Polymorphism in ficolin-1 (FCN1) gene is associated with an earlier onset of type 1 diabetes mellitus in children and adolescents from northeast Brazil

Abstract

Ficolins are innate immune proteins able to activate the complement system by the lectin pathway. Single nucleotide polymorphisms (SNPs) of FCN1 and FCN2 genes, encoding for ficolin 1 and 2, have been related to the susceptibility to infectious and autoimmune disease. This study aims at investigating the association of SNPs at FCN1 and FCN2 gene with the development of type 1 diabetes mellitus (T1D). Two SNPs at FCN1: rs2989727 and rs1071583 and three at FCN2: rs17514136, rs3124954 and rs7851696 were studied in 204 children diagnosed with T1D and 193 healthy individuals. No direct associations were found with the T1D onset or with the insurgence of T1D related celiac disease (CD) and autoimmune thyroiditis (AIDT). However, the genotype T/T (rs1071583) of FCN1 was associated with an early age at T1D diagnosis compared with C/C or C/T genotypes (p= 0.05), around two years of difference. Thus, our results suggest that the T/T genotype (rs1071583) is not directly involved in the initial steps of T1D onset, but, after the trigger that induces T1D, individual carrying this genotype could increase/accelerate the pancreatic autoimmune response

Genome wide DNA differential methylation regions in colorectal cancer patients in relation to blood related family members, obese and non-obese controls - a preliminary report

“…HK3, FCN1, CAMK1, GLUT1/SLC2A1 and GLUT3/SLC2A3 are involved in glucose and insulin metabolism that played vital role in development of obesity and diabetes. FCN1 gene is associated with an earlier onset of type 1 diabetes mellitus in children and adolescents [ 31 ]. PEMT, ALDH1L1, DNMT3A are critical genes in the methylation pathways.…”

“…SEPT9 gene was reported as being a promising biomarker for early detection and screening of CRC [ 29 , 30 ], which is also presented in our results using the blood samples. CAMK1, GLUT1/SLC2A1 and GLUT3/SLC2A3 genes were involved in glucose and insulin metabolism that played vital role in development of obesity and diabetes [ 31 ].…”

Pattern Recognition Molecules of Lectin Complement Pathway in Ischemic Stroke

“… 36 Moreover, there is no association between this SNP and diseases such as systemic lupus erythematosus, type 1 diabetes mellitus, celiac disease and autoimmune thyroiditis. 66 , 67 It was revealed also that rs2989727 do not affect the expression of FCN1 in monocytes. 37 …”

Bioinformatics Analysis of Key Genes and Pathways for Obesity Associated Type 2 Diabetes Mellitus as a Therapeutic Target

“…GRK2 [151], ADCY3 [152], FASN (fatty acid synthase) [153], DGKD (diacylglycerol kinase delta) [154], DGKQ (diacylglycerol kinase theta) [154], IP6K1 [155], ANXA1 [156], SUCNR1 [157], PRNP (prion protein) [158], CXCR4 [159], CAV1 [160], LCN2 [161], AQP9 [162], NMU (neuromedin U) [163], NPY1R [164], FFAR2 [165], OSM (oncostatin M) [166] and TREM1 [167] were reported in obesity associated type 2 diabetes mellitus. UNC13B [168], PFKFB3 [169], FCN1 [170] and SLC11A1 [171] were involved in progression of type 1 diabetes, but these genes might be liable for progression of obesity associated type 2 diabetes mellitus.…”

“…PLD2 [117], FLNA (filamin A) [ [164], FFAR2 [165], OSM (oncostatin M) [166] and TREM1 [167] were reported in obesity associated type 2 diabetes mellitus. UNC13B [168], PFKFB3 [169], FCN1 [170] and SLC11A1 [171] were involved in progression of type 1 diabetes, but these genes might be liable for progression of obesity associated type 2 diabetes mellitus.…”