boyko

et al. 2018

Z. nevrol. psikhiatr. im. S.S. Korsakova

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The article presents a clinical case-report of transformation of radiologically isolated syndrome (RIS) to primary-progressive multiple sclerosis (PPMS). It also provides a review of international and Russian data on the comparison of clinical and MRI characteristics of PPMS with relapsing-remitting multiple sclerosis and secondary-progressive multiple sclerosis and the review of the current data on the risks of transition of RIS to PPMS.

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Polymorphic variants of the immune response genes as risk factors for primary progressive multiple sclerosis

Abstract: The genotypes of IL-4 (rs2243250)C/C and CLEC16A (rs6498169)G/G were associated with PPMS in Russians. The association between the HLA-DRB1*15 and PPMS found out in other populations was confirmed in Russians.

Cited by 4 publications

References 41 publications

Analytical epidemiology of multiple sclerosis in the Republic of Kabardino-Balkaria

Analytical epidemiology of multiple sclerosis in the Republic of Kabardino-Balkaria

Meta-analysis of the Selected Genetic Variants in Immune-Related Genes and Multiple Sclerosis Risk

Radiologically isolated syndrome as a possible preclinical stage of primary-progressive multiple sclerosis

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Polymorphic variants of the immune response genes as risk factors for primary progressive multiple sclerosis

Abstract: The genotypes of IL-4 (rs2243250)*C/C and CLEC16A (rs6498169)*G/G were associated with PPMS in Russians. The association between the HLA-DRB1*15 and PPMS found out in other populations was confirmed in Russians.

Cited by 4 publications

References 41 publications

Analytical epidemiology of multiple sclerosis in the Republic of Kabardino-Balkaria

Analytical epidemiology of multiple sclerosis in the Republic of Kabardino-Balkaria

Meta-analysis of the Selected Genetic Variants in Immune-Related Genes and Multiple Sclerosis Risk

Radiologically isolated syndrome as a possible preclinical stage of primary-progressive multiple sclerosis

Contact Info

Product

Resources

About

Abstract: The genotypes of IL-4 (rs2243250)C/C and CLEC16A (rs6498169)G/G were associated with PPMS in Russians. The association between the HLA-DRB1*15 and PPMS found out in other populations was confirmed in Russians.