Polymorphism in interleukin-7 receptor α gene is associated with faster CD4+ T-cell recovery after initiation of combination antiretroviral therapy

Abstract

T-allele homozygosity in rs6897932 is a predictor for faster CD4⁺ T-cell recovery after initiation of cART in HIV-infected whites, however, only in the first phase of immune recovery.

IL7RApolymorphisms are not associated with AIDS progression

“…Apparently, our results of IL7RA polymorphisms appear to be discordant with previous studies, as these IL7RA SNPs have been previously related to AIDS progression in na€ ıve patients and CD4+ T-cell recovery in patients on cART [8][9][10]12,17]. However, we found IL7RA polymorphisms (rs6897932, rs987106 and rs10491434) were not associated with rapid AIDS progression in two Spanish large cohorts (CoRIS and LTNPs cohorts).…”

“…We selected three IL7RA polymorphisms located at three regulatory regions [rs6897932 (exon 6), rs987106 (intronic region) and rs10491434 (3 0 UTR)], which have been recently related to AIDS progression in ART-na€ ıve patients and CD4+ T-cell recovery in patients on cART [8][9][10]12,17].…”

IL7RA polymorphisms predict the CD4+ recovery in HIV patients on cART

“…By contrast, rs6897932 TT genotype is related to lower plasma levels of soluble CD127 (sCD127) . In a recent article, rs6897932 T allele has been related to faster CD4+ T‐cell recovery in European whites HIV‐infected patients on cART . However, in that paper, Hartling et al .…”

Incomplete immune reconstitution in HIV/AIDS patients on antiretroviral therapy: Challenges of immunological non-responders

“…The CCL3L1‐CCR5 genotypes, polymorphisms in CD14 and TLR4, mitochondrial haplogroup H, and IL18 G variant allele and genotype were associated with enhanced long‐term CD4 + T‐cell recovery in HIV‐1‐infected patients on suppressive ART. The IL‐7 receptor subunit alpha (IL7RA) rs6897932 CT/TT genotype was related to a faster and better CD4 + T‐cells recovery compared to that of the CC genotype; a potential mechanism is that signal transduction and proliferation in response to IL‐7 was is substantially higher in the "TT" genotype compared to that in the "CC" genotype in HIV‐infected individuals . A study by Greenblatt et al.…”