Polymorphism in stratum corneum lipids

Ongpipattanakul, Boonsri; Francoeur, Michael L.; Potts, Russell O.

doi:10.1016/0005-2736(94)90040-x

Cited by 125 publications

(75 citation statements)

References 30 publications

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“…Comparisons of stratum corneum extracted lipids with dmpc and dmpc-cholesterol bilayer systems have suggested that liquid crystalline phase dmpc-cholesterol bilayers would be a reasonable model of stratum corneum lipids for diffusion coefficients of solute molecules 22,24,31 and is further corroborated by the agreement for the calculated and experimental fentanyl flux. However, the effects of permeation enhancers on dmpc/cholesterol bilayer systems might be different from their effects on stratum corneum lipids, and experimental verification of the degree to which oleic acid increases fentanyl flux is needed.…”

Section: Discussionmentioning

confidence: 67%

Multiscale Modeling Framework of Transdermal Drug Delivery

2009

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Abstract-This study addresses the modeling of transdermal diffusion of drugs to better understand the permeation of molecules through the skin, especially the stratum corneum, which forms the main permeation barrier to percutaneous permeation. In order to ensure reproducibility and predictability of drug permeation through the skin and into the body, a quantitative understanding of the permeation barrier properties of the stratum corneum (SC) is crucial. We propose a multiscale framework of modeling the multicomponent transdermal diffusion of molecules. The problem is divided into subproblems of increasing length scale: microscopic, mesoscopic, and macroscopic. First, the microscopic diffusion coefficient in the lipid bilayers of the SC is found through molecular dynamics (MD) simulations. Then, a homogenization procedure is performed over a model unit cell of the heterogeneous SC, resulting in effective diffusion parameters. These effective parameters are the macroscopic diffusion coefficients for the homogeneous medium that is ''equivalent'' to the heterogeneous SC, and thus can be used in finite element simulations of the macroscopic diffusion process. The resulting drug flux through the skin shows very reasonable agreement to experimental data.

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Section: Discussionmentioning

confidence: 67%

Multiscale Modeling Framework of Transdermal Drug Delivery

2009

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“…These characteristics contribute to the suitability of FT-IR as a useful technique for studying stratum corneum lipid structure (Ongpipattanakul et al 1994). FTIR spectra of lipid bilayers show typical absorption patterns in the 3000-2800 cm −1 region that are related to C-H 2 stretching (Parker 1983).…”

Section: Discussionmentioning

confidence: 99%

Comparative studies on the effects of water, ethanol and water/ethanol mixtures on chemical partitioning into porcine stratum corneum and silastic membrane

Merwe

Riviere

2005

Toxicology in Vitro

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The effects of water and ethanol vehicles on stratum corneum and silastic membrane partitioning of 11 industrial and agricultural compounds were studied to aid in characterizing and assessing risk from skin exposure. Zero percent, 50% and 100% aqueous ethanol solutions were used as solvents for 14 C labeled phenol, 4-nitrophenol, pentachlorophenol, dimethyl parathion, parathion, chloropyrifos, fenthion, triazine, atrazine, simazine and propazine. Compound partitioning between the solvents and porcine stratum corneum/silastic membrane were estimated. Stratum corneum was exposed to aqueous ethanol ranging from 0% to 100% v/v ethanol in 20% increments and Fourier transform infrared spectroscopy (FT-IR) was used to obtain an index of lipid disorder. Gravimetry and FT-IR were used to demonstrate lipid extraction in aqueous ethanol solutions.Partitioning patterns in silastic membranes resembled those in stratum corneum and were correlated with octanol/water partitioning. Partitioning was highest in water and was higher from 50% ethanol than from 100% ethanol, except for parathion, 4-nitrophenol, atrazine and propazine. Correlation existed between molecular weight and partitioning in water, but not in ethanol and ethanol/water mixtures. Lipid order, as reflected in FT-IR spectra, was not altered. These studies suggest that stratum corneum partitioning of the compounds tested is primarily determined by relative compound solubility between the stratum corneum lipids and the donor solvent. Linear relationships existed between octanol/water partitioning and stratum corneum partitioning.Partitioning was also correlated with molecular weight in water solvent systems, but not in ethanol and ethanol/water mixtures. Ethanol and ethanol/water mixtures altered the stratum corneum through lipid extraction, rather than through disruption of lipid order.

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“…3 . Within the lipid lamellae, the lipids have a dense (orthorhombic) lateral organization, although a subpopulation of the lipids can be less densely packed in a hexagonal organization (30)(31)(32).…”

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confidence: 99%