Polymorphism at the <scp>TNF</scp>‐alpha gene interacts with <scp>M</scp>editerranean diet to influence triglyceride metabolism and inflammation status in metabolic syndrome patients: <scp>F</scp>rom the CORDIOPREV clinical trial

Gómez-Delgado, Francisco; Alcalá‐Díaz, Juan F.; García‐Rios, Antonio; Delgado‐Lista, Javier; Ortiz-Morales, Ana M; Rangel‐Zúñiga, Oriol A.; Tinahones, Francisco J.; González-Guardia, Lorena; Malagón, Marı́a M.; Bellido-Muñoz, E.; Ordovas, José M.; Pérez‐Jiménez, Francisco; López‐Miranda, José; Pérez-Martínez, Pablo

doi:10.1002/mnfr.201300723

Cited by 41 publications

(24 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gomez-Delgado et al reported that decreases in plasma triglyceride due to adopting a Mediterranean diet were significantly greater in 203 GG homozygotes of the tumor necrosis factor alpha gene (TNFA, rs1800629) than in 48 carriers of the A-allele, i.e. approximately 0.31 vs. 0.12 mmol/L, respectively (P = 0.005) 64 . However, plasma triglyceride concentrations averaged approximately 1.80 mmol/L at baseline and 1.52 mmol/L on the diet, and correspondingly, the differences between the GG and GA/AA genotypes were 0.38 vs. 0.19 mmol/L, respectively.…”

Section: Smokingmentioning

confidence: 99%

Gene-environment interactions due to quantile-specific heritability of triglyceride and VLDL concentrations

Williams

2020

Sci Rep

View full text Add to dashboard Cite

Gene-environment interactions due to quantile-specific heritability of triglyceride and VLDL concentrations paul t. Williams "Quantile-dependent expressivity" is a dependence of genetic effects on whether the phenotype (e.g., triglycerides) is high or low relative to its distribution in the population. Quantile-specific offspringparent regression slopes (β op) were estimated by quantile regression for 6227 offspring-parent pairs. Quantile-specific heritability (h 2), estimated by 2β op /(1 + r spouse), decreased 0.0047 ± 0.0007 (P = 2.9 × 10 −14) for each one-percent decrement in fasting triglyceride concentrations, i.e., h 2 ± Se were: 0.428 ± 0.059, 0.230 ± 0.030, 0.111 ± 0.015, 0.050 ± 0.016, and 0.033 ± 0.010 at the 90th, 75th, 50th, 25th, and 10th percentiles of the triglyceride distribution, respectively. Consistent with quantile-dependent expressivity, 11 drug studies report smaller genotype differences at lower (posttreatment) than higher (pre-treatment) triglyceride concentrations. This meant genotype-specific triglyceride changes could not move in parallel when triglycerides were decreased pharmacologically, so that subtracting pre-treatment from post-treatment triglyceride levels necessarily created a greater triglyceride decrease for the genotype with a higher pre-treatment value (purported precision-medicine genetic markers). In addition, sixty-five purported gene-environment interactions were found to be potentially attributable to triglyceride's quantile-dependent expressivity, including gene-adiposity

show abstract

Section: Smokingmentioning

confidence: 99%

Gene-environment interactions due to quantile-specific heritability of triglyceride and VLDL concentrations

Williams

2020

Sci Rep

View full text Add to dashboard Cite

show abstract

“…15 In this research, we genotyped three APOE SNPs (rs439401, rs440446 and rs7412) previously reported in the literature linked with lipid metabolism and CVD. 15 In this research, we genotyped three APOE SNPs (rs439401, rs440446 and rs7412) previously reported in the literature linked with lipid metabolism and CVD.…”

Section: Laboratory Testsmentioning

confidence: 99%

“…Biochemical measurements, deoxyribonucleic acid (DNA) isolation and genotyping have been previously described. 15 In this research, we genotyped three APOE SNPs (rs439401, rs440446 and rs7412) previously reported in the literature linked with lipid metabolism and CVD. 16,17…”

Section: Laboratory Testsmentioning

confidence: 99%

Apolipoprotein E genetic variants interact with Mediterranean diet to modulate postprandial hypertriglyceridemia in coronary heart disease patients: CORDIOPREV study

Gómez-Delgado

Alcalá‐Díaz

León-Acuña

et al. 2019

Eur J Clin Investigation

Self Cite

View full text Add to dashboard Cite

Background: We try to explore whether long-term consumption of two healthy dietary patterns (low-fat [LF] diet or Mediterranean diet [MedDiet]) interacts with the apolipoprotein E (APOE) single-nucleotide polymorphisms (SNPs: rs439401, rs440446 and rs7412) modulating postprandial hypertriglyceridemia (ppHTG) in coronary heart disease (CHD) patients. Methods and results: We selected patients from the CORDIOPREV study with genotyping and who underwent an oral fat load test (FLT) at baseline and after 3 years follow-up (n = 506). After 3 years of follow-up, we found a gene-diet interaction between the APOE rs439401 SNP and MedDiet. Specifically, T-allele carriers in the MedDiet group showed a more significant decrease in postprandial triglycerides (TG: P = 0.03) and large triacylglycerol-rich lipoproteins (TRLs) TG (large TRLs TG; P = 0.01) compared with CC subjects. Consistently, the area under the curve of TG (AUC-TG; P-interaction = 0.03) and AUC-large TRLs TG (P-interaction = 0.02)were significantly lower in T-allele carriers compared with CC subjects.

show abstract

“…There are very few dietary intervention trials with MedDiet analyzing gene-diet interactions on cardiovascular phenotypes. We have summarized the current evidence of reported interactions in Table 3 [ 63 , 64 , 75 , 76 , 77 , 78 ]. Moreover, only the PREDIMED study has analyzed gene-diet interactions from intervention with MedDiet in determining hard cardiovascular end points (total CVD incidence, stroke, myocardial infarction, CVD mortality, etc.).…”

Section: Omic Biomarkers In the Predimed Study And In Other Studiementioning

confidence: 99%

Advances in Integrating Traditional and Omic Biomarkers When Analyzing the Effects of the Mediterranean Diet Intervention in Cardiovascular Prevention

Fitó

Melander

Martínéz

et al. 2016

IJMS

View full text Add to dashboard Cite

Intervention with Mediterranean diet (MedDiet) has provided a high level of evidence in primary prevention of cardiovascular events. Besides enhancing protection from classical risk factors, an improvement has also been described in a number of non-classical ones. Benefits have been reported on biomarkers of oxidation, inflammation, cellular adhesion, adipokine production, and pro-thrombotic state. Although the benefits of the MedDiet have been attributed to its richness in antioxidants, the mechanisms by which it exercises its beneficial effects are not well known. It is thought that the integration of omics including genomics, transcriptomics, epigenomics, and metabolomics, into studies analyzing nutrition and cardiovascular diseases will provide new clues regarding these mechanisms. However, omics integration is still in its infancy. Currently, some single-omics analyses have provided valuable data, mostly in the field of genomics. Thus, several gene-diet interactions in determining both intermediate (plasma lipids, etc.) and final cardiovascular phenotypes (stroke, myocardial infarction, etc.) have been reported. However, few studies have analyzed changes in gene expression and, moreover very few have focused on epigenomic or metabolomic biomarkers related to the MedDiet. Nevertheless, these preliminary results can help to better understand the inter-individual differences in cardiovascular risk and dietary response for further applications in personalized nutrition.

show abstract

Polymorphism at the TNF‐alpha gene interacts with Mediterranean diet to influence triglyceride metabolism and inflammation status in metabolic syndrome patients: From the CORDIOPREV clinical trial

Abstract: These results suggest that the rs1800629 at the tumor necrosis factor alpha gene interacts with MedDiet to influence TG metabolism and inflammation status in MetS subjects. Understanding the role of gene-diet interactions may be the best strategy for personalized treatment of MetS.

Cited by 41 publications

References 49 publications

Gene-environment interactions due to quantile-specific heritability of triglyceride and VLDL concentrations

Gene-environment interactions due to quantile-specific heritability of triglyceride and VLDL concentrations

Apolipoprotein E genetic variants interact with Mediterranean diet to modulate postprandial hypertriglyceridemia in coronary heart disease patients: CORDIOPREV study

Advances in Integrating Traditional and Omic Biomarkers When Analyzing the Effects of the Mediterranean Diet Intervention in Cardiovascular Prevention

Contact Info

Product

Resources

About